Results 61 to 70 of about 7,997 (204)
Asymmetric Homogeneous Hydrogenation of 2-Pyridones [PDF]
Synlett, 2015 An asymmetric homogeneous hydrogenation of 2(1H)-pyridones has been developed, using a ruthenium complex bearing two chiral N-heterocyclic carbene (NHC) ligands. To the best of our knowledge, the presented reaction is the first example of a homogeneous asymmetric conversion of 2-pyridones into the corresponding enantioenriched 2-piperidones.
Frank Glorius +2 more
openaire +1 more source
Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
core +3 more sources
Targeting cancer cell mitochondria with a multivalent source of singlet oxygen
Smart Molecules, Volume 4, Issue 1, March 2026.Multivalent source of singlet oxygen can effectively target cancer cell mitochondria and cause improved cancer cell selective cytotoxicity at low micromolar concentrations. Abstract Naphthalene, anthracene and pyridone endoperoxides are known to thermally release singlet oxygen.
Wanwan Wang +4 more
wiley +1 more source
Marine Drugs, 2023 Four new compounds, including two ascochlorin-type meroterpenoids acremocholrins A (1) and B (2), one pyridone alkaloid acremopyridone A (7), and one cyclopentenone derivative acremoketene A (12), together with eight known compounds (3–6 and 8–11), were ...
Yan Zhang +7 more
doaj +1 more source
Tosvinyl and besvinyl as protecting groups of imides, azinones, nucleosides, sultams, and lactams. Catalytic conjugate additions to tosylacetylene. [PDF]
, 2015 The use of the 2-(4-methylphenylsulfonyl)ethenyl (tosvinyl, Tsv) group for the protection of the NH group of a series of imides, azinones (including AZT), inosines, and cyclic sulfonamides has been examined.
Bosch Hereu, Lluís +5 more
core +2 more sources
Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing
Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.ABSTRACT Nicotinamide is an essential precursor of NAD involved in energy metabolism. A decline in NAD levels across tissues during ageing is well‐documented, and NAD metabolism has been implicated in ovarian ageing. We investigated the relationship between ovarian ageing and the levels of nicotinamide (NAM) and its metabolite 1‐methylnicotinamide (MNA)
Cinzia Bocca +5 more
wiley +1 more source
An overview of synthesis and biological activities of 2-pyridone derivatives over the last decade
Discover Applied Sciences2-Pyridone frameworks are a pervasive member of the N-heterocyclic family of both chemical and therapeutic interest. 2-Pyridones and their bridged analogues have wide occurrences in nature and the presence of both aromatic and amide groups in the ...
Lopamudra Das, Tista Sengupta
doaj +1 more source
Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance
The FASEB Journal, Volume 40, Issue 3, 15 February 2026.Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon +6 more
wiley +1 more source
Synthesis of Some New Enaminoketones, Analogous of Milrinone, 4,Pyrones and Related 4-Pyridones [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1996 Synthesis of 4-(N,N- dimethylamino)-3-aryl-3-butene-2-one, ethyl-5-aryl-4-oxo-4H-pyran-2-carboxylate, ethyl-5-aryl-4-pyridones-2-carboxylate and 5-aryl-3-cyano-5-methyl-2-pyridones (aryl=3-thienyl, 2-furyl) are described.
Aziz Shahrisa, Salar Hemmati
doaj
catena-Poly[[(nitrato-κ2O,O′)silver(I)]-μ3-4-pyridone-κ3O:O:O]
Acta Crystallographica Section E, 2009 In the title complex, [Ag(NO3)(C5H5NO)]n, the AgI atom is coordinated by two O atoms from two different 4-pyridone ligands and two O atoms from one nitrate anion, displaying a nearly planar coordination geometry.
Xian-Ge Wu, Jun-Xia Xiao, Liang Qin
doaj +1 more source