Results 31 to 40 of about 13,489 (251)

Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma

Biomedicines, 2022
Despite the addition of several new agents to the armamentarium for the treatment of multiple myeloma (MM) in the last decade and improvements in outcomes, the refractory and relapsing disease continues to take a great toll, limiting overall survival ...
Evert Njomen, Allison Vanecek, Theresa A. Lansdell, Ya-Ting Yang, Peter Z. Schall, Christi M. Harris, Matthew P. Bernard, Daniel Isaac, Omar Alkharabsheh, Anas Al-Janadi, Matthew B. Giletto, Edmund Ellsworth, Catherine Taylor, Terence Tang, Sarah Lau, Marc Bailie, Jamie J. Bernard, Vilma Yuzbasiyan-Gurkan, Jetze J. Tepe   +18 more
doaj   +1 more source

20S and 26S proteasome-binding proteins of the rabbit brain: A proteomic dataset

Data in Brief, 2021
Fractions of 26S and 20S proteasomes isolated from the rabbit brain by the method of salt fractionation (salt-induced precipitation) contain intrinsic proteasome proteins responsible for assembly of the core particle and regulatory particle of proteasome
Olga Buneeva, Arthur Kopylov, Svetlana Kaloshina, Victor Zgoda, Alexei Medvedev   +4 more
doaj   +1 more source

An archaeal homolog of proteasome assembly factor functions as a proteasome activator. [PDF]

PLoS ONE, 2013
Assembly of the eukaryotic 20S proteasome is an ordered process involving several proteins operating as proteasome assembly factors including PAC1-PAC2 but archaeal 20S proteasome subunits can spontaneously assemble into an active cylindrical ...
Kentaro Kumoi, Tadashi Satoh, Kazuyoshi Murata, Takeshi Hiromoto, Tsunehiro Mizushima, Yukiko Kamiya, Masanori Noda, Susumu Uchiyama, Hirokazu Yagi, Koichi Kato   +9 more
doaj   +1 more source

Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging

Biomolecules, 2023
Many chronic diseases, including cancer and neurodegeneration, are linked to proteasome dysregulation. Proteasome activity, essential for maintaining proteostasis in a cell, is controlled by the gating mechanism and its underlying conformational ...
Alessandro D’Urso, Roberto Purrello, Alessandra Cunsolo, Danilo Milardi, Caterina Fattorusso, Marco Persico, Maria Gaczynska, Pawel A. Osmulski, Anna Maria Santoro   +8 more
doaj   +1 more source

Serum 20S proteasome levels are associated with disease activity in MPO-ANCA-associated microscopic polyangiitis

BMC Rheumatology, 2020
Background Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation.
Hiroshi Maruyama, Kouichi Hirayama, Marina Yamashita, Kentaro Ohgi, Ryuji Tsujimoto, Mamiko Takayasu, Homare Shimohata, Masaki Kobayashi   +7 more
doaj   +1 more source

The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes [PDF]

FEBS Letters, 1999
PI31 is a previously described inhibitor of 20S proteasomes. Using recombinant PI31 we have analyzed its effect on proteasomal hydrolyzing activity of short fluorogenic substrates and of a synthetic 40‐mer polypeptide. In addition, we investigated its influence on the activation of 20S proteasome by the proteasome activator PA28.
Zaiss, D M, Standera, Sybille, Holzhütter, H, Kloetzel, P.M., Sijts, A J   +4 more
openaire   +3 more sources

The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes

Redox Biology, 2013
The main machinery responsible for cellular protein maintenance is the ubiquitin-proteasomal system, with its core particle the 20S proteasome. The main task of the system is a fast and efficient degradation of proteins not needed anymore in cellular ...
Tobias Jung, Tilman Grune
doaj   +1 more source

Method of Monitoring 26S Proteasome in Cells Revealed the Crucial Role of PSMA3 C-Terminus in 26S Integrity

Biomolecules, 2023
Proteasomes critically regulate proteostasis via protein degradation. Proteasomes are multi-subunit complexes composed of the 20S proteolytic core particle (20S CP) that, in association with one or two 19S regulatory particles (19S RPs), generates the ...
Shirel Steinberger, Julia Adler, Yosef Shaul   +2 more
doaj   +1 more source

The β-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation

mSphere, 2022
Mycobacterium tuberculosis possesses a Pup-proteasome system analogous to the eukaryotic ubiquitin-proteasome pathway. We have previously shown that the hexameric mycobacterial proteasome ATPase (Mpa) recruits pupylated protein substrates via ...
Xiansha Xiao, Xiang Feng, Jin Hee Yoo, Amanda Kovach, K. Heran Darwin, Huilin Li   +5 more
doaj   +1 more source

Minimal mechanistic component of HbYX-dependent proteasome activation that reverses impairment by neurodegenerative-associated oligomers

Communications Biology, 2023
The implication of reduced proteasomal function in neurodegenerative diseases combined with studies showing the protective effects of increasing proteasome activity in animal models highlight the need to understand the capacity for proteasome activation ...
Janelle J. Y. Chuah, Tiffany A. Thibaudeau, David M. Smith   +2 more
doaj   +1 more source