Results 181 to 190 of about 9,716 (212)

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia.

Journal of Psychiatric Research, 2002
The brain is the most cholesterol-rich organ in the human body. Accumulation of excess cholesterol in hippocampal neurons promotes the cleavage of the amyloid precursor protein (APP) into amyloidogenic components with the consequence of the acceleration of neuronal degeneration.
A. Papassotiropoulos, Dieter Lütjohann, Dieter Lütjohann, M. Bagli, S. Locatelli, F. Jessen, R. Buschfort, U. Ptok, I. Björkhem, K. Bergmann, R. Heun   +10 more
semanticscholar   +3 more sources

24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases.

Biochimie, 2013
Brain cholesterol is mainly involved in the cell membrane structure, in signal transduction, neurotransmitter release, synaptogenesis and membrane trafficking. Impairment of brain cholesterol metabolism was described in neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer and Huntington Diseases.
V. Leoni, C. Caccia
semanticscholar   +4 more sources

Diagnostic Power of 24S-Hydroxycholesterol in Cerebrospinal Fluid: Candidate Marker of Brain Health

Journal of Alzheimer’s Disease, 2013
We evaluated the diagnostic potential of 24S-hydroxycholesterol (24OHC) in cerebrospinal fluid. At a memory clinic, we investigated subjects with subjective cognitive impairment (SCI, n = 33), mild cognitive impairment (MCI) patients (n = 27), MCI patients with later progression into Alzheimer dementia at follow up (n = 10), and patients ...
V. Leoni, A. Solomon, A. Lövgren-Sandblom, L. Minthon, K. Blennow, O. Hansson, L. Wahlund, M. Kivipelto, I. Björkhem   +8 more
semanticscholar   +4 more sources

24‐Hydroxycholesterol levels in human brain¹

Journal of Neurochemistry, 1972
24‐Hydroxycholesterol (cerebrosterol, cholest‐5‐ene‐3β;, 24ξ‐diol) occurs at low levels in human (Di Frisco, De Ruggieri and Ercoli, 1953; Ercoli and De Ruggieri, 1953a, 19536; Schubert, Rose and Burger, 1961; Van Lier and Smith, 1969, 1970), equine (Ercoli, Di Frisco and De Ruggieri, 1953a; Ercoli and De Ruggieri, 1953a, 1953b; Fieser, Huang and ...
Leland L. SMITH, D. R. Ray, J. A. Moody, J. D. Wells, J. E. Van Lier   +4 more
openaire   +1 more source

Lecithin cholesterol acyltransferase esterifies 24s-hydroxycholesterol in cerebrospinal fluid

2010
Alteration of cholesterol (Ch) homeostasis is involved in the pathogenesis of neurodegeneration. Astrocyte-derived lecithin cholesterol acyltransferase (LCAT) was recently shown capable of esterifying Ch on ApoE-lipoproteins.In order to prevent Ch excess in neurons, it can be converted in 24Shydroxycholesterol (24-OH Ch).
CIGLIANO, LUISA, Spagnuolo M. S., Maresca B., Pugliese C. R., La Marca V., ABRESCIA, PAOLO   +5 more
openaire   +3 more sources

24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells

NeuroReport, 2005
24S-hydroxycholesterol, the primary oxidation product of cholesterol in the brain, plays a key role in cholesterol elimination and homeostasis. While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease.
Piotr, Alexandrov, Jian-Guo, Cui, Yuhai, Zhao, Walter J, Lukiw   +3 more
openaire   +2 more sources

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease [PDF]

Brain, 2008
Huntington's disease (HD) is a hereditary neurodegenerative disorder for which biological indicators of disease progression, or disease stage, would be especially important for therapeutic trials. 24S-hydroxycholesterol (24OHC) is a brain-generated cholesterol metabolite which has been associated with neurodegeneration, and alterations of cholesterol ...
Valerio Leoni, Caterina Mariotti, Marta Mv Valenza   +2 more
exaly   +5 more sources

Degradation of 24S-hydroxycholesterol in men is not regulated by CYP7A1

Int. Journal of Clinical Pharmacology and Therapeutics, 2007
The conversion of cholesterol into bile acids occurs via a long cascade of enzymatically regulated oxidative processes. Our aim was to examine if an up-regulation of hepatic cholesterol 7alpha-hydroxylase (CYP7A1) in humans by cholestyramine, a bile acid-binding resin, has an effect on the degradation of brain-specific 24S-hydroxycholesterol.Six ...
C, Knabe, T, Sudhop, K, von Bergmann, D, Lütjohann   +3 more
openaire   +2 more sources

24S‐hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis

Journal of Neuroscience Research, 2007
AbstractLevels of the brain‐specific cholesterol metabolite 24S‐hydroxycholesterol are proposed as possible biomarkers for multiple sclerosis (MS). It is not yet clear for which aspect of the MS disease manifestations 24S‐hydroxycholesterol is a reflection.
Teunissen, C E, Floris, S, Sonke, M, Dijkstra, C D, De Vries, H E, Lütjohann, D   +5 more
openaire   +4 more sources

24S-hydroxycholesterol alters activity of large-conductance Ca2+-dependent K+ (slo1 BK) channel through intercalation into plasma membrane.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2019
Oxysterols, oxidization products of cholesterol, are regarded as bioactive lipids affecting various physiological functions. However, little is known of their effects on ion channels.
Nobuyoshi Tajima, L. Xiaoyan, M. Taniguchi, N. Kato   +3 more
semanticscholar   +1 more source