Results 61 to 70 of about 10,839 (246)

2-Bromopyridines as Versatile Synthons for Heteroarylated 2-Pyridones via Ru(II)-Mediated Domino C–O/C–N/C–C Bond Formation Reactions

Molecules
A novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)–KOPiv–Na2CO3 catalytic system.
Miha Drev, Helena Brodnik, Uroš Grošelj, Franc Perdih, Jurij Svete, Bogdan Štefane, Franc Požgan   +6 more
doaj   +1 more source

Nucleophile-Catalyzed Additions to Activated Triple Bonds. Protection of Lactams, Imides, and Nucleosides with MocVinyl and Related Groups [PDF]

, 2014
Additions of lactams, imides, (S)-4-benzyl-1,3-oxazolidin-2-one, 2-pyridone, pyrimidine-2,4-diones (AZT derivatives), or inosines to the electron-deficient triple bonds of methyl propynoate, tert-butyl propynoate, 3-butyn-2-one, N-propynoylmorpholine, or
Adler M., Aggarwal V. K., Alewi B. A., Alonso D. A., Ando K., Anna M. Costa, Ariza X., Baidya M., Balasubramaniam S., Barry C. S., Benohoud M., Bonache M.-C., Broch S., Chatterjee T., Chen H.-G., Costa A. M., Costa A. M., Dandepally S. R., David de Vicente, De Rycke N., Delamarche I., Denes F., Díez-González S., Esteban J., Faja M., Fan M.-J., Foettinger A., Goossen L. J., Goossen L. J., Gorka Etxebarría-Jardí, Hein J. E., Hosokawa T., Janey J. M., Jaume Vilarrasa, Jin S., Joan Font, Joaquim Caner, Kabir M. S., Katz E., Kurosu M., Laura Mola, Lee E., Lee E., Lewis A. F., Liao Y., Lin T. S., Liu Y., Lluís Bosch, Martín R., Matsuya Y., Mayr H., Mekkonen B., Nishimura T., Olivella A., Oriol Pineda, Peshakova L., Pursglove L. A., Ramazani A., Reisman S. E., Robinson R. S., Scheiner P., Seo J. H., Smith N. L., Spychala J., Tejedor D., Tejedor D., Trost B. M., Tyler P. C., Villa M. V. J., Wang J., Yavari I., Ylioja P. M.   +71 more
core   +2 more sources

Systemic Toxicity of L‐Mimosine in Rabbits: A Non‐Rodent Model for Safety Assessment

Journal of Applied Toxicology, Volume 46, Issue 2, Page 639-651, February 2026.
ABSTRACT L‐mimosine is a non‐protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L‐mimosine have been extensively studied in ruminants,
S. M. Ferreira, H. Zapparoli, C. S. Mussi, P. C. Maiorka, A. F. C. Andrade, S. L. Górniak, A. T. Gotardo   +6 more
wiley   +1 more source

Dichlorido[1-(1,10-phenanthrolin-2-yl)-2-pyridone]cadmium(II)

Acta Crystallographica Section E, 2008
In the title mononuclear complex, [CdCl2(C17H11N3O)], the CdII ion assumes a distorted trigonal–bipyramidal coordination geometry. The pyridone plane is twisted out of the 1,10-phenanthroline mean plane by 43.8 (3)°.
Jin-Min Li
doaj   +1 more source

Anti-Inflammatory and Proangiogenic Metabolites from the Hadal Trench-Derived Fungus Acremonium dichromosporum YP-213

Marine Drugs, 2023
Four new compounds, including two ascochlorin-type meroterpenoids acremocholrins A (1) and B (2), one pyridone alkaloid acremopyridone A (7), and one cyclopentenone derivative acremoketene A (12), together with eight known compounds (3–6 and 8–11), were ...
Yan Zhang, Jia-Bao Zhou, Shu-Ting Yang, Xin Liu, Wei Cao, Pei-Hai Li, Hao Chen, Ya-Qin Fan   +7 more
doaj   +1 more source

Asymmetric Homogeneous Hydrogenation of 2-Pyridones [PDF]

Synlett, 2015
An asymmetric homogeneous hydrogenation of 2(1H)-pyridones has been developed, using a ruthenium complex bearing two chiral N-heterocyclic carbene (NHC) ligands. To the best of our knowledge, the presented reaction is the first example of a homogeneous asymmetric conversion of 2-pyridones into the corresponding enantioenriched 2-piperidones.
Frank Glorius, Jędrzej Wysocki, Christoph Schlepphorst   +2 more
openaire   +1 more source

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]

, 2015
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum, Blackburn, Gavin, Daskalaki, Evangelia, Kalna, Gabriela, Watson, David, Zhang, Tong   +5 more
core   +2 more sources

Tosvinyl and besvinyl as protecting groups of imides, azinones, nucleosides, sultams, and lactams. Catalytic conjugate additions to tosylacetylene. [PDF]

, 2015
The use of the 2-(4-methylphenylsulfonyl)ethenyl (tosvinyl, Tsv) group for the protection of the NH group of a series of imides, azinones (including AZT), inosines, and cyclic sulfonamides has been examined.
Bosch Hereu, Lluís, Costa i Arnau, Anna M., Font, Joan, Mola Solà, Laura, Petit, Elena, Vilarrasa i Llorens, Jaume   +5 more
core   +2 more sources

Nickel‐Catalyzed cine‐Substitution Toward Carbonyl Dance

Chemistry – An Asian Journal, Volume 21, Issue 1, January 2026.
A nickel‐catalyzed cine‐substitution enables a 1,2‐carbonyl translocation (“carbonyl dance”) at tetralone derivatives under mild conditions. This transformation proceeds through enolization and selective amination, followed by hydrolysis, to afford β‐tetralones bearing migrated carbonyl groups.
Eito Moriya, Kei Muto, Junichiro Yamaguchi   +2 more
wiley   +1 more source

An overview of synthesis and biological activities of 2-pyridone derivatives over the last decade

Discover Applied Sciences
2-Pyridone frameworks are a pervasive member of the N-heterocyclic family of both chemical and therapeutic interest. 2-Pyridones and their bridged analogues have wide occurrences in nature and the presence of both aromatic and amide groups in the ...
Lopamudra Das, Tista Sengupta
doaj   +1 more source