Results 81 to 90 of about 7,997 (204)

Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study [PDF]

, 2016
Background Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal ...
Coen, M, Ibarluzea, J, Lewis, M, Maitre, L, SantaMarina, L, Sunyer, J, Toledano, MB, Villanueva, CM, Vrijheid, M   +8 more
core   +6 more sources

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 1-15, February 2026.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

Tautomeric Equilibria Studies by Mass Spectrometry [PDF]

, 2008
Tautomerism in organic chemistry has been extensively studied in condensed phase by spectrometric methods, mainly by IR and NMR techniques. Mass spectrometry studies start 40 years ago but just recently it has been recognized the importance of the mass ...
Eduardo A. Castro, Jorge J. Furlong, Mercedes M. Schiavonni, Patricia E. Allegretti   +3 more
core   +1 more source

Interplay among electrostatic, dispersion and steric interactions: Spectroscopy and quantum chemical calculations of π-hydrogen bonded complexes [PDF]

, 2017
π-hydrogen bonding interactions are ubiquitous in both materials and biology. Despite their relatively weak nature great progress has been made in their investigation by experimental and theoretical methods, but this becomes significantly more ...
Abo-Riziq, Aguado, Ahnen, Arunan, Bachorz, Becke, Biedermann, Biswal, Boughton, Boys, Braun, Brown, Buchanan, Burley, Burns, Börnsen, Carney, Chandrasekaran, Columberg, Dauster, Desiraju, Desiraju, Dessent, Dian, Duan, Dunning, Frey, Fricke, Geng, Gengeliczki, Grimme, Grimme, Gráfová, Hager, Hager, Hampel, Hill, Hill, Hill, Hill, Hill, Hohenstein, Hughes, Hättig, Jaeqx, Janda, Jeziorski, Kendall, Knizia, Korona, Kumar, Kumar, Kumar, Lee, Levitt, León, Lu, Lu, Malone, Marchetti, Matsumoto, Meyer, Mitchell, Mons, Muzangwa, Ottiger, Parker, Pfaffen, Pfaffen, Pipek, Pitoňák, Platts, Pribble, Pulay, Reid, Rodham, Saggu, Saggu, Sarkhel, Schütz, Seo, Sinnokrot, Sinnokrot, Sinnokrot, Sirianni, Steiner, Steiner, Trachsel, Tsuzuki, Tsuzuki, Turney, Tóth, Wang, Weigend, Weigend, Werner, Worth, Yousaf, Řeha, Řezáč, Řezáč, Řezáč   +101 more
core   +1 more source

Synthesis and Evaluation of Antitumor and Anti-Angiogenesis Activity of Pyrone- or Pyridone-Embedded Analogs of Cortistatin A

Marine Drugs
Simplified analogs of cortistatin A were synthesized and biologically evaluated to develop novel antitumor substances that target angiogenesis. To analyze the effect of substituents at positions corresponding to C-2 and/or C-4 of the A-ring, various ...
Yuri Fujimoto, Kanako Mizuno, Yuta Nakamura, Masayoshi Arai, Naoyuki Kotoku   +4 more
doaj   +1 more source

Synthesis of 6-(2-hydroxyaryl)-2-pyridones by the reaction of chromones with cyanoacetic, acetoacetic, and malonic acid amides [PDF]

, 2013
A reaction of chromones with cyanoacetic, acetoacetic, and malonic acid amides in the presence of sodium ethoxide furnished a number of new 3-substituted 6-(2-hydroxyaryl)-2-pyridones in good yields, including those containing a polyfluoroalkyl group at ...
Anufriev, V. A., Safrygin, A. V., Sosnovskikh, V. Ya.   +2 more
core   +1 more source

Nickel‐Catalyzed cine‐Substitution Toward Carbonyl Dance

Chemistry – An Asian Journal, Volume 21, Issue 1, January 2026.
A nickel‐catalyzed cine‐substitution enables a 1,2‐carbonyl translocation (“carbonyl dance”) at tetralone derivatives under mild conditions. This transformation proceeds through enolization and selective amination, followed by hydrolysis, to afford β‐tetralones bearing migrated carbonyl groups.
Eito Moriya, Kei Muto, Junichiro Yamaguchi   +2 more
wiley   +1 more source

Binary and ternary cocrystals of sulfa drug acetazolamide with pyridine carboxamides and cyclic amides

IUCrJ, 2016
A novel design strategy for cocrystals of a sulfonamide drug with pyridine carboxamides and cyclic amides is developed based on synthon identification as well as size and shape match of coformers.
Geetha Bolla, Ashwini Nangia
doaj   +1 more source

Reactions of 2-methylchromones with cyanoacetamides and ethyl cyanoacetate. synthesis of 6-(2-hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3- carbonitriles and 7-hydroxy-6-imino-9-methyl-6h-benzo[c]chromene-8-carbonitriles [PDF]

, 2013
Although 2-methylchromones react with cyanoacetamide and N-methyl cyanoacetamide in the presence of sodium ethoxide in refluxing ethanol to produce 6-(2-hydroxyaryl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitriles, their reactions with ethyl ...
Al Naimi, Chosh, Clarke, Eiden, Eiden, Elkaschef, Ellis, Horton, Ibrahim, Ibrahim, Ibrahim, Mahmoud, Morin, Singh, Sosnovskikh, Sosnovskikh, Sosnovskikh, Sosnovskikh, Sosnovskikh, Sosnovskikh, Sosnovskikh, Wallace, Zagorevskii, Zeid   +23 more
core   +1 more source

Synthesis of 4,6-dimethyl-3-cyano-2-pyridone catalysed by amino acids

Zaštita Materijala, 2017
In this work the synthesis of 4,6-dimethyl-3-cyano-2-pyridone catalyzed by amino acids was studied. In the first part of the work, the optimization was carried out by varying the initial concentration of glycine, the molar ratio of the reactants ...
Nevena Ž. Prlainović, Nataša Ž. Šekuljica, Jelena M. Mirković, Dušan Ž. Mijin   +3 more
doaj   +1 more source