Results 51 to 60 of about 24,429,900 (206)

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley   +2 more sources

Synthesis of New Aza-Heterocyclic Based on 2-Pyridone

Chemistry Proceedings
In this work, we present new methods of synthesis of different molecules including a 2-pyridone nucleus. First, we prepared a series of 1H-free 2-pyridones and N-alkyl 2-pyridones from ethyl cyanoacetate, aromatic aldehydes, various acetophenone ...
Ikram Baba-Ahmed, Zahira Kibou, Julio A. Seijas, Noureddine Choukchou-Braham, M. Pilar Vázquez-Tato   +4 more
doaj   +1 more source

Gold(I)‐Catalyzed Annulation of Pyridines Containing Alkyne: Synthesis of N‐Alkenyl Pyridonyl Azides via Rearrangement

Journal of Heterocyclic Chemistry, EarlyView.
One‐pot gold(I)‐catalysts synthesis was developed in order to prepare N‐alkenyl 2‐pyridonyl azides. This method provides a series of N‐alkenyl 2‐pyridonyl azides in moderate to excellent yields (up to 94%). ABSTRACT A novel strategy, involving the preparation of gold‐catalyzed cyclization salts and the rearrangement of these salts in the presence of ...
Ali Osman Karatavuk
wiley   +1 more source

O- and N-Difluoromethylation of 2-Pyridones with Chlorodifluoromethane

Журнал органічної та фармацевтичної хімії
Difluoromethylation of various 2-pyridones with the available industrial reagent chlorodifluoromethane (Freon-22) has been studied. Some relationships between the ratio of difluoromethylation products and the reaction conditions, as well as the presence ...
Kirill I. Petko, Andrey A. Filatov
doaj   +1 more source

All‐in‐One Interface Engineering From Bulk to Electrode Toward High‐Performance Micro‐Sized Silicon Anodes

Small, EarlyView.
Microsized silicon (µ‐Si, >1 µm) is one of the ideal anodes for lithium‐ion batteries. In this paper, an integrated co‐carbonization electrode (ICCE) without binder and conductive agent was prepared by precoating a uniform carbon layer on the surface of µ‐Si particles, which significantly improved the electrochemical performance.
Shuqi Wang, Lingxiao Xue, Chengzhi Zhang, Fei Wang, Zhendong Liu, Ziyi Shao, Shun Zhang, Hong‐Bin Sun, Zhenhuai Yang, Quanbing Liu, Xinwen Peng   +10 more
wiley   +1 more source

2-Pyridones from Cyanoacetamides and Enecarbonyl Compounds:  Application to the Synthesis of Nothapodytine B

, 2016
The condensation of an enone or enal with cyanoacetamide derivatives and t-BuOK furnishes either 3-cyano-2-pyridones or 3-unsubstituted-2-pyridones, depending on whether the reaction is carried out in the presence or in the absence of O2.
Kesavaram Narkunan (3028518), Denis Bouchu (2184105), Marco A. Ciufolini (117202), Sébastien Penlou (3032496), Laurence Rousset (3032502), Lionel Carles (3032499)   +5 more
core   +1 more source

A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones

Molecules, 2019
Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied.
Federica Arioli, Maria Pérez, Celeste Are, Elies Molins, Joan Bosch, Mercedes Amat   +5 more
doaj   +1 more source

2-Aryl-6-Polyfluoroalkyl-4-Pyrones as Promising R^F-Building-Blocks: Synthesis and Application for Construction of Fluorinated Azaheterocycles

Molecules, 2021
A convenient and general method for the direct synthesis of 2-aryl-6-(trifluoromethyl)-4-pyrones and 2-aryl-5-bromo-6-(trifluoromethyl)-4-pyrones has been developed on the basis of one-pot oxidative cyclization of (E)-6-aryl-1,1,1-trifluorohex-5-ene-2,4 ...
Sergey A. Usachev, Diana I. Nigamatova, Daria K. Mysik, Nikita A. Naumov, Dmitrii L. Obydennov, Vyacheslav Y. Sosnovskikh   +5 more
doaj   +1 more source