Results 51 to 60 of about 25,706,191 (121)

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Phosphodiesterases, 3\u27,5\u27-cyclic nucleotide (PDEs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
3\u27,5\u27-Cyclic nucleotide phosphodiesterases (PDEs, 3\u27,5\u27-cyclic-nucleotide 5\u27-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3\u27,5\u27-cyclic nucleotide (usually cyclic AMP or cyclic GMP).
Yan, Chen
core   +1 more source

The YfiBNR signal transduction mechanism reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways [PDF]

, 2012
The genetic adaptation of pathogens in host tissue plays a key role in the establishment of chronic infections. While whole genome sequencing has opened up the analysis of genetic changes occurring during long-term infections, the identification and ...
Tina Jaeger (158216), Jenal Urs, Jacob G. Malone (158210), Blanka Andrea, Pablo Manfredi, Andrea Blanka, Guy R. Cornelis, Jacob G. Malone, Jaeger Tina, Cornelis Guy R., Bos, R., Manfredi, Pablo, Jacob G Malone, Dötsch, A., Jaeger, T., Blanka, A., Pablo Manfredi (158219), Cornelis, Guy R, Manfredi, P., Bos Raphael, Andrea Blanka (158227), Raphael Bos (158229), Jenal, Urs, Jaeger, Tina, Tina Jaeger, Malone, Jacob G., Urs Jenal (37942), Jenal, U., Blanka, Andrea, Malone Jacob G., Dötsch Andreas, Susanne Häussler (158235), Urs Jenal, Häussler, S., Andreas Dötsch, Cornelis, Guy R., Susanne Häussler, Häussler, Susanne, Manfredi Pablo, Häussler Susanne, Raphael Bos, Guy R. Cornelis (158232), Guy R Cornelis, Malone, Jacob G, Dötsch, Andreas, Cornelis, G. R., Andreas Dötsch (158223), Bos, Raphael, Malone, J. G.   +48 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Structural biology of bacterial response regulator proteins and their complexes with cognate ligands [PDF]

, 2009
Two bacterial response regulator systems were studied in this thesis. NMR spectroscopy and X-ray crystallography were used to determine the structures of both domains of the antibiotic sensor TipAL, as well as of the c-di-GMP receptor PA4608, in ...
Allan, Martin Georg
core   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Mechanisms of cyclic-di-GMP signaling : insight into the biochemistry, signal transduction and regulation of the bacterial second messenger cyclic-di-GMP [PDF]

, 2007
Bacteria are able to switch between two mutually exclusive lifestyles, motile single cells and sedentary multicellular communities that colonize surfaces.
Christen, Matthias
core   +1 more source

Molecular logics in dual sensor regulation of diguanylate cyclase activity—Phosphorylation OR blue‐light activation

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various sensory domains have been studied previously, how distinct inputs are ...
Maximilian Fuchs, Andreas Winkler
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Milos Jesenak, Francesca Levi‐Schaffer, Giuseppe Nocentini, Liam O'Mahony, Oscar Palomares, Frank Redegeld, Milena Sokolowska, Betty Van Esch, Marco Zurlo, Cristiana Stellato   +20 more
wiley   +1 more source

Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism [PDF]

, 1992
3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. Its prodrug, molsidomine (SIN-10), does not release NO but does modulate various cell functions.
Seifert, Roland, Jürgen Ervens, Roland Seifert, Ervens, J.   +3 more
core   +1 more source