25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway [PDF]
International Journal of Oncology, 2019 Hyperlipidemia is associated with metastasis in patients with gastric cancer (GC). 25‑Hydroxycholesterol (25‑HC) is a type of oxysterol which is synthesized from cholesterol and is involved in a number of processes, including inflammation, immune responses and cancer development. However, the role of 25‑HC in gastric cancer remains unknown.
Wang, Saisai +4 more
openaire +4 more sources
Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol
Frontiers in Immunology, 2018 Persistent inflammation and extensive immune activation have been associated with HIV-1/SIV pathogenesis. Previously, we reported that cholesterol-25-hydroxylase (CH25H) and its metabolite 25-hydroxycholesterol (25-HC) had a broad antiviral activity in ...
Tongjin Wu +14 more
doaj +1 more source
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. [PDF]
PLoS ONE, 2017 N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptor mediating excitatory transmission throughout the CNS, participate in ischemia-induced neuronal death.
Min-Yu Sun +3 more
doaj +1 more source
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2021 Houttuynia cordata Thunb. (HC) is a traditional medicinal plant with a variety of pharmaceutical activities. The objective of this study was to investigate the growth, photosynthetic parameters, and antioxidant properties of HC plants in response to ...
Yu-Syuan LI +3 more
doaj +1 more source
Mechanisms of burst release from pH-responsive polymeric microparticles. [PDF]
, 2011 Microencapsulation of drugs into preformed polymers is commonly achieved through solvent evaporation techniques or spray drying. We compared these encapsulation methods in terms of controlled drug release properties of the prepared microparticles and ...
Donaldson, M +4 more
core +1 more source
Neuropsychiatric disturbances in atypical Parkinsonian disorders [PDF]
, 2018 Multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are the most common atypical parkinsonisms. These disorders are characterized by varying combinations of autonomic, cerebellar and pyramidal system ...
Belvisi, Daniele +6 more
core +1 more source
The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus
Viruses, 2019 Cholesterol, an essential component of mammalian cells, is also an important factor in the replicative-cycles of several human and animal viruses.
Ghada T. Shawli +3 more
doaj +1 more source
Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth. [PDF]
, 2013 Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates ...
Bensinger, Steven J, York, Autumn G
core +1 more source
Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism [PDF]
, 2020 Dysregulated cholesterol metabolism is implicated in a number of neurological disorders. Many sterols, including cholesterol and its precursors and metabolites, are biologically active and important for proper brain function. However, spatial cholesterol
Angelini, Roberto +10 more
core +2 more sources
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol
Journal of Lipid Research, 2015 Cholesterol homeostasis is regulated not only by cholesterol, but also by oxygenated cholesterol species, referred to as oxysterols. Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), regulate cholesterol homeostasis through feedback ...
David B. Iaea +10 more
doaj +1 more source