Results 31 to 40 of about 97,768,553 (154)

Human milk oligosaccharide 2'-fucosyllactose guards norovirus histo-blood group antigen co-factor binding site. [PDF]

J Virol
Histo-blood group antigens (HBGAs) are critical polymorphic glycan co-factors required for most norovirus infections (1, 2). However, human milk oligosaccharide (HMO) 2’-fucosyllactose (2’-FL), a component of human breast milk and made up of related ...
Rudd PA, Kher G, Tame JRH, Irie H, Haselhorst T, von Itzstein M, Pancera M, Hansman GS.   +7 more
europepmc   +2 more sources

Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis [PDF]

, 2019
ビフィズス菌におけるヒトへの適応進化を発見 --母乳オリゴ糖トランスポーターの獲得形質がビフィズスフローラ形成を促す--. 京都大学プレスリリース. 2019-09-05.The human gut microbiota established during infancy has persistent effects on health.
Lo Leggio, Leila, Sugiyama, Yuta, Urashima, Tadasu, Yokota, Atsushi, Kitaoka, Motomitsu, Hansen, Morten Ejby, Yachi, Hiroyuki, Sakanaka, Mikiyasu, Leggio, Leila Lo, Hirose, Junko, Yoshida, Keisuke, Fukiya, Satoru, Abou Hachem, Maher, Xiao, Jin zhong, Katoh, Toshihiko, Xiao, Jin-zhong, Odamaki, Toshitaka, Katayama, Takane, Gotoh, Aina, Kurihara, Shin   +19 more
core   +1 more source

study [PDF]

, 2023
We explored the potential for the prebiotic oligofructose and prebiotic candidate 2'fucosyllactose, alone and in combination (50:50 blend) to induce physiologically relevant increases in neurotransmitter (γ-aminobutyric acid, serotonin, tryptophan, and ...
Robert Adrian Rastall, Peter Philip James Jackson, Jackson, Peter Philip James, Rastall, Robert Adrian, Anisha Wijeyesekera, Wijeyesekera, Anisha   +5 more
core   +1 more source

2′-Fucosyllactose Ameliorates Aging-Related Osteoporosis by Restoring Gut Microbial and Innate Immune Homeostasis [PDF]

Journal of Advanced Research
Bowei Zhang, Jing-Min Liu, Yaozhong Hu
exaly   +2 more sources

Engineering Escherichia coli MG1655 for Highly Efficient Biosynthesis of 2′-Fucosyllactose by De Novo GDP-Fucose Pathway

, 2023
2′-Fucosyllactose (2′-FL), the most typical human milk oligosaccharide, is used as an additive in premium infant formula. Herein, we constructed two highly effective 2′-FL synthesis producers via a de novo GDP-fucose pathway from engineered Escherichia ...
Yihan Chen, Jiawei Meng (1935421), Yuanlin Liu (6369383), Jiawei Meng, Yingying Zhu (331728), Hao Wang, Yingying Zhu, Yuanlin Liu, Roulin Chen, Wanmeng Mu, Roulin Chen (13046521), Wanmeng Mu (408651), Yihan Chen (517320), Hao Wang (39217)   +13 more
core   +1 more source

Plasmid Display for Stabilization of Enzymes Inside the Cell to Improve Whole-Cell Biotransformation Efficiency

Frontiers in Bioengineering and Biotechnology, 2020
Recombinant whole-cell biocatalysts are widely used for biotransformation of valuable products. However, some key enzymes involved in biotransformation processes are unstable and cannot be easily expressed in the functional form.
Yunjeong Park, Jonghyeok Shin, Jinkyeong Yang, Hooyeon Kim, Younghun Jung, Hyunseok Oh, Yongjoon Kim, Jaehyeon Hwang, Myeongseo Park, Choongjin Ban, Choongjin Ban, Ki Jun Jeong, Sun-Ki Kim, Dae-Hyuk Kweon, Dae-Hyuk Kweon, Dae-Hyuk Kweon   +15 more
doaj   +1 more source

Novel α-L-Fucosidases from a Soil Metagenome for Production of Fucosylated Human Milk Oligosaccharides. [PDF]

PLoS ONE, 2016
This paper describes the discovery of novel α-L-fucosidases and evaluation of their potential to catalyse the transglycosylation reaction leading to production of fucosylated human milk oligosaccharides.
Mateusz Lezyk, Carsten Jers, Louise Kjaerulff, Charlotte H Gotfredsen, Maria D Mikkelsen, Jørn D Mikkelsen   +5 more
doaj   +1 more source

¹H NMR Metabolomics of Chinese Human Milk at Different Stages of Lactation among Secretors and Non-Secretors

Molecules, 2022
Human milk is an intricate, bioactive food promoting infant health. We studied the composition of human milk samples collected over an 8-month lactation using 1H NMR metabolomics.
Maaria Kortesniemi, Tahereh Jafari, Yumei Zhang, Baoru Yang   +3 more
doaj   +1 more source

Determination of 2′-Fucosyllactose and Lacto-N-neotetraose in Infant Formula

Molecules, 2018
Human milk oligosaccharides (HMO) are the third most abundant solid component of human milk. It is likely that they are responsible for at least some of the benefits experienced by breast-fed infants.
Sean Austin, Denis Cuany, Julien Michaud, Bernd Diehl, Begoña Casado   +4 more
doaj   +1 more source

Table_1_The Human Milk Oligosaccharide 2′-Fucosyllactose Alleviates Liver Steatosis, ER Stress and Insulin Resistance by Reducing Hepatic Diacylglycerols and Improved Gut Permeability in Obese Ldlr-/-.Leiden Mice.DOCX

, 2022
Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder that is associated with gut dysbiosis, enhanced gut permeability, adiposity and insulin resistance. Prebiotics such as human milk oligosaccharide 2′-fucosyllactose are thought
Ivana Bobeldijk-Pastorova (254317), Martin Giera (1598620), Martien Caspers (568467), Frank Schuren (126104), Robert Kleemann (47402), Eveline Gart (10323017), Joline Attema (12889172), Christa de Ruiter (12889175), Yan Qin (118276), Marianne Heer (12889178), Kanita Salic (4225822), Martine C. Morrison (10323026)   +11 more
core   +1 more source