Results 11 to 20 of about 80,587 (292)
Inhibitory Effect of b-AP15 on the 20S Proteasome
Biomolecules, 2014 The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of
Li Huang, Katherine Jung, Chin Ho Chen
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Effects of an anticarcinogenic Bowman-Birk protease inhibitor on purified 20S proteasome and MCF-7 breast cancer cells. [PDF]
PLoS ONE, 2014 Proteasome inhibitors have been described as an important target for cancer therapy due to their potential to regulate the ubiquitin-proteasome system in the degradation pathway of cellular proteins.
Larissa da Costa Souza +5 more
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Nostocyclopeptides as New Inhibitors of 20S Proteasome. [PDF]
Biomolecules, 2021 Nostocyclopeptides (Ncps) are a small class of bioactive nonribosomal peptides produced solely by cyanobacteria of the genus Nostoc. In the current work, six Ncps were isolated from Nostoc edaphicum strain CCNP1411. The bioactivity of these compounds was tested in vitro against 20S proteasome, a proteolytic complex that plays an important role in ...
Fidor A +6 more
europepmc +6 more sources
Cells, 2022 The degradation of intrinsically disordered proteins (IDPs) by a non-26S proteasome process does not require proteasomal targeting by polyubiquitin.
Assaf Biran +7 more
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Applied Sciences, 2021 The ubiquitin–proteasome system (UPS) participates in the degradation of proteins which play an important role in regulating the cell cycle, apoptosis, and angiogenesis, as well as in the immune system.
Anna Sankiewicz +2 more
doaj +1 more source
Inhibition of the host proteasome facilitates papaya ringspot virus accumulation and proteosomal catalytic activity is modulated by viral factor HcPro. [PDF]
PLoS ONE, 2012 The ubiquitin/26S proteasome system plays an essential role not only in maintaining protein turnover, but also in regulating many other plant responses, including plant-pathogen interactions.
Nandita Sahana +7 more
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Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities
Antioxidants, 2021 Oxidized, damaged and misfolded proteins accumulate during aging and contribute to impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular clearance mechanisms like the 20S proteasome.
Irene Martínez de Toda +3 more
doaj +1 more source
The YΦ motif defines the structure-activity relationships of human 20S proteasome activators
Nature Communications, 2022 The proteasome complexes, composed of 20S core particles and one or two regulatory particles (proteasome activators), degrade most eukaryotic proteins. Here, the authors identify a sequence motif and resolve its interactions mediating the activation of ...
Kwadwo A. Opoku-Nsiah +6 more
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The 20S Proteasome of Streptomyces coelicolor [PDF]
Journal of Bacteriology, 1998 ABSTRACT 20S proteasomes were purified from Streptomyces coelicolor A3(2) and shown to be built from one α-type subunit (PrcA) and one β-type subunit (PrcB). The enzyme displayed chymotrypsin-like activity on synthetic substrates and was sensitive to peptide aldehyde and peptide vinyl sulfone inhibitors ...
Nagy, I. +4 more
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Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases [PDF]
Molecular Cell, 2008 Substrates enter the cylindrical 20S proteasome through a gated channel that is regulated by the ATPases in the 19S regulatory particle in eukaryotes or the homologous PAN ATPase complex in archaea. These ATPases contain a conserved C-terminal hydrophobic-tyrosine-X (HbYX) motif that triggers gate opening upon ATP binding.
Rabl, Julius +5 more
openaire +2 more sources