Results 11 to 20 of about 11,352 (188)

27-Hydroxycholesterol: production rates in normal human subjects [PDF]

Journal of Lipid Research, 1999
We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj   +3 more sources

Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol. [PDF]

Front Cell Neurosci
Astrocytes represent the most abundant cell type in the brain, where they play critical roles in synaptic transmission, cognition, and behavior. Recent discoveries show astrocytes are involved in synaptic dysfunction during Alzheimer’s disease (AD). AD patients have imbalanced cholesterol metabolism, demonstrated by high levels of side-chain oxidized ...
Spanos F, Gerenu G, Goikolea J, Latorre-Leal M, Balleza-Tapia H, Gomez K, Álvarez-Jiménez L, Piras A, Gómez-Galán M, Fisahn A, Cedazo-Minguez A, Maioli S, Loera-Valencia R.   +12 more
europepmc   +6 more sources

The impact of 27-hydroxycholesterol on endometrial cancer proliferation [PDF]

Endocrine Abstracts, 2018
Endometrial cancer (EC) is the most common gynaecological malignancy. Obesity is a major risk factor for EC and is associated with elevated cholesterol. 27-hydroxycholesterol (27HC) is a cholesterol metabolite that functions as an endogenous agonist for Liver X receptor (LXR) and a selective oestrogen receptor modulator (SERM).
Douglas A Gibson, Frances Collins, Fiona L. Cousins, Arantza Esnal‐Zufiaurre, Philippa T. K. Saunders   +4 more
openalex   +4 more sources

Inhibitory Effects of Methanol Extract from Nardostachys chinensis on 27-hydroxycholesterol-induced Differentiation of Monocytic Cells

Biochemical and Biophysical Research Communications, 2017
27-Hydroxycholesterol (27OHChol) is a cholesterol oxidation product that induces inflammation. In the current study we investigated the effects of diclofenac on inflammatory responses caused by 27OHChol using human monocyte/macrophage (THP-1) cells. Transcription and secretion of CCL2, CCL3, and CCL4 chemokines enhanced by 27OHChol were significantly ...
Yonghae Son, Hyungwoo Kim, Beodeul Yang, Bo-Young Kim, Young Chul Park, Koanhoi Kim   +5 more
openalex   +3 more sources

Prednisolone suppresses the immunostimulatory effects of 27‑hydroxycholesterol

Experimental and Therapeutic Medicine, 2020
In cholesterol-fed rabbits, site-specific targeting of prednisolone nanoparticles results in significantly reduced neo-intimal inflammation with a decreased infiltration of monocytes/macrophages. To understand the molecular mechanisms underlying this, the current study investigated whether prednisolone affects the immune attributes of 27 ...
Bo Young Kim, Yonghae Son, Min Kim, Koanhoi Kim   +3 more
openalex   +4 more sources

Sex difference in flux of 27-hydroxycholesterol into the brain. [PDF]

Br J Pharmacol, 2021
Background and PurposeThe cerebrospinal fluid (CSF)/plasma albumin ratio (QAlb) is believed to reflect the integrity of the blood–brain barrier (BBB). Recently, we reported that QAlb is lower in females. This may be important for uptake of neurotoxic 27‐hydroxycholesterol (27OH) by the brain in particular because plasma levels of 27OH are higher in ...
Parrado-Fernandez C, Leoni V, Saeed A, Rodriguez-Rodriguez P, Sandebring-Matton A, Córdoba-Beldad CM, Bueno P, Gali CC, Panzenboeck U, Cedazo-Minguez A, Björkhem I.   +10 more
europepmc   +7 more sources

The role of 27-hydroxycholesterol in meta-inflammation. [PDF]

Korean J Physiol Pharmacol
27-Hydroxycholesterol (27OHChol), a prominent cholesterol metabolite present in the bloodstream and peripheral tissues, is a kind of immune oxysterol that elicits immune response. Recent research indicates the involvement of 27OHChol in metabolic inflammation (meta-inflammation) characterized by chronic responses associated with metabolic ...
Son Y, Choi E, Hwang Y, Kim K.
europepmc   +3 more sources

Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma [PDF]

Cells, 2020
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism. In the H295R cell line, a standard ACC in vitro model, mitotane was previously reported to enhance the production of some oxysterols.
Antonina Germano, Daniela Rossin, Valerio Leoni, Noemi Iaia, L. Saba, Vittoria Basile, Soraya Puglisi, Claudio Caccia, Giuseppe Poli, Fiorella Biasi, Massimo Terzolo   +10 more
openalex   +5 more sources

27-Hydroxycholesterol Negatively Affects the Function of Bone Marrow Endothelial Cells in the Bone Marrow. [PDF]

Int J Mol Sci
Woo SY, Shim WS, Lee H, Baryawno N, Song P, Kim BS, Yoon S, Oh SO, Lee D.   +8 more
europepmc   +3 more sources

Vitamin D, Folic Acid and Vitamin B₁₂ Can Reverse Vitamin D Deficiency-Induced Learning and Memory Impairment by Altering 27-Hydroxycholesterol and S-Adenosylmethionine. [PDF]

Nutrients, 2022
Wang L, Zhou C, Yu H, Hao L, Ju M, Feng W, Guo Z, Sun X, Fan Q, Xiao R.   +9 more
europepmc   +3 more sources