Results 61 to 70 of about 25,706,191 (121)

Phosphodiesterases, 3\u27,5\u27-cyclic nucleotide (PDEs) in GtoPdb v.2025.1

3\u27,5\u27-Cyclic nucleotide phosphodiesterases (PDEs, 3\u27,5\u27-cyclic-nucleotide 5\u27-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3\u27,5\u27-cyclic nucleotide (usually cyclic AMP or cyclic GMP).
Yan, Chen
core   +1 more source

Probing the activity of diguanylate cyclases and c-di-GMP phosphodiesterases in real-time by CD spectroscopy.

, 2013
Bacteria react to adverse environmental stimuli by clustering into organized communities called biofilms. A remarkably sophisticated control system based on the dinucleotide 3′–5′ cyclic diguanylic acid (c-di-GMP) is involved in deciding whether to form ...
SICA, FILOMENA, Stelitano V, Cutruzzolà F., Giardina G, Franceschini S, PICA, ANDREA, Fernicola S, Brandt A, Rinaldo S   +8 more
core   +2 more sources

Chemiluminescent Biosensors for Detection of Second Messenger Cyclic di-GMP

, 2018
Bacteria colonize highly diverse and complex environments, from gastrointestinal tracts to soil and plant surfaces. This colonization process is controlled in part by the intracellular signal cyclic di-GMP, which regulates bacterial motility and biofilm ...
Dippel, Andrew B, Hammond, Ming C, Samuel Deutsch, Evans, Robert S, Deutsch, Samuel, Andrew B. Dippel (4911055), Ming C. Hammond (761236), Andrew B. Dippel, Anderson, Wyatt A, Wyatt A. Anderson (4911058), Robert S. Evans, Robert S. Evans (4911061), Ming C. Hammond, Wyatt A. Anderson, Samuel Deutsch (138809)   +14 more
core   +1 more source

Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli

, 2016
Intracellular levels of the bacterial second messenger c-di-GMP are controlled by antagonistic activities of diguanylate cyclases and phosphodiesterases. The phosphodiesterase PdeH was identified as a key regulator of motility in E. coli, while deletions
Ozaki, Shogo, Mazur, Adam, Schirmer, Tilman, Reinders, Alberto, Boehm, Alex, Jenal, Urs, Hee, Chee-Seng   +6 more
core   +1 more source

Cyclic GMP and cyclic AMP induced changes in control and hypertrophic cardiac myocyte function interact through cyclic GMP affected cyclic-AMP phosphodiesterases

, 1999
We tested the hypothesis that the negative functional effects of cyclic GMP (cGMP) would be greater after increasing cyclic AMP (cAMP), because of the action of cGMP-affected cAMP phosphodiesterases in cardiac myocytes and that this effect would be ...
Michaela Straznicka, Lin Yan, James Tse, Gary X Gong, Peter M Scholz, Harvey R Weiss   +5 more
core   +1 more source

Multiple Isozymes of Cyclic Nucleotide Phosphodiesterases in the Rat [PDF]

, 1990
Cyclic nucleotide phosphodiesterases catalyse the hydrolysis of 3'5'-cyclic nucleotides, such as cyclic AMP and cyclic GMP, to produce 5'-derivatives.
Lavan, Brian Edward
core   +1 more source

Identification of Signals Influencing Salmonella Typhimurium Sensory Cyclic-di-GMP Phosphodiesterases

Salmonella enterica serovar Typhimurium infects humans and animals via consumption of contaminated food or water. If Salmonella traverses the intestine and gets into the bloodstream, they can evade phagocytic killing within macrophages by adapting to ...
Ayers, Anna M.
core   +1 more source

Yc-1 Potentiates Nitric Oxide-Induced Relaxation in Guinea-Pig Trachea

, 2009
1 The effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1- benzylindazole) on tension, levels of cyclic GMP and cyclic AMP were investigated in guinea-pig trachea.
鄧哲明, Hwang, Tsong-Long; Wu, Chin-Chung; Teng, Che-Ming   +1 more
core  

Deletion of the c-di-GMP Phosphodiesterase BpdB Attenuates <i>Brucella melitensis</i> Virulence by Enhancing Oxidative Stress Sensitivity, Partially via the Host STING Signaling Pathway. [PDF]

Int J Mol Sci
Li N, Shi Q, Chen S, Feng Y, Li M, Li Y, Wang S, Bao Y, Qi J, Wu T, Tian M.   +10 more
europepmc   +1 more source

STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition. [PDF]

iScience
Bekere I, Hubarzhevska Y, Egender SV, Quoika PK, Öllinger R, Schrimpf MR, Rad R, Zacharias M, de Oliveira Mann CC.   +8 more
europepmc   +1 more source