Results 41 to 50 of about 848 (152)

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Illuminating Tau Aggregates: Multiscale Approaches for Detection, Imaging, and Understanding

Aggregate, Volume 6, Issue 10, October 2025.
This review presents recent advances in molecular imaging of tauopathies, focusing on tau aggregation mechanisms, structural polymorphism, and imaging strategies. It highlights the development of tau‐selective fluorescent probes and PET tracers and explores emerging techniques such as cryo‐EM and super‐resolution imaging, offering a multiscale ...
Kaustubh R. Bhuskute, Jiayi Fan, Amandeep Kaur   +2 more
wiley   +1 more source

5-(2-Methylsulfanylethyl)-3-prop-2-enyl-2-sulfanylideneimidazolidin-4-one

Molbank
An amino acid-derived 2-thiohydantoin, 5-(2-methylsulfanylethyl)-3-prop-2-enyl-2-sulfanylideneimidazolidin-4-one, obtained from l-methionine, was synthesized in a two-step reaction protocol with allyl isothiocyanate.
Petar Stanić, Marko V. Rodić, Biljana Šmit   +2 more
doaj   +1 more source

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

1,2‐Diaza‐1,3‐Dienes as a Multifaceted Synthons for the Synthesis of Heterocycles: A Fifteen‐Years Update

European Journal of Organic Chemistry, Volume 27, Issue 44, November 25, 2024.
1,2‐Diaza‐1,3‐butadienes, also called azoalkenes, have received considerable attention as key synthons for constructing various heterocyclic scaffolds. This minireview summarizes the contribution of our group in this field over the period from 2009 to the present, focusing on the role of the azoene building block in forming the heterocyclic structures.
Lucia De Crescentini, Giacomo Mari, Stefania Santeusanio, Gianfranco Favi, Fabio Mantellini   +4 more
wiley   +1 more source

Chiral Quaternary Ammonium Salt‐Catalyzed Enantioselective Addition Reactions of Hydantoins

Helvetica Chimica Acta, Volume 107, Issue 3, March 2024.
Abstract We herein report a protocol for the asymmetric 1,4‐addition of hydantoins to various Michael acceptors by utilizing Cinchona alkaloid‐based chiral quaternary ammonium salt catalysts. Various products were obtained with moderate to good enantioselectivities and accompanying computational investigations helped to identify key interactions ...
Katharina Röser, Lucas Prameshuber, Sajid Jahangir, Sharath Chandra Mallojjala, Jennifer S. Hirschi, Mario Waser   +5 more
wiley   +1 more source

Dopaminergic neuronal death via necroptosis in Parkinson's disease: A review of the literature

European Journal of Neuroscience, Volume 59, Issue 6, Page 1079-1098, March 2024.
We reviewed the current literature on the potential role of necroptosis, a recently characterized regulated cell death mechanism, in Parkinson's disease (PD) pathogenesis. We summarized findings from studies on necroptosis in PD preclinical models and PD human tissue samples, discussing how manipulating necroptosis might open a novel therapeutic ...
Maria Regoni, Flavia Valtorta, Jenny Sassone   +2 more
wiley   +1 more source

Necrostatin‐1 releasing nanoparticles: In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes

Journal of Biomedical Materials Research Part A, Volume 112, Issue 2, Page 288-295, February 2024.
Abstract Immunoisolation of pancreatic islets in alginate microcapsules allows for transplantation in the absence of immunosuppression but graft survival time is still limited. This limited graft survival is caused by a combination of tissue responses to the encapsulating biomaterial and islets. A significant loss of islet cells occurs in the immediate
Alexandra M. Smink, Juan D. Medina, Bart J. de Haan, Andrés J. García, Paul de Vos   +4 more
wiley   +1 more source

A comparison of the exposure system of glycidol‐related chemicals on the formation of glycidol‐hemoglobin adducts

Food Science &Nutrition, Volume 12, Issue 1, Page 471-480, January 2024.
The exposure systems of glycidol‐related chemicals on the formation of glycidol‐hemoglobin adducts diHOPrVal were compared. DiHOPrVal formation was observed using several chemicals other than glycidol with different behaviors in vitro and in vivo. However, in both cases, the amount of diHOPrVal produced was very small compared with glycidol. This study
Yuko Shimamura, Yuri Wada, Moeka Tashiro, Hiroshi Honda, Shuichi Masuda   +4 more
wiley   +1 more source

Synthesis and molecular modeling studies of new thiohydantoin-triazole hybrids as anticancer agents

Journal of Saudi Chemical Society
The targeted thiohydantoin-triazole hybrid compounds 5a-d and 9a-d were synthesized by the copper-catalyzed click reaction of 2-azido-N-arylacetamides 3a-d with the appropriate alkynes, thiohydantoin moiety linked to a propargyl group.
Wael M. Alamoudi
doaj   +1 more source