Results 191 to 200 of about 9,716 (212)

The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells

Brain Research, 1999
Neurodegenerative disorders are characterized by a massive loss of nerve cells. The neuronal cell death is accompanied by an increased cholesterol release and conversion of cholesterol into the polar metabolite, 24-hydroxycholesterol (24-OH-Chol), appears to be an important mechanism in the central nervous system for eliminating cholesterol from the ...
H, Kölsch, D, Lütjohann, A, Tulke, I, Björkhem, M L, Rao   +4 more
openaire   +2 more sources

The role of 24S-hydroxycholesterol in Alzheimer's disease.

The journal of nutrition, health & aging, 2003
Studies on Alzheimer's disease (AD) revealed that cholesterol metabolism might be involved in the pathogenesis of this neurodegenerative disorder. The apolipoprotein E4 genotype is a known risk factor in AD. Elevated serum cholesterol concentrations are detected in patients with AD and two recent epidemiological studies have indicated that treatment ...
H, Kölsch, D, Lütjohann, K, von Bergmann, R, Heun   +3 more
openaire   +1 more source

Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993
Although two hepatic sterol metabolites, 24(S)-hydroxycholesterol and 24(S),25-epoxycholesterol, are thought to be important regulators of cholesterol biosynthesis, nothing is known of their degradation and disposal in liver, nor of the mechanisms that regulate their levels.
Saucier, S E, Kandutsch, A A, Clark, D S, Spencer, T A   +3 more
openaire   +2 more sources

Implication du canal potassium Kv3.1 dans la lipotoxicité du 7-cétocholestérol, 24S-hydroxycholestérol et de l’acide tétracosanoïque sur des cellules nerveuses 158N et BV-2 : Etude des relations entre Kv3.1, homéostasie potassique et métabolisme peroxysomal dans la maladie d’Alzheimer

, 2017
Le potassium (K+) est impliqué dans la régulation de l’excitabilité cellulaire, la régulation du cycle cellulaire, la viabilité cellulaire, la neuroprotection et le maintien des fonctions microgliales et oligodendrocytaires.
Maryem Bezine
semanticscholar   +1 more source

Neuron survival modulated by 24-hydroxycholesterol: the role of sirtuin pathway in Alzheimer's Disease

Free Radical Biology and Medicine, 2016
Alzheimer’s disease (AD) is a devastating neurodegenerative condition typified by the pathological accumulation of amyloid β peptides and neurofibrillary tangles of hyperphosphorylated Tau protein within the brain. Moreover, Tau acetylation is abnormally high in the brains of AD patients, even in the early stage of the disease.
GAMBA, Paola Francesca, TESTA, GABRIELLA, STAURENGHI, ERICA, GARGIULO, Simona, ROSSIN, DANIELA, POLI, Giuseppe, LEONARDUZZI, Gabriella Marisa   +6 more
openaire   +2 more sources

D14 Plasma levels of 24S-hydroxycholesterol are reduced in Huntington disease subjects: preliminary results of a 2-year longitudinal study

I D, 2022
M. Fichera, L. Nanetti, M. Favagrossa, A. Castaldo, A. Nigri, A. Mongelli, Gloria Marchini, C. Gellera, M. Grisoli, G. Birolini, M. Valenza, R. Bagnati, A. Passoni, L. Colombo, E. Cattaneo, M. Salmona, C. Mariotti   +16 more
semanticscholar   +1 more source

Absolute configurations of 24-hydroxycholesterol and related compounds

Tetrahedron Letters, 1975
Naoyuki Koizumi, Masuo Morisaki, Nobuo Ikekawa, Atsuo Suzuki, Toru Takeshita   +4 more
openaire   +1 more source

The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease.

Advances in Experimental Medicine and Biology
Domenico Tripodi, Federica Vitarelli, Simona Spiti, Valerio Leoni   +3 more
semanticscholar   +1 more source

24S‐hydroxycholesterol: Cellular effects and variations in brain diseases

Journal of Neurochemistry, 2021
Alejandro O Sodero
exaly  

24S‐hydroxycholesterol suppresses neuromuscular transmission in SOD1(G93A) mice: A possible role of NO and lipid rafts

Molecular and cellular neurosciences, 2018
K. A. Mukhutdinova, M. R. Kasimov, A. Giniatullin, Guzel F. Zakyrjanova, A. Petrov   +4 more
semanticscholar   +1 more source