Regulation of Autophagic Flux by the 20S Proteasome [PDF]
Cell Chemical Biology, 2019 The proteolytic arm of the protein homeostasis network is maintained by both the ubiquitin-proteasome system (UPS) and autophagy. A well-balanced crosstalk between the two catabolic pathways ensures energy-efficient maintenance of cellular function. Our current understanding of the crosstalk between the UPS and autophagy is centered around substrate ...
Jetze J Tepe
exaly +3 more sources
The preliminary study suggests an association between NF-ĸB pathway activation and increased plasma 20S proteasome activity in intracranial aneurysm patients [PDF]
Scientific ReportsThe significant role of increased activation of 20S proteasomes in the development of abdominal aortic aneurysms has been well-established in a mouse model. The available literature lacks similar studies concerning brain aneurysms.
Joanna Kamińska +12 more
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Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity [PDF]
iScienceSummary: In addition to the degradation of cell-cycle proteins, short-lived, damaged, or unfolded proteins are constantly cleared from cells by the proteasome.
Gabriel Ruiz-Romero +4 more
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In vitro Reconstitution Assays of Arabidopsis 20S Proteasome
Bio-Protocol, 2021 The majority of cellular proteins are degraded by the 26S proteasome in eukaryotes. However, intrinsically disordered proteins (IDPs), which contain large portions of unstructured regions and are inherently unstable, are degraded via the ubiquitin ...
Yanjun Li +4 more
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Cells, 2022 The degradation of intrinsically disordered proteins (IDPs) by a non-26S proteasome process does not require proteasomal targeting by polyubiquitin.
Assaf Biran +7 more
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Effects of an anticarcinogenic Bowman-Birk protease inhibitor on purified 20S proteasome and MCF-7 breast cancer cells. [PDF]
PLoS ONE, 2014 Proteasome inhibitors have been described as an important target for cancer therapy due to their potential to regulate the ubiquitin-proteasome system in the degradation pathway of cellular proteins.
Larissa da Costa Souza +5 more
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Applied Sciences, 2021 The ubiquitin–proteasome system (UPS) participates in the degradation of proteins which play an important role in regulating the cell cycle, apoptosis, and angiogenesis, as well as in the immune system.
Anna Sankiewicz +2 more
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Inhibition of the host proteasome facilitates papaya ringspot virus accumulation and proteosomal catalytic activity is modulated by viral factor HcPro. [PDF]
PLoS ONE, 2012 The ubiquitin/26S proteasome system plays an essential role not only in maintaining protein turnover, but also in regulating many other plant responses, including plant-pathogen interactions.
Nandita Sahana +7 more
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Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities
Antioxidants, 2021 Oxidized, damaged and misfolded proteins accumulate during aging and contribute to impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular clearance mechanisms like the 20S proteasome.
Irene Martínez de Toda +3 more
doaj +1 more source
The YΦ motif defines the structure-activity relationships of human 20S proteasome activators
Nature Communications, 2022 The proteasome complexes, composed of 20S core particles and one or two regulatory particles (proteasome activators), degrade most eukaryotic proteins. Here, the authors identify a sequence motif and resolve its interactions mediating the activation of ...
Kwadwo A. Opoku-Nsiah +6 more
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