Results 11 to 20 of about 848 (152)
A Plausible Prebiotic One-Pot Synthesis of Orotate and Pyruvate Suggestive of Common Protometabolic Pathways. [PDF]
Angew Chem Int Ed Engl, 2022 A prebiotic synthesis of the nucleobase orotate, and the citric acid cycle intermediate pyruvate, proceeds in a single pot from two small glycine derivatives, hydantoin and glyoxylate, under mild aqueous conditions. These findings support a co‐evolution of pathways to core protometabolites and nucleic acid building blocks in a common environment ...
Clay AP +5 more
europepmc +3 more sources
Synthesis and Identification of Heterobivalent Anticancer Compounds Containing Urea and 5-Arylidene-2-Thiohydantoin Motifs. [PDF]
ChemistrySelectA synthetic approach to the synthesis of novel heterobivalent compounds containing urea and 5‐arylthiohydantoin groups was developed for the preparation of a mixture‐based library. Through the screening and deconvolution of the library, six hits with βC branched residues at R1 and imidazyl residue at R3 were identified exhibiting moderate inhibitory ...
Whitely C, Winburn H, Li Y.
europepmc +2 more sources
Reaction of a 3-aryilidene-2-thiohydantoin derivative with polymeric trans-[CuCl2(DMSO)2]n complex: Unexpected isomerization to dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2 [PDF]
Journal of the Serbian Chemical Society, 2020 The 3-arylidene-2-thiohydantoin derivative, 3-[(2-hydroxybenzylidene) amino]-2-thioxoimidazolidin-4-one, was synthesized in a two-step condensation reaction of 2-hydroxybenzaldehyde, thiosemicarbazide and ethyl chloroacetate.
Stanić Petar B. +6 more
doaj +1 more source
SYNTHESES, ANTIMICROBIAL ACTIVITY AND MASS SPECTRAl INVESTIGATION OF SOME NEW THIOHYDANTOIN AND THIAZOLE DERIVATIVES. [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2012 5-(p-Tolyl)-2-[(p-tolylethylidene)hydrazino] thiazole (3) and 3-[(p-tolylethylidene )amino]-2-thiohydantoin (6) have been prepared via cyclization of p-methyl acetophenone thiosemicarbazone (2) with p-methylphenacyl bromide and ethyl chloroacetate ...
haba Abd El Hady
doaj +1 more source
The Chemical Record, Volume 23, Issue 11, November 2023., 2023 Efforst are described for developing Brønsted base‐catalyzed, site‐ and stereoselective α‐functionalization of a variety of unsaturated enolizable carbonyl compounds via transient enolates featuring an extended π‐system. Abstract Chiral Brønsted base (BB) catalyzed asymmetric transformations constitute an important tool for synthesis.
Mikel Oiarbide, Claudio Palomo
wiley +1 more source
Acta Chimica Slovenica, 2020 The present work is directed toward preparation and structural characterization of two novel Cu(I) arylsulfonate π-complexes with 3-allyl-2-thiohydantoin, namely [Cu2(Hath)4](C6H5SO3)2 (1) and [Cu2(Hath)4](p-CH3C6H4SO3)2·2H2O (2) (Hath = 3-allyl-2 ...
Andrii Fedorchuk +3 more
doaj +1 more source
European Journal of Organic Chemistry, Volume 2022, Issue 40, October 26, 2022., 2022 A new strategy has been proposed for the synthesis of an array of imidazo[5,1‐c][1,4]oxazine chemotypes by using a planned aza‐Michael addition in a 3‐CR heteroring‐forming, post‐cyclization transformation followed by an intramolecular fused‐heterocycles formation process.
Giacomo Mari +4 more
wiley +1 more source
A recent update on new synthetic chiral compounds with antileishmanial activity
Chirality, Volume 34, Issue 10, Page 1279-1297, October 2022., 2022 ∎ Abstract Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis, affect billions of people and are responsible for almost 500,000 deaths/year. In particular, leishmaniasis, a neglected tropical disease, is considered a global public health problem because current drugs have several drawbacks including to toxicity, high cost, and ...
Michele Verboni +2 more
wiley +1 more source
Archiv der Pharmazie, Volume 355, Issue 5, May 2022., 2022 Structurally distinct enzalutamide‐based proteolysis‐targeting chimeras (PROTACs) were designed, synthesized, and biochemically analyzed. For the first time, androgen receptor degraders were evaluated in lung cancer cells, where significant degradation of the target was observed.
Lukas M. Gockel +8 more
wiley +1 more source
A New Polymorph of 2-Thiohydantoin
X-ray Structure Analysis Online, 2009 A new polymorphic crystal of the title compound, C3H4N2OS, belongs to space group P1 with cell dimensions of a = 4.0520(9)A, b = 6.550(1)A, c = 9.170(2)A, α = 100.148(4)°, β = 100.814(4)°, γ = 96.831(4)°, R1 = 0.069. Neighboring molecules are connected to form cyclic dimers via two types of hydrogen bonds, one between the thioamide groups and the other
Ogawa, Toshikazu +7 more
openaire +2 more sources