Results 31 to 40 of about 11,352 (188)

Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness [PDF]

Scientific Reports, 2019
AbstractCholesterol mediates its proliferative and metastatic effects via the metabolite 27-hydroxycholesterol (27-HC), at least in breast and endometrial cancer. We determined the serum lipoprotein profile, intratumoral cholesterol and 27-HC levels in a cohort of patients with well-differentiated papillary thyroid carcinoma (PTC; low/intermediate and ...
Giovanna Revilla, Monica de Pablo Pons, Lucía Baila-Rueda, Annabel García-León, David Santos, Ana Cenarro, Marcelo Magalhaes, R. M. Blanco, Antonio Moral, José Ignacio Pérez, Gerard Sabé, Cintia González, Victoria Fuste, Enrique Lerma, Manuel dos Santos Faria, Alberto de Leiva, Rosa Corcoy, Joan Carles Escolà-Gil, Eugenia Mato   +18 more
openaire   +4 more sources

Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers

Journal of Lipid Research, 2003
The side chain oxidized oxysterol 24S-hydroxycholesterol (24-OH-chol) is formed almost exclusively in the brain, and there is a continuous passage of this oxysterol through the circulation to the liver.
Valerio Leoni, Thomas Masterman, Pria Patel, Steve Meaney, Ulf Diczfalusy, Ingemar Björkhem   +5 more
doaj   +1 more source

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source

The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients

Redox Biology, 2020
There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on.
Alessandro Marcello, Andrea Civra, Rafaela Milan Bonotto, Lais Nascimento Alves, Sreejith Rajasekharan, Chiara Giacobone, Claudio Caccia, Roberta Cavalli, Marco Adami, Paolo Brambilla, David Lembo, Giuseppe Poli, Valerio Leoni   +12 more
doaj   +1 more source

Brain-Specific Oxysterols and Risk of Schizophrenia in Clinical High-Risk Subjects and Patients With Schizophrenia

Frontiers in Psychiatry, 2021
Accumulating evidence from clinical, genetic, and epidemiologic studies suggest that schizophrenia might be a neuronal development disorder. While oxysterols are important factors in neurodevelopment, it is unknown whether oxysterols might be involved in
Zuoli Sun, Lei Zhao, Qijing Bo, Zhen Mao, Yi He, Tao Jiang, Yuhong Li, Yuhong Li, Chuanyue Wang, Chuanyue Wang, Rena Li, Rena Li   +11 more
doaj   +1 more source

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology [PDF]

Science, 2013
Cholesterol and Cancer Obesity and high cholesterol levels are associated with an increased risk of breast cancer in post-menopausal women. Nelson et al. (p.
Erik R, Nelson, Suzanne E, Wardell, Jeff S, Jasper, Sunghee, Park, Sunil, Suchindran, Matthew K, Howe, Nicole J, Carver, Ruchita V, Pillai, Patrick M, Sullivan, Varun, Sondhi, Michihisa, Umetani, Joseph, Geradts, Donald P, McDonnell   +12 more
openaire   +2 more sources

[Retracted] The oncogenic roles of 27‑hydroxycholesterol in glioblastoma. [PDF]

Oncol Lett
Liu L, Li MY, Xing Y, Wang XY, Wang Y.
europepmc   +2 more sources

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain

Journal of Lipid Research, 2005
Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto the brain using plasma samples collected from the internal jugular ...
Maura Heverin, Steve Meaney, Dieter Lütjohann, Ulf Diczfalusy, John Wahren, Ingemar Björkhem   +5 more
doaj   +1 more source

Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes.

Journal of Lipid Research, 1993
The use of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for solubilizing cholesterol and 27-hydroxycholesterol has led to a study of their rates of 7 alpha-hydroxylation in microsomal preparations from hamster liver and HepG2 cells.
KO Martin, K Budai, NB Javitt
doaj   +1 more source

Oxysterols as Reliable Markers of Quality and Safety in Cholesterol Containing Food Ingredients and Products

Frontiers in Nutrition, 2022
Cholesterol is a lipid of high nutritional value that easily undergoes oxidation through enzymatic and non-enzymatic pathways, leading to a wide variety of cholesterol oxidation products (COPs), more commonly named oxysterols.
Federico Canzoneri, Valerio Leoni, Ginevra Rosso, Davide Risso, Roberto Menta, Giuseppe Poli   +5 more
doaj   +1 more source