Results 71 to 80 of about 62,607,340 (217)

Ciliary Ift20 and Wwtr1 Coordinate Transforming Growth Factor‐β Receptor II Signaling to Maintain Bone–Fat Balance in Skeletal Homeostasis

MedComm, Volume 7, Issue 10, October 2026.
Deletion of Ift20 and Wwtr1 in osteoprecursors promoted adipogenic differentiation while suppressing osteogenesis and bone remodeling through dysregulation of TGF‐β signaling. Mechanistically, Ift20 stabilized TβRII by inhibiting c‐Cbl‐mediated ubiquitination and proteasomal degradation. In parallel, Wwtr1 functioned as a transcriptional regulator that
Yang Li, Yang Yang, Shuting Yang, Huijuan Chang, Yi‐Ping Li, Shuying Yang   +5 more
wiley   +1 more source

1α,25-dihydroxyvitamin D3 promotes osteogenic activity and downregulates proinflammatory cytokine expression in human periodontal ligament cells.

, 2015
The aim of this study was to assess the impact of 1α,25-dihydroxyvitamin D3 (vitamin D3) on osteogenic and inflammatory properties of human periodontal ligament (PDL) cells and investigate underlying ...
Jönsson, Daniel, Arosenius, Karin,, Nilsson, B. -O., Nilsson, Bengt-Olof,, Larsson, E., Svensson, Daniel, Svensson, D., Svensson, Daniel,, Larsson, E, Arosenius, K, Nebel, Daniel, Nebel, Daniel,, Nilsson, Bengt-Olof, Lund University., Jönsson, Daniel,   +14 more
core   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Maternal Vitamin D Deficiency is Associated With Sex‐Dependent Alterations in Neurodevelopment‐Related Gene Expression, Particularly in the Hypothalamus

Molecular Nutrition &Food Research, Volume 70, Issue 20, 28 October 2026.
Maternal vitamin D deficiency (VDD) affects early brain development in a sex‐dependent manner. VDD accelerates neuronal differentiation and synaptogenesis. Male offspring exhibit broader transcriptomic alterations, including dysregulation of melanocortin‐pathway and synaptic signaling genes, indicating greater vulnerability of hypothalamic circuits ...
Lidia Saidi, Emmanuel Snacel‐Fazy, Eva Seipelt, Nicole Haroun, Julien Astier, Charlène Couturier, Mohamed El Soltani, Eric Sérée, Flavie Sicard, Habib Hammou, Michel Puceat, Jean‐François Landrier, Lourdes Mounien   +12 more
wiley   +1 more source

Effects of 1alpha, 25-dihydroxyvitamin D3 on programmed cell death of Ishikawa endometrial cancer cells through ezrin phosphorylation

, 2017
This study investigated the effects of 1α, 25-dihydroxyvitamin D3-induced cell death and its underlying molecular mechanisms in Ishikawa endometrial carcinoma cells.
Junsik Park, Hae-Hyeog Lee, Jeong-Sang Lee, Tae-Hee Kim   +3 more
core   +1 more source

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani, Ramin Yaghobi, Mohsen Khosravi Maharlooei, Mehdi Golshan, Mohammad Hossein Karimi   +4 more
wiley   +1 more source

Biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3

, 1983
The biological activity of 24,24-difluoro-1,25-dihydroxyvitamin D3 was compared with 1,25-dihydroxyvitamin D3 in the rat. The 24,24-difluoro-1,25-dihydroxyvitamin D3 has a potency of approximately 5-10 times that of 1,25-dihydroxyvitamin D3 in the known ...
S. Okamoto, N. Ikekawa, Y. Tanaka, Y. Kobayashi, H. F. DeLuca   +4 more
core   +1 more source

Vitamin D Deficiency During Pregnancy Is Associated With Greater LDL‐C Increase, Elevated β‐Hydroxybutyrate and Altered Neonatal Metabolic Markers—A Secondary, Pooled Analysis of the Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Early pregnancy vitamin D deficiency in women with overweight or obesity is associated with greater increases in LDL cholesterol and ketone bodies during gestation, as well as higher cord blood ketone levels in offspring. These findings suggest a role of maternal vitamin D status in shaping metabolic adaptations in pregnancy and fetal exposure ...
Jürgen Harreiter, Teresa Gisinger, Lilian C. Mendoza, David Simmons, Gernot Desoye, Roland Devlieger, Sander Galjaard, Peter Damm, Elisabeth R. Mathiesen, Dorte M. Jensen, Lise Lotte T. Andersen, Fidelma Dunne, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Ewa Wender‐Ozegowska, Agnieszka Zawiejska, David Hill, Judith G. M. Jelsma, Frank J. Snoek, Christof Worda, Dagmar Bancher‐Todesca, Mireille N. M. van Poppel, Rosa Corcoy, Alexandra Kautzky‐Willer   +24 more
wiley   +1 more source

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

PLoS ONE, 2010
BackgroundCytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)(2)D3, as well as 1-hydroxyvitamin D3 to 1alpha,20-dihydroxyvitamin D3 (1,20(OH)(2)D3). It also cleaves the side chain of 7-dehydrocholesterol producing 7-
Andrzej T Slominski, Zorica Janjetovic, Brian E Fuller, Michal A Zmijewski, Robert C Tuckey, Minh N Nguyen, Trevor Sweatman, Wei Li, Jordan Zjawiony, Duane Miller, Tai C Chen, Gerard Lozanski, Michael F Holick   +12 more
doaj   +1 more source

Development of a Chemiluminescence Immunoassay for Quantification of 25-Hydroxyvitamin D in Human Serum

Journal of Analytical Methods in Chemistry, 2020
In this study, a chemiluminescence immunoassay (CLIA) for human serum 25-hydroxyvitamin D (25(OH)D) was established by a competition model. In serum, more than 99% of total circulating 25(OH)D binds to protein and less than 1% of 25(OH)D is in free form (
Shuang Han, Wuxian Qiu, Junlan Zhang, Zhonghu Bai, Xiao Tong   +4 more
doaj   +1 more source