Results 1 to 10 of about 11,352 (188)

27-Hydroxycholesterol in cancer development and drug resistance [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
27-Hydroxycholesterol (27HC), a cholesterol metabolite, functions both as a selective oestrogen receptor (ER) modulator and a ligand for liver X receptors (LXRs).
Yaxin Hou, Zhiguang Fu, Chenhui Wang, Paulina Kucharzewska, Yuan Guo, Sihe Zhang   +5 more
doaj   +5 more sources

27-hydroxycholesterol and DNA damage repair: implication in prostate cancer. [PDF]

Front Oncol, 2023
IntroductionWe previously reported that cholesterol homeostasis in prostate cancer (PC) is regulated by 27-hydroxycholesterol (27HC) and that CYP27A1, the enzyme that converts cholesterol to 27HC, is frequently lost in PCs. We observed that restoring the CYP27A1/27HC axis inhibited PC growth.
Galvan GC, Friedrich NA, Das S, Daniels JP, Pollan S, Dambal S, Suzuki R, Sanders SE, You S, Tanaka H, Lee YJ, Yuan W, de Bono JS, Vasilevskaya I, Knudsen KE, Freeman MR, Freedland SJ.   +16 more
europepmc   +8 more sources

27-hydroxycholesterol linked high cholesterol diet to lung adenocarcinoma metastasis. [PDF]

Oncogene, 2022
AbstractDietary cholesterol has been implicated to promote lung cancer. Lung adenocarcinoma (LAC) is a main type of lung cancer, whereas the functional mechanism of cholesterol in LAC remained largely unknown. In the present study, we evidenced that cholesterol promoted cell proliferation and invasion of LAC in vitro as well as LAC metastasis in vivo ...
Li X, Chen H, Zhang L, Chen L, Wei W, Gao S, Xue Q, Li Y, Wang B, Li J, Gao Y, Lin Y.   +11 more
europepmc   +5 more sources

Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol.

Journal of Lipid Research, 1993
Sterol 27-hydroxylase, the mitochondrial enzyme that catalyzes the first step in oxidation of the sterol side chain in hepatic bile acid synthesis, also catalyzes the synthesis of 27-hydroxycholesterol from cholesterol.
B Petrack, B J Latario
doaj   +2 more sources

Paroxetine suppresses 27-hydroxycholesterol-induced responses in THP-1 human monocytic cells by regulating the AKT/mTORC1 pathway [PDF]

Scientific Reports
Paroxetine (PRX) is widely prescribed for treating psychiatric disorders. Emerging evidence suggests that PRX can act as an immunosuppressive agent, yet the molecular mechanisms underlying its effects are not fully understood. This study has investigated
Dongha Park, Yonghae Son, Dongjun Lee, Koanhoi Kim   +3 more
doaj   +2 more sources

Connecting the Dots Between Hypercholesterolemia and Alzheimer’s Disease: A Potential Mechanism Based on 27-Hydroxycholesterol [PDF]

Frontiers in Neuroscience, 2022
Alzheimer’s disease (AD), the most common cause of dementia, is a complex and multifactorial disease involving genetic and environmental factors, with hypercholesterolemia considered as one of the risk factors.
Mingan Wu, Mingan Wu, Yingying Zhai, Yingying Zhai, Xiaoyi Liang, Xiaoyi Liang, Weichun Chen, Weichun Chen, Ruiyi Lin, Ruiyi Lin, Linlin Ma, Linlin Ma, Yi Huang, Yi Huang, Di Zhao, Di Zhao, Yong Liang, Yong Liang, Wei Zhao, Wei Zhao, Jiansong Fang, Jiansong Fang, Shuhuan Fang, Shuhuan Fang, Yunbo Chen, Yunbo Chen, Qi Wang, Qi Wang, Weirong Li, Weirong Li   +29 more
doaj   +2 more sources

27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer. [PDF]

Cancers (Basel), 2022
Avena P, Casaburi I, Zavaglia L, Nocito MC, La Padula D, Rago V, Dong J, Thomas P, Mineo C, Sirianni R, Shaul PW.   +10 more
europepmc   +3 more sources

Retraction Note: 27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons. [PDF]

BMC Neurosci
Schommer J, Marwarha G, Schommer T, Flick T, Lund J, Ghribi O.   +5 more
europepmc   +3 more sources

Retraction: Gadd153 and NF-κB Crosstalk Regulates 27-Hydroxycholesterol-Induced Increase in BACE1 and β-Amyloid Production in Human Neuroblastoma SH-SY5Y Cells. [PDF]

PLoS One
PLOS ONE Editors.
europepmc   +3 more sources

27-Hydroxycholesterol induces expression of zonula occludens-1 in monocytic cells via multiple kinases pathways. [PDF]

Sci Rep, 2022
Cho HR, Kim BY, Kim K, Lee D, Eo SK, Son Y.   +5 more
europepmc   +3 more sources