Results 51 to 60 of about 44,670 (249)

Generative and Experimental Validation of High Refractive Index Polymers via Domain Knowledge Approach with Small Data

Advanced Intelligent Discovery, EarlyView.
This research demonstrates that the combination of domain knowledge–based multiple regression, multi‐objective Bayesian optimization, and generative models is a suitable prediction tool for candidates of high refractive index polymers, even with the constraints in the model trained on limited data. The experimental validation can reproduce the proposed
Takuya Yokoo, Seigo Watanabe, Hana Matsunaga, Kenichi Oyaizu   +3 more
wiley   +1 more source

Pyridine C─N Transposition via Cycloaddition–Cycloreversion

Angewandte Chemie, EarlyView.
Transposition of pyridine nitrogen from the 4‐ to the 3‐position is described using two open and shut sequences: a nucleophile addition ring‐open ring‐closure, followed by a nitrile Diels–Alder cycloaddition cycloreversion. The nitrogen swap is particularly effective for tertiary alkyl substituents, transforming easily accessible para‐alkylated ...
Aífe Conboy, Michael F. Greaney
wiley   +2 more sources

Synthesis and structure of salts of 2-(((3-mercapto-5-methyl-4H-1,2,4-triazole-4-yl)imino)methyl)benzoic acid

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
Modern pharmacy and medicine can offer a substantial number of highly effective synthetic medicines. A great portion of these medicines falls into the group of 1,2,4-triazole derivatives.
T. V. Hlazunova
doaj   +1 more source

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

Synthesis of Some Heterocyclic Compounds derived from 2-mercapto pyrimidine

مجلة بغداد للعلوم, 2010
In this work 2-hydrazino pyrimidine (1) was prepared from 2-mercapto pyrimidine with hydrazine hydrate. Treatment of (1) with active methylene compounds gave 2-(3,5-dimethyl -1 H – Pyrazole-1-yl) pyrimidine , whereas the reaction of (1) with ...
Baghdad Science Journal
doaj   +1 more source

Precision Switching and Coupled Motion in a [3]Rotaxane Molecular Machine

Angewandte Chemie, EarlyView.
A [3]rotaxane, composed by two crown ether macrocycles and an axle presenting three recognition sites, is operated through both chemical and electrochemical stimuli. The position of the macrocycles is precisely controlled by sequential stimulation and the processes are fully reversible. The characterization of the system revealed the macrocycles affect
Leonardo Andreoni, Jessica Groppi, Alberto Credi, Serena Silvi   +3 more
wiley   +2 more sources

Experimental and DFT Investigation on the Corrosion Inhibition of Mild Steel by 1, 2, 3- triazole Regioisomers in 1M hydrochloric Acid Solution

International Journal of Electrochemical Science, 2019
The inhibition effect of new isomers of the triazole derivative family, namely 1-[(4-ethyl-2-phenyl-4, 5- dihydro-1, 3-oxazol-4-yl)methyl]-4-phenyl-1H-1, 2, 3-triazole (Ph4) and 1-[(4-ethyl-2-phenyl-4, 5- dihydro-1, 3-oxazol-4-yl)methyl]-5-phenyl-1H-1, 2,
H. Rahmani, K. Ismaily Alaoui, K.M. Emran, A. El Hallaoui, M. Taleb, S. El Hajji, B. Labriti, E. Ech-chihbi, B. Hammouti, F. El-Hajjaji   +9 more
doaj   +1 more source

Auf dem Weg zu chromoselektiven Transformationen in biologischen Systemen: Perspektiven und Herausforderungen

Angewandte Chemie, EarlyView.
Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley   +1 more source

Phosphoryl Radicals from Trivalent Iminyl Phosphines: A Photocatalytic Approach to N‐Phosphoryl Azetidines

Angewandte Chemie, EarlyView.
Photochemically generated phosphoryl radicals from iminyl phosphines enable strain‐release addition to azabicyclobutanes, providing access to elusive N‐phosphoryl azetidines. Combined experimental, computational, and EPR studies reveal an unconventional water‐assisted photoredox pathway.
Chandu G. Krishnan, Gabriel Cormier, Stefano A. Serapian, Marco Bortolus, Luca Dell'Amico   +4 more
wiley   +2 more sources

The anti-HIV, anti-tumor activity of allyl derivatives of 1,2,4-triazole-5-thione, 1,3,4-thiadiazol-2-ylamine and derivatives of bicyclic systems: 1,2,4-triazole[3,4-b]1,3-thiazine, 1,2,4-triazole[3,2-b]1,3-thiazine, thiazolo[2,3-c][1,2,4]triazole

Current Issues in Pharmacy and Medical Sciences, 2012
The isomerization of 5H-3,7-diphenyl 6,7-dihydro-1,2,4-triazole[3,4-b] 1,3-thiazine (1) in a sealed tube, in the presence of aqueous Hbr, was carried out, and 7H-2,5-diphenyl-5,6-dihydro 1,2,4-triazole[3,2-b]1,3-thiazine (2) was obtained.
Leokadia Strzemecka
doaj   +1 more source