Results 51 to 60 of about 62,607,340 (217)

Gama-glutamil transpeptidase como alvo de ação da 1,25(OH)2 vitamina D3 na membrana plasmática das células de Sertoli [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2014A 1a,25-diidroxivitamina D3 (1,25-D3) é o metabólito ativo da vitaminaD3. A 1,25-D3 é crítica para
Gonçalves, Renata
core  

Effects of 1,25-Dihydroxyvitamin D3 and 25-Hydroxyvitamin D3 on PBMCs From Dairy Cattle Naturally Infected With Mycobacterium avium subsp. paratuberculosis

Frontiers in Veterinary Science, 2022
The role of vitamin D3 in modulating immune responses has been well-established for over two decades; however, its specific functions have not been extensively detailed in cattle, particularly cattle in different stages of infection with Mycobacterium ...
Taylor L. T. Wherry, Taylor L. T. Wherry, Shankumar Mooyottu, Judith R. Stabel   +3 more
doaj   +1 more source

Helicobacter pylori Infection Remodels Neutrophil‐Derived Extracellular Vesicles, Promoting Stress and Apoptosis in Infected Epithelial Cells

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
We report that Helicobacter pylori reprograms neutrophils to release extracellular vesicles (HPN‐EVs) with distinct biophysical and molecular features. These neutrophil‐derived vesicles, enriched in neutrophil granule proteins, LL‐37 and pro‐apoptotic miRNAs, suppress epithelial PI3K/Akt signalling, increase ROS, and induce mitochondrial dysfunction ...
Anand Kumar Keshri, Suraj Singh Rawat, Durganand Thakur, Swati Sharma, Parul Mehra, Anubha Chaudhary, Ananaya Kapoor, Amit Prasad   +7 more
wiley   +1 more source

Effects of Single Vitamin D Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency [PDF]

Endocrinology and Metabolism, 2017
BackgroundVitamin D deficiency remains common in all age groups and affects skeletal and non-skeletal health. Fibroblast growth factor 23 is a bone-derived hormone that regulates phosphate and 1,25-dihydroxyvitamin D homeostasis as a counter regulatory ...
Dongdong Zhang, Da Hea Seo, Han Seok Choi, Hye-Sun Park, Yoon-Sok Chung, Sung-Kil Lim   +5 more
doaj   +1 more source

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Takeshi Marumo, Toshiro Fujita   +6 more
wiley   +1 more source

Vitamin D: Physiology, Pharmacology and Clinical Evidence for Supplementation—A Narrative Review

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Vitamin D is a nutrient and prohormone obtained from diet and supplements and synthesized in the skin. It is essential for calcium and phosphate homeostasis and skeletal health and influences multiple extra‐skeletal processes, yet deficiency remains common worldwide.
Jyrki K. Virtanen
wiley   +1 more source

Calvarial cells synthesize 1 alpha,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3

, 1983
A metabolite of vitamin D has been isolated in pure form from incubation of 25-hydroxyvitamin D3 with embryonic chick calvarial cells that had been grown on Cytodex 1 microcarrier beads.
Turner, R T, Baylink, D J, Knapp, D R, Howard, G A, Puzas, J E   +4 more
core   +1 more source

Serum Vitamin D Levels at Birth Are Not Associated With the Formation of Interglobular Dentin in Deciduous Teeth of Modern New Zealand Children

American Journal of Biological Anthropology, Volume 191, Issue 2, October 2026.
ABSTRACT Interglobular dentin (IGD) has been used as a biomarker for vitamin D deficiency (VDD) in past populations. However, an evidence‐based threshold for the levels of serum vitamin D associated with IGD occurrence has not been established. Here, we explore the association between perinatal serum vitamin D levels, presence of IGD, and biological ...
Anne Marie Sohler‐Snoddy, Stephanie Chan, Rebecca Weastell, Victoria Chen, Benjamin J. Wheeler, Deanna Beckett, Carolina Loch   +6 more
wiley   +1 more source

The Effects of 24R, 25-Dihydroxyvitamin D3 and 24S, 25-Dihydroxyvitamin D3 on Phosphate Transport in Vivo

, 2011
The steroid hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] rapidly stimulates the uptake of phosphate in isolated chick intestinal cells, while the steroid 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] inhibits the rapid stimulation by 1,25(OH)2D3. Previous work in this laboratory has indicated that 24,25(OH)2D3 inhibits phosphate uptake in isolated ...
openaire   +2 more sources

Comparison of 26,27-Hexafluoro-1.ALPHA.,25-dihydroxyvitamin D3 and 1.ALPHA.,25-Dihydroxyvitamin D3 on the Resorption of Bone Explants Ex Vivo.

Journal of Nutritional Science and Vitaminology, 1999
26,27-Hexafluoro-1 alpha,25-dihydroxyvitamin D3 [F6-1,25-(OH)2D3] is more potent than 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3] in stimulating bone resorption in vitro and in vivo. The reason why F6-1,25(OH)2D3 is more active remains unclear.
MIYAHARA, Tatsuro, HARADA, Masahiro, KOZAKAI, Akinori, MATSUMOTO, Masa-aki, HASHIMOTO, Kazuhiro, INOUE, Hirohumi, YODA, Kayo, NAKATSU, Takumi, KAJITA, Sumiyo, YAMAZAKI, Ryuzaburo, HIGUCHI, Syouhei, KOZUKA, Hiroshi, NEMOTO, Nobuo   +12 more
openaire   +3 more sources