Results 21 to 30 of about 850 (153)

A New Polymorph of 2-Thiohydantoin

X-ray Structure Analysis Online, 2009
A new polymorphic crystal of the title compound, C3H4N2OS, belongs to space group P1 with cell dimensions of a = 4.0520(9)A, b = 6.550(1)A, c = 9.170(2)A, α = 100.148(4)°, β = 100.814(4)°, γ = 96.831(4)°, R1 = 0.069. Neighboring molecules are connected to form cyclic dimers via two types of hydrogen bonds, one between the thioamide groups and the other
Ogawa, Toshikazu, Okumura, Hisako, Honda, Mitsunori, Suda, Mitsuhiro, Fujinami, Shuhei, Kuwae, Akio, Hanai, Kazuhiko, Kunimoto, Ko-Ki   +7 more
openaire   +2 more sources

Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models

Archiv der Pharmazie, Volume 355, Issue 5, May 2022., 2022
Structurally distinct enzalutamide‐based proteolysis‐targeting chimeras (PROTACs) were designed, synthesized, and biochemically analyzed. For the first time, androgen receptor degraders were evaluated in lung cancer cells, where significant degradation of the target was observed.
Lukas M. Gockel, Vladlena Pfeifer, Fabian Baltes, Rafael D. Bachmaier, Karl G. Wagner, Gerd Bendas, Michael Gütschow, Izidor Sosič, Christian Steinebach   +8 more
wiley   +1 more source

HYDANTOINS: THE HISTORY OF 2-THIOHYDANTOIN. XXII. [PDF]

Journal of the American Chemical Society, 1913
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openaire   +2 more sources

Synthesis and Fluorescence Mechanism of the Aminoimidazolone Analogues of the Green Fluorescent Protein: Towards Advanced Dyes with Enhanced Stokes Shift, Quantum Yield and Two‐Photon Absorption

European Journal of Organic Chemistry, Volume 2021, Issue 41, Page 5649-5660, November 8, 2021., 2021
Intramolecularly hydrogen‐bonded analogues of the green fluorescence protein chromophore with an aminoimidazole moiety were synthesised and characterised. The fluorescence mechanism and substituent effects were investigated in a combined experimental‐computational approach, and a 279‐fold improvement in the quantum yield was realised.
Ervin Kovács, Levente Cseri, Attila Jancsó, Ferenc Terényi, Anna Fülöp, Balázs Rózsa, Gábor Galbács, Zoltán Mucsi   +7 more
wiley   +1 more source

1-Acetyl-2-thiohydantoin

Acta Crystallographica Section C Crystal Structure Communications, 1998
In the title compound (1-acetyl-4-oxoimidazolidine-2-thione, C5H6N2O2S), the plane of the acetyl group forms an angle of 6.7° with the essentially planar thiohydantoin ring. N—H⋯O hydrogen bonds create quasiplanar chains of molecules along the y axis.
J. S. Casas, A. Castiñeiras, D. Couce, N. Playá, J. Sordo, J. M. Varela   +5 more
openaire   +3 more sources

New platinum(II) complexes of cycloalkanespiro-5-(2-thiohydantoins). Synthesis and quantum chemical investigation

Acta Chimica Slovenica, 2015
Synthesis and characterization of new Pt(II) complexes of cyclohexanespiro-5-(2-thiohydantoin)  (L1) and cycloheptanespiro-5-(2-thiohydantoin) (L2) are discussed. The new complexes are studied by elemental analysis, IR, ATR FTIR spectroscopy.
Petja E. Marinova, Marin Marinov, Vassil Delchev, Neyko Stoyanov   +3 more
doaj   +1 more source

Reactions with 2-Thiohydantoin, Synthesis of Imidazothiazolone Derivatives and Mannich Bases of 5-Arylidene-2-thiohydantoin

Zeitschrift für Naturforschung B, 1976
Treatment of 5-arylidene-2-thiohydantoin (1a-d) with alkyl bromoacetate and chloroacetic acid gave the esters 2a-f and the acids 2g-j, respectively. 2a was refluxed with concentrated hydrochloric acid to give 5-benzylidene hydantoin. 2 was cyclized with acetic anhydride to give the bicyclic product 3. 5-Arylidene-2-thiohydantoin derivatives (1a, b) and
A. F. A. Shalaby, H. A. Daboun, M. A. Abdel Aziz   +2 more
openaire   +1 more source

Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity

Molecules, 2023
Novel variously substituted thiohydantoin-based dispiro-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, and sarcosine.
Yan A. Ivanenkov, Maxim E. Kukushkin, Anastasia A. Beloglazkina, Radik R. Shafikov, Alexander A. Barashkin, Andrey A. Ayginin, Marina S. Serebryakova, Alexander G. Majouga, Dmitry A. Skvortsov, Viktor A. Tafeenko, Elena K. Beloglazkina   +10 more
doaj   +1 more source

Reactivity of 2-Thiohydantoins Towards Various Electrophilic Reagents: Applications to the Synthesis of New 2-Ylidene-3,5-dihydro-4H-imidazol-4-ones.

Molecules, 2004
A new route to 5-(imidazolidin-2-ylidene)-2-methylsulfanyl-3,5-dihydro-imidazol-4-ones 4a-c using ketene dithioacetal intermediates 3a-c is described.
Jean Pierre Bazureau, François Carreaux, Jean-René Chérouvrier   +2 more
doaj   +1 more source

Microwave Assisted Synthesis of Novel Functionalized Hydantoin Derivatives and Their Conversion to 5-(Z) Arylidene-4H-imidazoles

Molecules, 2011
2-(Alkyl-1-yl)-1H-imidazol-5(4H)-ones 5a–n were synthesized via nucleophilic substitution of the methylsulfanyl group of the corresponding 2-(methylthio)-1H-imidazol-5(4H)-ones 3a–c with suitably substituted secondary amines.
Edward R. Biehl, Haribabu Ankati, Sukanta Kamila   +2 more
doaj   +1 more source