Results 41 to 50 of about 24,424,699 (186)
Beilstein Journal of Organic Chemistry, 2019 A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacologically valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed.
Aleksandr I. Kobelev +5 more
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Chemical Reactivity of 2-Thiohydantoin Derivatives
Zeitschrift für Naturforschung B, 1977 Treatment of 5-arylazo-2-thiohydantoins (2 a-c) with formaldehyde and the appropriate amine in ethyl alcohol led to the formation of the corresponding Mannich bases 3a-i. 2 a-c reacted with methyl bromoacetate and/or chloroacetic acid to give the esters 5 a-c and/or the free acids 5d-f, respectively. 5e also obtained by treating 5 b with aqueous sodium
A. F. A. Shalaby +2 more
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Chemistry Central Journal, 2018 A novel series of substituted 2-thiohydantoin incorporated with benzoimidazole, pyrazole, triazole and/or benzoxazole moieties has been synthesized using (E)-3-[1-(4-bromophenyl)ethylideneamino]-2-thioxoimidazolidin-4-one 1 as the key starting material ...
Heba A. Elhady +2 more
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Synthesis and crystal structure of (S)-5-isopropyl-5-methyl-2-thiohydantoin [PDF]
, 2013 (S)-5-Isopropyl-5-methyl-2-thiohydantoin was synthesized by one-pot reaction of α-methyl-L-valine and thiourea in the absence of solvent. The crystal structure of this compound has been determined from single crystal X-ray diffraction data.
Fujinami, Shuhei +8 more
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Advances in Chemistry of Isothiocyanate-derived Colourants
Czech Journal of Food Sciences, 2009 This study is focused on the reactions of isothiocyanates (ITCs) in the presence of amino compounds leading to coloured structures via substituted 2-thiohydantoins.
K. Cejpek, J. Velíšek
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Food Frontiers, Volume 7, Issue 4, July 2026.We provided the first evidence that exposure of general adults to ACR was related to ABI decrement and PAD odds increment, which might be partly associated with accelerated biological aging. Lipid and atherosclerosis pathway may be suggestively implicated in the mechanism underlying these associations.
Feifei Wang +11 more
wiley +1 more source
Green Chemistry Letters and Reviews, 2016 A regioselective N3-alkylation of 5,5-diphenyl-2-thiohydantoin (2-thiophenytoin) using a very efficient mild base K2CO3 and α,β-unsaturated esters in the presence of organic salt TBAB (tetrabutylammonium bromide) at room temperature has been reported (3b–
Gholamhassan Imanzadeh +2 more
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Food Frontiers, Volume 7, Issue 3, May 2026.ABSTRACT Ergothioneine (EGT), a natural thiol derivative, has gained attention as a geroprotective nutraceutical. Preclinical research shows EGT scavenges free radicals, maintains mitochondrial integrity, slows telomere erosion, and regulates proteostasis via autophagy and senescent cell clearance.
Tian‐Tian Tian +3 more
wiley +1 more source
Molecules, 2018 The preparation of 5-methylene-thiohydantoins using solid-phase synthesis is reported in this paper. After sulfonylation of immobilized Ser (t-Bu)-OH with 4-nitrobenzenesulfonyl chloride followed by alkylation with various bromoketones, the 4-Nos group ...
Petra Králová +3 more
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Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds
ChemMedChem, Volume 21, Issue 2, January 2026.Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley +1 more source