Synthese von 6-Thioxo-1,2,5-oxadiazinan-3-onen und Umwandlung in 3-Amino-2-thiohydantoine und 3-Hydroxy-2-thiohydantoine / Synthesis of 6-Thioxo-1,2,5-oxadiazinan-3-ones and Transformation into 3-Amino-2-thiohydantoins and 3-Hydroxy-2-thiohydantoins [PDF]
6-Thioxo-1,2,5-oxadiazinan-3-ones 5, easily available by cyclic thiocarbonylation of Nα ,Ndisubstituted α-aminocarbohydroxamic acids 4 with 1,1′-thiocarbonyldiimidazole, are transformed by hydrazine or hydroxylamine into 3-amino-2-thiohydantoins 6 and 3-hydroxy-2-thiohydantoins 7.
Detlef Geffken, Alf Ploetz
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This study presents a thorough investigation of chemical outcomes during the reaction of cisplatin and 2-thiohydantoin ligands in the presence of DMSO. Aided by NMR spectroscopy and quantum chemical calculations, the influence of DMSO substitution on the
Petar B. Stanić +6 more
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Recently, some prostate cancer patients have acquired resistance to the second -generation drugs (anzalutamide and apalutamide) prescribed for the treatment of this disease due to the emergence of the F876L mutation, which represents a challenge
Qusay Hussein Hays +1 more
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Synthesis, crystal and supramolecular structure of rac-N-acetyl-2- thiohydantoin-asparagine
The title compound, C7H9N3O3S, also known as rac-N-acetyl-5-propionamide-2-thioxo-imidazolidin-4-one, crystallize in the monoclinic system with space group P21/n (Nº14), Z=4, and unit cell parameters a= 9.338 (7) Å, b= 7.545 (5) Å, c= 13.212 (10) Å, E ...
Gerzon E. Delgado +5 more
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One-Pot High-throughput Synthesis of N3-Substituted 5-Arylidene-2-Thiohydantoin Amides and Acids. [PDF]
Whitely C, Li Y.
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Infra-red Spectra of Substituted 2-Thiohydantoins
Infra-red spectra of 2-thiohydantion 3-N-phenyl-, 3-N-o-tolyl-, 3-N-p-tolyl-2-thiohydantoins, in KBr matrix and in dioxane, and of 3-methyl- and 3-ethyl-2-thiohydantoins in KBr matrix and methylenechloriclo medium were recouded. The effect on absorption frequencies of the these compounds in organic phase has been discussed.
P. V. Kamat +2 more
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Arylsulfonylation of 5, 5-Disubstituted 2-Thiohydantoins
A, Kobayashi, S, Umemoto, A, Kagemoto
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Antidiabetic Potential of Novel 1,3,5-Trisubstituted-2-Thioxoimidazloidin-4-One Analogues: Insights into α-Glucosidase, α-Amylase, and Antioxidant Activities. [PDF]
Khirallah SM +7 more
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A new polymorph of 2-thiohydantoin
A new polymorphic crystal of the title compound, C3H4N2OS, belongs to space group P1 with cell dimensions of a = 4.0520(9)Å, b = 6.550(1)Å, c = 9.170(2)Å, a = 100.148(4)°, b = 100.814(4)°, g = 96.831(4)°, R1= 0.069. Neighboring molecules are connected to form cyclic dimers via two types of hydrogen bonds, one between the thioamide groups and the other ...
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