Results 61 to 70 of about 80,587 (292)
Structural fraction of the PbaB-20S proteasome complexes.
, 2013 Structural fraction of the PbaB-20S proteasome complexes.
Tsunehiro Mizushima (392715) +9 more
core +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Association between abdominal muscle areas and 20S proteasome levels.
, 2015 Association between abdominal muscle areas and 20S proteasome levels.
Ryuichi Furuya (710369) +6 more
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
The effects of Parkinson's disease mimetics on the proteasomal and neurofilament systems in SH-SY5Y cells [PDF]
, 2006 Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson's disease, linked recently to proteasomal dysfunction.
Caneda-Ferrón, B +1 more
core
PbaB tetramer caps the heptameric α subunit ring of the 20S proteasome.
, 2013 Class averages of the PbaB-20S proteasome complexes; (A) the 20S proteasome doubly capped with PbaB on both sides, (B) and (C) the 20S proteasome singly capped with PbaB on one side. Scale bar indicates 10 nm. Three-dimensional tomograms for the PbaB-20S
Tsunehiro Mizushima (392715) +9 more
core +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
PbaB binds the mature 20S proteasome through its HbYX motif.
, 2013 (A and B) PbaB binds to the mature 20S proteasomes (A) αβ1 form and (B) αβ1β2 form but PbaA does not. The non-tagged PbaA and/or PbaB were mixed with the mature 20S proteasome [His6-tagged inactive mutants shown as His6-20S(αβ1) and His6-20S(αβ1β2 ...
Tsunehiro Mizushima (392715) +9 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source