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The controversial role of 24S-hydroxycholesterol in Alzheimer's disease
Free Radical Biology and Medicine, 2023 P. Gamba +6 more
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Cholesterol and 24S-hydroxycholesterol trafficking in Alzheimer’s disease
Expert Review of Neurotherapeutics, 2006Cholesterol and the cholesterol oxide 24S-hydroxycholesterol (24S-HC) are highly enriched in the human CNS. Clinical, genetic, neurochemical and epidemiological evidence continue to support dysfunctional cholesterol metabolism as an important contributing factor driving the development and/or progression of Alzheimer's disease (AD) neuropathology ...
Walter J Lukiw
exaly +3 more sources
Journal of Mass Spectrometry, 2022
24S-hydroxycholesterol (i.e., cerebrosterol, 24S-OH-Chol) is the main form of cholesterol elimination from the brain. Liquid chromatography-tandem mass spectrometry methods were developed for the quantification of the total and unesterified/unbound ...
V. Brousseau +5 more
semanticscholar +1 more source
24S-hydroxycholesterol (i.e., cerebrosterol, 24S-OH-Chol) is the main form of cholesterol elimination from the brain. Liquid chromatography-tandem mass spectrometry methods were developed for the quantification of the total and unesterified/unbound ...
V. Brousseau +5 more
semanticscholar +1 more source
Advances in Experimental Medicine and Biology, 2023
Neuropsychiatric diseases (NPDs) are severe, debilitating psychiatric conditions that affect the nervous system. These are among the most challenging disorders in medicine. Some examples include Alzheimer's, anxiety disorders, autism spectrum disorder, bipolar disorder, and schizophrenia.
Meriam Messedi, Fatma Makni-Ayadi
semanticscholar +3 more sources
Neuropsychiatric diseases (NPDs) are severe, debilitating psychiatric conditions that affect the nervous system. These are among the most challenging disorders in medicine. Some examples include Alzheimer's, anxiety disorders, autism spectrum disorder, bipolar disorder, and schizophrenia.
Meriam Messedi, Fatma Makni-Ayadi
semanticscholar +3 more sources
24S-Hydroxycholesterol: a Marker of Brain Cholesterol Metabolism
Pharmacopsychiatry, 2003The enzymatic conversion of CNS cholesterol to 24S-hydroxycholesterol, which readily crosses the blood-brain barrier, is the major pathway for brain cholesterol elimination and brain cholesterol homeostasis maintenance. The enzyme mediating this conversion has been characterized at the molecular level (CYP46) and is mainly located in neurons.
D, Lütjohann, K, von Bergmann
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NeuroReport, 2000
The conversion of brain cholesterol into 24S-hydroxycholesterol and its subsequent release into the periphery is probably an important step for the maintenance of brain cholesterol homeostasis. Recent findings suggest that plasma 24S-hydroxycholesterol may be elevated in Alzheimer's disease (AD) and vascular dementia at least at some stage of the ...
Papassotiropoulos, A. +9 more
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The conversion of brain cholesterol into 24S-hydroxycholesterol and its subsequent release into the periphery is probably an important step for the maintenance of brain cholesterol homeostasis. Recent findings suggest that plasma 24S-hydroxycholesterol may be elevated in Alzheimer's disease (AD) and vascular dementia at least at some stage of the ...
Papassotiropoulos, A. +9 more
openaire +2 more sources
Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
Neuroscience Letters, 2000The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance.
Brétillon, Lionel +9 more
openaire +3 more sources