Results 21 to 30 of about 11,352 (188)

Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]

Cell Journal, 2023
Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi, Zahra Nazeri, Arash Rafeeinia, Seyedeh Pardis Pezeshki, Alireza Kheirollah, Yaghoob Farbood, Maryam Adelipour, Shirin Azizidoost, Maryam Cheraghzadeh   +8 more
doaj   +1 more source

RETRACTION: The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors-relevance to Parkinson's disease. [PDF]

J Neurochem
Marwarha, G., Rhen, T., Schommer, T., Ghribi, O.   +3 more
europepmc   +3 more sources

27-Hydroxycholesterol: the first identified endogenous SERM [PDF]

Trends in Endocrinology & Metabolism, 2011
The cholesterol metabolite 27-hydroxycholesterol (27OHC) classically delivers sterols from peripheral tissues to the liver and is a substrate for bile acid synthesis. Recent studies have revealed that 27OHC also binds to and modifies the function of estrogen receptors ERα and ERβ. Experiments in mice lacking the enzyme which synthesizes 27OHC, CYP27A1,
Michihisa, Umetani, Philip W, Shaul
openaire   +2 more sources

Obesity and Cancer: 27-Hydroxycholesterol, the Missing Link. [PDF]

Int J Mol Sci, 2020
Obesity is currently affecting more than 40% of the Americans, and if it progresses with this rate, soon one out of two Americans will be obese. Obesity is an important risk factor for several disorders including cardiovascular disease, the first cause of death in the United States.
Asghari A, Umetani M.
europepmc   +4 more sources

Our evolving understanding of how 27-hydroxycholesterol influences cancer. [PDF]

Biochem Pharmacol, 2022
Cholesterol has been implicated in the pathophysiology and progression of several cancers now, although the mechanisms by which it influences cancer biology are just emerging. Two likely contributing mechanisms are the ability for cholesterol to directly regulate signaling molecules within the membrane, and certain metabolites acting as signaling ...
Ma L, Cho W, Nelson ER.
europepmc   +3 more sources

The Plasma Distribution of Non-cholesterol Sterol Precursors and Products of Cholesterol Synthesis and Phytosterols Depend on HDL Concentration

Frontiers in Nutrition, 2022
Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols
Valéria Sutti Nunes, Eliton Juniro da Silva, Guilherme da Silva Ferreira, Sayonara Ivana Santos de Assis, Patrícia Miralda Cazita, Edna Regina Nakandakare, Vanessa Helena de Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintão   +8 more
doaj   +1 more source

27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator [PDF]

Maturitas, 2017
Estrogen receptors (ERs) mediate the actions of the steroidal estrogens, and are important for the regulation of several physiological and pathophysiological processes, including reproduction, bone physiology, cardiovascular physiology and breast cancer. The unique pharmacology of the ERs allows for certain ligands, such as tamoxifen, to elicit tissue-
Sisi, He, Erik R, Nelson
openaire   +2 more sources

SUN-016 27-Hydroxycholesterol a Selective Estrogen Receptor Modulator: Profiling 27-Hydroxycholesterol Effects on Estrogen Receptor Activity in Mice

Journal of the Endocrine Society, 2019
27-Hydroxycholesterol (27-HC) is the most prevalent metabolite of cholesterol in circulation, and also the first identified endogenous selective estrogen receptor (ER) modulator (SERM) (1). Previously, we found that 27-HC acts as an agonist of ER in breast cancer cells, while it acts as an antagonist of ER in endothelial cells in the cardiovasculature.
Arvand Asghari, Shiro Hiramitsu, Kevin Dao, Michihisa Umetani   +3 more
openalex   +2 more sources

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

Frontiers in Immunology, 2022
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis ...
Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon   +6 more
doaj   +1 more source

Are side-chain oxidized oxysterols regulators also in vivo?

Journal of Lipid Research, 2009
Oxsterols are oxygenated metabolites of cholesterol that are short-lived intermediates or end products in cholesterol excretion pathways. They are present in very low concentrations in mammalian systems, always accompanied by a high excess of cholesterol.
Ingemar Bjo¨rkhem
doaj   +1 more source