Results 111 to 120 of about 26,508 (195)

A novel, highly sensitive and specific biomarker for Niemann-Pick type C1 disease [PDF]

, 2015
Background Lysosomal storage disorders (LSDs), are a heterogeneous group of rare disorders caused by defects in genes encoding for proteins involved in the lysosomal degradation of macromolecules. They occur at a frequency of about 1 in 5,000 live births,
Cortina-Borja, Mario, Eichler, Sabrina, Eisa, Nada Al, Giese, Anne-Katrin, Grittner, Ulrike, Kramp, Guido, Lukas, Jan, Mascher, Hermann, Platt, Frances M., Porter, Forbes D., Rolfs, Arndt, Vruchte, Danielle te   +11 more
core   +2 more sources

Smart molecular design for functional cellulose gels and flexible devices

Smart Molecules, Volume 4, Issue 1, March 2026.
This review systematically outlines the performance enhancement of cellulose gels, presenting optimization strategies across molecular, supramolecular, and macroscopic scales. It discusses advanced approaches to improve their mechanical, electrical, and thermal properties, and highlights promising applications in flexible robotics, electric devices, e ...
Zeshi Li, Minxin Wang, Geyuan Jiang, Jianhong Zhou, Donghan Li, Weihua Zhang, Dawei Zhao   +6 more
wiley   +1 more source

Fostering collaborative research for rare genetic disease: The example of Niemann-Pick type C disease [PDF]

, 2016
Rare disease represents one of the most significant issues facing the medical community and health care providers worldwide, yet the majority of these disorders never emerge from their obscurity, drawing little attention from the medical community or the
Austin, Christopher P, Davidson, Cristin D, Jacoby, Jonathan, Marella, Philip D, Ory, Daniel S, Ottinger, Elizabeth A, Porter, Forbes D, Vite, Charles H, Walkley, Steven U   +8 more
core   +2 more sources

Preparation of Aqueous Solutions with Information on Solids Using Natural Polymers by Solid‐State Mixing

The Chemical Record, Volume 26, Issue 3, March 2026.
The solid‐state information, such as chiral crystal formation, crystal polymorphism, mechanochromism, room‐temperature phosphorescence, and fluorescence detection by molecular recognition, is maintained even when the functional guest molecules are solubilized in water using natural polymers.
Keita Yamana, Riku Kawasaki, Atsushi Ikeda   +2 more
wiley   +1 more source

Sugammadex, a neuromuscular blockade reversal agent, causes neuronal apoptosis in primary cultures. [PDF]

, 2013
Sugammadex, a γ-cyclodextrin that encapsulates selectively steroidal neuromuscular blocking agents, such as rocuronium or vecuronium, has changed the face of clinical neuromuscular pharmacology.
Aguirre Rueda, Diana, Aldasoro Celaya, Martín, García, Alma, Gil Bisquert, Anna, Granell Gil, Manuel, Iradi Casal, Antonio, Mauricio Aviñó, María Dolores, Obrador, Elena, Palanca Sanfrancisco, José María, Vallés Martí, Lilián Soraya, Vila Salinas, José María   +10 more
core   +2 more sources

Region and Cell‐Selective Induction of Zbtb16/Plzf by Multiple Stressors in the Adult Murine Hypothalamus

European Journal of Neuroscience, Volume 63, Issue 6, March 2026.
Zbtb16 shows region‐ and cell‐specific expression in the PVN, localizing to CRH neurons in the mid‐PVN and to astrocytes in the caudal PVN, suggesting distinct neuroendocrine and immune‐related roles. ABSTRACT Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine system that regulates responses related to feeding ...
Mina Roueinfar, Pardis Mohammadzadeh, Luke A. Schwerdtfeger, Robert J. Handa, Stuart A. Tobet   +4 more
wiley   +1 more source

Low‐dose testosterone administration and oestrogen synthase availability in the female brain: A pilot study

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Testosterone and oestrogens play significant roles in female physiology, extending beyond reproductive functions to influence brain health, mood regulation, and behaviour. Testosterone low‐dose therapy is increasingly considered for alleviating sexual dysfunction symptoms in postmenopausal women, and has been recently investigated as therapy ...
Manon Dubol, My Jonasson, Kayo Takahashi, Johan Wikström, Yasuyoshi Watanabe, Gunnar Antoni, Mark Lubberink, Anat Biegon, Inger Sundström‐Poromaa, Erika Comasco   +9 more
wiley   +1 more source

Temperature Dependence of the Complexation Mechanism of Celecoxib and Hydroxyl-β-cyclodextrin in Aqueous Solution

Pharmaceutics, 2014
Hydroxypropyl-β-cyclodextrin (HP-β-CD) is commonly used as a complexation reagent to solubilize compounds with poor aqueous solubility to improve in vivo dosing. However, the degree of solubility enhancement was often limited by the formation of only a 1:
Po-Chiang Chiang, Yue Shi, Yong Cui
doaj   +1 more source

Preparation and characterization of artemether inclusion complexes with hydroxypropyl-β-cyclodextrin [PDF]

, 2017
Purpose: To investigate experimentally the inclusion of artemether into the cavity of  hydroxypropyl-β-cyclodextrin and examine its effect on the solubility and dissolution rate of the drug.Methods: Inclusion complexes of artemether with hydroxypropyl-β ...
Allagh, Suzane T., Bhatia, Pat G., Ofokansi, Kenneth C., Yahaya, Zwanden Sule   +3 more
core   +2 more sources

EVALUATING THE THERAPEUTIC EFFICACY OF RESTORING WILD-TYPE P53 ACTIVITY IN P53-MUTANT TUMORS [PDF]

, 2017
The p53 transcription factor is the most frequently altered in human cancers usually via missense mutations that undermine its transcriptional activity. Clinically, TP53 mutations have been shown to be remarkably predictive of refractoriness to treatment,
Larsson, Connie A
core   +1 more source