Synthesis, biological activity and electron impact of mass spectra of trisubstituted-2-thiohydantoins [PDF]
3-[1-(2-Hydroxyphenyl)ethylideneamino]-2-thiohydantoin (2) was prepared via cyclization of 2-hydroxyacetophenone thiosemicarbazone (1) with ethyl chloroacetate in the presence of fused sodium acetate. The chemical behaviour of 2 towards acetic anhydride,
Abd El-Meniem, Mohamad +2 more
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ヒト ケツエキチュウ ノ インスリン サヨウ ソクシン タンパクシツ カガクテキ トクセイ ト セイブツ カッセイ [PDF]
this is the author’s version of a work that was accepted for publication in FEBS letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be ...
Aragaki, Naokatu +2 more
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مجلة بغداد للعلومRecently, some prostate cancer patients have acquired resistance to the second -generation drugs (anzalutamide and apalutamide) prescribed for the treatment of this disease due to the emergence of the F876L mutation, which represents a challenge
Qusay Hussein Hays +1 more
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Formation of amino acid derived 2-thiohydantoins - An experimental and theoretical study [PDF]
, 2019 Hydantoins and thiohydantoins derived from amino acids are an interesting subset of compounds that have a wide range of chemical and biological properties.
Markovic, Zoran +4 more
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Synthesis, crystal and supramolecular structure of rac-N-acetyl-2- thiohydantoin-asparagine
Avances en Química, 2014 The title compound, C7H9N3O3S, also known as rac-N-acetyl-5-propionamide-2-thioxo-imidazolidin-4-one, crystallize in the monoclinic system with space group P21/n (Nº14), Z=4, and unit cell parameters a= 9.338 (7) Å, b= 7.545 (5) Å, c= 13.212 (10) Å, E ...
Gerzon E. Delgado +5 more
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Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one [PDF]
, 2013 The polydentate ligand 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one was synthesized in the intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethyl chloroacetate.
Curcic, Milena G. +6 more
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Infra-red Spectra of Substituted 2-Thiohydantoins
, 1971 Infra-red spectra of 2-thiohydantion 3-N-phenyl-, 3-N-o-tolyl-, 3-N-p-tolyl-2-thiohydantoins, in KBr matrix and in dioxane, and of 3-methyl- and 3-ethyl-2-thiohydantoins in KBr matrix and methylenechloriclo medium were recouded. The effect on absorption frequencies of the these compounds in organic phase has been discussed.
P. V. Kamat +2 more
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Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis [PDF]
, 2011 Background: Hydantoin derivatives are very promising candidates to improve the efficacy of anticancer chemotherapy. Previously, we demonstrated that eight hydantoin derivatives inhibited the P-glycoprotein (ABCB1) efflux pump of mouse T-lymphoma cells ...
Amaral, Leonard +6 more
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One-Pot High-throughput Synthesis of N3-Substituted 5-Arylidene-2-Thiohydantoin Amides and Acids. [PDF]
Tetrahedron Lett, 2022 Whitely C, Li Y.
europepmc +1 more source
Synthesis of indole derivatives as novel indoleamine 2,3-dioxygenase (IDO) inhibitors [PDF]
, 2010 Das immunsuppressive Enzym Indoleamine 2,3-dioxygenase, das eine Schlüsselfunktion im Tryptophan- Metabolismus einnimmt, wird seit geraumer Zeit mit Immuntoleranz gegenüber Tumorgewebe in Verbindung gebracht. Es wird in einigen Krebsarten überexprimiert
Moroder, Susanne
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