Results 61 to 70 of about 5,533 (174)

Design, Synthesis and Antifibrotic Activities of Carbohydrate- Modified 1-(Substituted aryl)-5-trifluoromethyl-2(1H) Pyridones

Molecules, 2012
Pirfenidone, a pyridone compound, is an effective and novel antifibrotic agent. In this article, we describe the design, synthesis and activity evaluation of novel antifibrotic agents, 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones modified with ...
Lijian Tao, Zhongjun Li, Renna Luo, Gaoyun Hu, Qi Hou, Zhiqi Lao, Lingling Xuan, Jinye Bai, Xiangbao Meng, Qinghua Lou   +9 more
doaj   +1 more source

SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences, 2004
4-Chloro-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (3) was reacted with 4-aminoacetophenone in ethanol to give 4(4- acetylanilino)5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (4).
Zakaria Abd El-Samii , Said El-Feky , Hanan Abedel-Fattah , Mahmoud Soliman   +3 more
doaj   +1 more source

Synthesis, properties and colour assessment of some new 5-(3- and 4-substituted phenylazo)-4,6-dimethyl-3-cyano-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2006
A series of 5-(3- and 4-substituted phenylazo)-4,6-dimethyl-3-cyano-2-pyridones were synthesized, starting from acetylacetone and arenediazonium salt, followed by condensation with cyanoacetamide using a modified literature procedure.
DUSAN MIJIN, GORDANA USCUMLIC, NADA PERISIC-JANJIC, IVAN TRKULJA, MAJA RADETIC, PETAR JOVANCIC   +5 more
doaj  

Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines

Molecules, 2005
A series of 1-aryl substituted dihydro-, 5-methyldihydro- and 6-methyl-dihydro-2,4(1H,3H)pyrimidinediones and their 2-thio analogues were obtained byreaction of the corresponding β-alanines or α-methyl- and β-methyl-β-alanines with ureaor ...
Gema Mikulskiene, Vytautas Mickevicius, Rita Vaickelioniene   +2 more
doaj   +1 more source

Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp. [PDF]

Front Chem, 2022
Chang S, Yan B, Chen Y, Zhao W, Gao R, Li Y, Yu L, Xie Y, Si S, Chen M.   +9 more
europepmc   +1 more source

Divergent Synthesis of Functionalized Indenopyridin-2-ones and 2-Pyridones via Benzyl Group Transfer: Two Cases of Aza-semipinacol-Type Rearrangement. [PDF]

Org Lett, 2022
Sośnicki JG, Borzyszkowska-Ledwig A, Idzik TJ, Lubowicz MM, Maciejewska G, Struk Ł.   +5 more
europepmc   +1 more source

Solvatochromism of 5-(4-substituted arylazo)-4-phenyl-6-methyl-3-cyano-2-pyridones

Zaštita Materijala, 2018
Eight 5-(4-substituted arylazo)-4-phenyl-6-methyl-3-cyano-2-pyridones were synthesized by reaction of benzoylacetone and arendiazonium salt, followed by condensation with cyanoacetamide. Absorption spectra of all azo pyridone dyes were recorded in twelve
Gordana S. Ušćumlić, Bojan Đ. Božić   +1 more
doaj   +1 more source

Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics. [PDF]

Proc Natl Acad Sci U S A, 2022
Nye TM, Tükenmez H, Singh P, Flores-Mireles AL, Obernuefemann CLP, Pinkner JS, Sarkar S, Bonde M, Lindgren AEG, Dodson KW, Johansson J, Almqvist F, Caparon MG, Hultgren SJ.   +13 more
europepmc   +1 more source

A Mild and Highly Diastereoselective Preparation of N-Alkenyl-2-Pyridones via 2-Halopyridinium Salts and Aldehydes. [PDF]

J Org Chem, 2021
Shivers GN, Pigge FC.
europepmc   +1 more source

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones. [PDF]

J Org Chem, 2021
Tyagi M, Adolfsson DE, Singh P, Ådén J, Jayaweera SW, Gharibyan A, Bharate JB, Kiss A, Sarkar S, Olofsson A, Almqvist F.   +10 more
europepmc   +1 more source