Results 61 to 70 of about 24,429,900 (206)

Alkoxyallenes in Modern Synthesis: Reactivity, Catalysis, and Complexity Generation

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
The last decade has witnessed a remarkable transformation in alkoxyallene chemistry. Although historically employed as synthetic equivalents of acrolein or as versatile 3C synthons, alkoxyallenes are now increasingly recognized as highly adaptable platforms for synthetic design.
A. Lanfranco, M. Rusconi, J. Saglietto, P. Renzi, A. Deagostino, E. Azzi   +5 more
wiley   +1 more source

Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent Conditions

Chemistry Proceedings, 2023
2-Hydroxypyridines (or commonly named 2-pyridones) are widespread nitrogen heterocycles in natural and synthetic products and their applications in biological, pharmaceutical and agrochemical compounds are becoming increasingly important.
Djamila Benzenine, Fatima Belhadj, Zahira Kibou, M. Pilar Vázquez-Tato, Julio A. Seijas, Noureddine Choukchou-Braham   +5 more
doaj   +1 more source

Kristallstruktur eines 2-Dimethylamino-3,3-dimethyl-4(3H)-pyridons

CHIMIA, 1982
3-Dimethylamino-2,2-dimethyl-2H-azirine (1) reacts with alkyl phenyl substituted cyclopropenones 2 in benzene at 130 °C to give a mixture of the two isomeric 4(3H)-pyridones 3 and 4, resulting from a nucleophilic attack at C(2) and C(1) of the ...
Jost H. Bieri, Roland Prewo, Heinz Heimgartner   +2 more
doaj   +1 more source

Phenacylation of 6-Methyl-Beta-Nitropyridin-2-Ones and Further Heterocyclization of Products

Molecules, 2020
Reaction between the derivatives of 6-methyl-beta-nitropyridin-2-one and phenacyl bromides was studied, and the yields observed were extremely low. The pyridones were converted via chloropyridines to methoxyderivatives, which were N-phenacylated.
Eugene V. Babaev, Victor B. Rybakov
doaj   +1 more source

Synthesis, Characterization, and Biological Assessment of 2‐Methoxynicotinonitrile Derivatives

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
We report the synthesis of new 2‐methoxy‐3‐cyanopyridine derivatives via the nucleophilic aromatic substitution pathway, along with their crystal structure determination and preliminary biological evaluation. The new synthetic conversion described here demonstrates a practical method of preparing structurally diverse 2‐methoxy‐3‐cyanopyridines and ...
Eman Sulaiman, Eman Al‐Masri, Maram B. Alhawarri, Mohammad M. Ibrahim, Mahmoud Al‐Refai, Basem F. Ali, Ali Shuaib   +6 more
wiley   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1278-1290, September 2026.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Avoiding pitfalls when modelling ligands in macromolecular crystallography

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1016-1029, September 2026.
Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart, Andrew Sharff, Claus Flensburg, Clemens Vonrhein, Gérard Bricogne   +4 more
wiley   +1 more source

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones

, 2019
We report the synthesis of 6-arylthio-substituted-N-alkenyl 2-pyridones by ring opening of bicyclic thiazolino-2-pyridones with arynes. Varied functionalization was used to investigate scope and substituent influences on reactivity.
Adolfsson, Dan E.,, Almqvist, Fredrik, Singh, Pardeep,, Sauer, Uwe H.,, Cairns, Andrew G., Ådén, Jörgen,, Ådén, Jörgen, Cairns, Andrew G.,, Singh, Pardeep, Almqvist, Fredrik,, Adolfsson, Dan E., Sauer, Uwe H.   +11 more
core   +1 more source

Identification of New Anti‐Trypanosoma brucei Leads: An Integrated CRK12‐Guided Virtual Screen With Experimental Validation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Qin Li, Chenggong Fu, Jiayi Luo, Qianqian Zhang, Lingling Wang, Xiaomeng Liu, Jiayue Qiu, Xiaoqing Gong, Henry H. Y. Tong, Xiaojun Yao, Dehua Lai, Huanxiang Liu   +11 more
wiley   +1 more source

Synthesis of Densely Functionalized N‑Alkenyl 2‑Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2‑Pyridones

, 2019
We report the synthesis of 6-arylthio-substituted-N-alkenyl 2-pyridones by ring opening of bicyclic thiazolino-2-pyridones with arynes. Varied functionalization was used to investigate scope and substituent influences on reactivity.
Pardeep Singh (294895), Jörgen Ådén (1820980), Dan E. Adolfsson (6483089), Andrew G. Cairns (1282671), Fredrik Almqvist (698391), Uwe H. Sauer (7255691)   +5 more
core   +1 more source