Results 81 to 90 of about 5,480 (215)

Innovative Drug Delivery Systems for the Treatment of Glaucoma

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu, Junzhi Li, Zhenlin Chen, Jinyu Zhang, Siqi Feng, Jiaying Huang, Yawen Chu, Xue Zhou, Wei Wang, Shangsi Chen   +9 more
wiley   +1 more source

Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

Drug Design, Development and Therapy, 2015
Yazeed HM Aljimaee,1 Abdel-Rahim M El-Helw,1 Osama AA Ahmed,1,2 Khalid M El-Say1,3 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and ...
Aljimaee YH, El-Helw AM, Ahmed OA, El-Say KM   +3 more
doaj  

Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae.

PLoS ONE, 2012
Zebrafish are rapidly growing in popularity as an in vivo model system for chemical genetics, drug discovery, and toxicology, and more recently also for natural product discovery. Experiments involving the pharmacological evaluation of small molecules or
Jan Maes, Lien Verlooy, Olivia E Buenafe, Peter A M de Witte, Camila V Esguerra, Alexander D Crawford   +5 more
doaj   +1 more source

Comparative Functionality and Processing of Plant‐Proteins: A Path Toward Optimized Sustainable Plant‐Based Meat Analogues (PBMAs): A Review

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
The review provides a comprehensive comparison in terms comparison of commercially established and emerging plant protein sources, focusing on their structural, rheological, and sensory attributes for developing sustainable plant‐based meat analogues (PBMAs).
Mian N. Riaz, Fariha Irshad, Muhammad Bilal Haider, Debomitra Dey   +3 more
wiley   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Development of Buccal Patches for Delivery of Darifenacin from Beta-Cyclodextrin Complexes

Revista de Ciências Farmacêuticas Básica e Aplicada, 2014
Drug-cyclodextrin complexes improve aqueous solubility and dissolution rate of poorly water-soluble drugs. Solubilisation followed by buccal delivery of poorly water-soluble drugs can be advantageous for increasing drug absorption.
Swati C. Jagdale, Prachyasuman Mohanty, Aniruddha R. Chabukswar, Bhanudas S. Kuchekar   +3 more
doaj   +2 more sources

Enhanced Solubility and Anticancer Potential of Mansonone G By β-Cyclodextrin-Based Host-Guest Complexation: A Computational and Experimental Study

Biomolecules, 2019
Mansonone G (MG), a plant-derived compound isolated from the heartwood of Mansonia gagei, possesses a potent antitumor effect on several kinds of malignancy. However, its poor solubility limits the use for practical applications. Beta-cyclodextrin (β
Panupong Mahalapbutr, Piyanuch Wonganan, Thanapon Charoenwongpaiboon, Manchumas Prousoontorn, Warinthorn Chavasiri, Thanyada Rungrotmongkol   +5 more
doaj   +1 more source

Lysosomal cholesterol accumulation sensitizes to acetaminophen hepatotoxicity by impairing mitophagy.

, 2015
The role of lysosomes in acetaminophen (APAP) hepatotoxicity is poorly understood. Here, we investigated the impact of genetic and drug-induced lysosomal cholesterol (LC) accumulation in APAP hepatotoxicity.
Alarcón-Vila, C, Baulies, A, Fernández-Checa, JC, García-Ruiz, C, Kaplowitz, N, Martínez, L, Núñez, S, Ribas, V, Suda, J, Torres, S, Ybanez, MD   +10 more
core   +1 more source

The Effect of 2-Hydroxypropyl-β-Cyclodextrin on Post-Thaw Parameters of Cryopreserved Jack and Stallion Semen [PDF]

, 2013
Cyclodextrins improve post-thaw viability and motility of semen as well as mediate cholesterol efflux and subsequent acrosome reaction in spermatozoa from several species.
Evans, Lawrence, Madison, Rebecca, Youngs, Curtis, Youngs, Curtis   +3 more
core   +3 more sources

Lateral hypothalamic melanin concentrating hormone‐expressing neurons both promote and are required for cue‐potentiated feeding

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Food‐related stimuli can promote feeding behaviors independent of metabolic need. Cue‐potentiated feeding (CPF) studies in rodents offer the potential to reveal the psychobiological mechanisms underlying learned overeating behaviors. We examined whether lateral hypothalamic area (LHA) cells expressing the feeding signal Melanin Concentrating ...
Lauren M. Raycraft, Bingxin Mo, Allison Doneth, Jenna Lee‐Tanner, Alexander W. Johnson   +4 more
wiley   +1 more source