Preliminary Studies of Antimicrobial Activity of New Synthesized Hybrids of 2-Thiohydantoin and 2-Quinolone Derivatives Activated with Blue Light [PDF]
Molecules, 2022 Thiohydantoin and quinolone derivatives have attracted researchers’ attention because of a broad spectrum of their medical applications. The aim of our research was to synthesize and analyze the antimicrobial properties of novel 2-thiohydantoin and 2 ...
Krystian Mokrzyński +2 more
exaly +6 more sources
Synthesis and antibacterial activity of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moieties [PDF]
Saudi Pharmaceutical Journal, 2018 A series of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moiety (28–65) were synthesized by the reaction of (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid chlorides with 5 ...
Nazar Trotsko +4 more
doaj +3 more sources
2-Thiohydantoin Moiety as a Novel Acceptor/Anchoring Group of Photosensitizers for Dye-Sensitized Solar Cells [PDF]
Materials, 2020 Very recently, we have reported the synthesis and evaluation of biological properties of new merocyanine dyes composed of triphenylamine moiety, π-aromatic spacer, and rhodanine/2-thiohydantoin-based moiety.
Przemyslaw Ledwon +2 more
exaly +3 more sources
Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments [PDF]
Molecules, 2022 Inflammation is the main cause of several autoimmune diseases, including type I diabetes, rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple sclerosis.
Salma M. Khirallah +9 more
doaj +2 more sources
A Simple Synthesis of 2-Thiohydantoins [PDF]
Molecules, 2006 2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an α-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
Yulu Zhang +2 more
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In silico and in vivo hepatoprotective activity of the synthesized 5-benzylidene-2-thiohydantoin against diethylnitrosamine-induced liver injury in a rat model [PDF]
Scientific Reports, 2023 In the present study, the hepatoprotective effect of 5-benzylidine-2-thiohydantoin (5B2T), a unique derivative of the thiohydantoin group, on liver injury induced by diethylnitrosamine (DEN) in male rats was investigated.
Lana S. Akree +2 more
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Spiroleiferthione A and Oleiferthione A: Two Unusual Isothiocyanate-Derived Thioketone Alkaloids from Moringa oleifera Lam. Seeds [PDF]
Pharmaceuticals, 2023 Spiroleiferthione A (1), with a 2-thiohydantoin a heterocyclic spiro skeleton, and oleiferthione A (2), an imidazole-2-thione derivative, were isolated from the aqueous extract of Moringa oleifera Lam. seeds.
Yueping Jiang +6 more
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Integrated DFT, molecular docking, and molecular dynamics investigation of some novel 2-thiohydantoin analogues as potent CDK2 inhibitors for anticancer therapy [PDF]
Scientific ReportsCancer progression is driven by dysregulation of cyclin-dependent kinase 2 (CDK2), a critical cell cycle regulator. This study employed an integrated computational approach combining Density Functional Theory (DFT), molecular docking, molecular dynamics (
Nada A. Khaled +5 more
doaj +2 more sources
Enantiodifferentiation of α-Arylacetic Acid and Thiohydantoin Derivatives by NMR Using Thiourea-Based Chiral Solvating Agents [PDF]
MoleculesTwo thiourea-based chiral solvating agents (CSAs), S-1 and S-2, were evaluated for the enantiomeric discrimination of representative α-arylacetic acids by 1H NMR spectroscopy in the presence of DMAP. Enantiomeric discrimination was assessed by monitoring
Sule Erol Gunal
doaj +2 more sources
Dispiroindolinone–Glutarimide Conjugates: Synthesis and Evaluation as Potential Hetero-PROTACs for p53 Reactivation [PDF]
MoleculesA convergent scheme for the preparation of conjugates with the dispiroindolinone-pyrrolidine-thioimidazolone and glutarimide moieties connected via a triazole-containing linker is proposed.
Vladislav S. Polyakov +7 more
doaj +2 more sources