Results 91 to 100 of about 10,212 (248)

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles

Molecules, 2003
5-Nitro-2-pyridone can be selectively N-phenacylated, and the resulting phenacylpyridones I undergo cyclization to 6-nitrooxazolo[3,2-a]pyridinium salts II.
Eugene V. Babaev, Alexander A. Bush
doaj   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Rapid changes in Atlantic grey seal milk from birth to weaning – immune factors and indicators of metabolic strain [PDF]

, 2017
True seals have the shortest lactation periods of any group of placental mammal. Most are capital breeders that undergo short, intense lactations, during which they fast while transferring substantial proportions of their body reserves to their pups ...
Bawazeer, Sami, Burchmore, Richard J.S., Kennedy, Malcolm W., Lowe, Amanda D., McGill, Suzanne, Pomeroy, Patrick, Watson, David G.   +6 more
core   +3 more sources

Synthesis of 4,6-dimethyl-3-cyano-2-pyridone catalysed by amino acids

Zaštita Materijala, 2017
In this work the synthesis of 4,6-dimethyl-3-cyano-2-pyridone catalyzed by amino acids was studied. In the first part of the work, the optimization was carried out by varying the initial concentration of glycine, the molar ratio of the reactants ...
Nevena Ž. Prlainović, Nataša Ž. Šekuljica, Jelena M. Mirković, Dušan Ž. Mijin   +3 more
doaj   +1 more source

Harnessing Molecular and Bioactivity Network Analysis to Prioritize Antibacterial Compound Isolation From Ant‐Associated Fungi

Phytochemical Analysis, Volume 36, Issue 5, Page 1351-1366, July 2025.
ABSTRACT Introduction Antimicrobial resistance is a global public health problem that requires the development of new bioactive compounds. In this context, metabolomic analyses can expedite the research of fungal metabolites as a valuable resource. Objectives To investigate the metabolic profiles and isolate antibacterial compounds from micromycetes ...
Ángel S. Aguilar‐Colorado, Jesús Morales‐Jiménez, José Rivera‐Chávez   +2 more
wiley   +1 more source

Dakin-West Trick in the Design of Novel 2-Alkyl(aralkyl) Derivatives of Oxazolo[3,2-a]pyridines

Molecules, 2005
A series of previously unavailable derivatives of 2-alkyl- and 2-benzylderivatives of oxazolo[3,2-a]pyridines III were obtained via tandem ring opening and ring closure from stable mesoionic 3-acyloxazolo[3,2-a]pyridinium-2-olates I.
Eugene V. Babaev, Alexander A. Bush, Zeinul-Gabiden M. Kazhkenov   +2 more
doaj   +1 more source

The Mechanism Exploration of Traditional Chinese Medicine's “Different Treatments for Same Disease” Concept in Osteoporosis Therapy: A Serum Metabolomics Study

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT The “different treatments for same disease” is an important concept of traditional Chinese medicine (TCM) therapy. In TCM, osteoporosis (OP) treatment is aimed at invigorating blood, strengthening spleen, and tonifying kidneys, and their typical herbs are Angelica sinensis (Oliv.) Diels (Danggui, DG), Poria cocos (Schw.) Wolf (Fuling, FL), and
Jingyuan Wen, Xuefeng Li, Zhen Wu, Liu Jiangyuan, Guanyin Wang, Xu Wang, Zhengsheng Bao, Yang Yu, Pinger Wang, Zhenyu Shi, Bing Xu, Yunhuo Cai, Hongting Jin, Jiali Chen   +13 more
wiley   +1 more source

Synthesis of 6-(2-hydroxyaryl)-2-pyridones by the reaction of chromones with cyanoacetic, acetoacetic, and malonic acid amides [PDF]

, 2013
A reaction of chromones with cyanoacetic, acetoacetic, and malonic acid amides in the presence of sodium ethoxide furnished a number of new 3-substituted 6-(2-hydroxyaryl)-2-pyridones in good yields, including those containing a polyfluoroalkyl group at ...
Anufriev, V. A., Safrygin, A. V., Sosnovskikh, V. Ya.   +2 more
core   +1 more source

Nonlocal van der Waals density functional: The simpler the better [PDF]

, 2010
We devise a nonlocal correlation energy functional that describes the entire range of dispersion interactions in a seamless fashion using only the electron density as input.
Lide D. R., Oleg A. Vydrov, Troy Van Voorhis   +2 more
core   +2 more sources