Scan for Motifs: a webserver for the analysis of post-transcriptional regulatory elements in the 3' untranslated regions (3' UTRs) of mRNAs. [PDF]
Biswas A, Brown CM.
europepmc +1 more source
Comparative analysis of microRNAs in bovine colostrum and neonatal calf blood
Abstract BACKGROUND MicroRNAs (miRNAs) are short non‐coding RNAs that participate in a wide range of biological processes. MiRNAs are present in high concentrations in colostrum, and these may be potentially transferred to newborn calves being fed colostrum.
Do T Hue +7 more
wiley +1 more source
Modified ribosome profiling reveals high abundance of ribosome protected mRNA fragments derived from 3' untranslated regions. [PDF]
Miettinen TP, Björklund M.
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miR‐19a‐3p and miR‐19b‐3p Promote Microglia Activation Associated With Neuroinflammation
miR19a and miR19b enhance microglia activation. ABSTRACT Neuroinflammation, driven by microglia activation and the production of pro‐inflammatory cytokines, has been implicated in several neurological diseases and neuropathic pain. MicroRNAs (miRNAs) have emerged as important regulators of neuroinflammatory processes.
Faezeh Sahebdel +3 more
wiley +1 more source
Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3'-untranslated regions. [PDF]
Batagov AO, Kurochkin IV.
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RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li +3 more
wiley +1 more source
Cross‐Level Regulatory Interactions Underlying Human Immune Aging
We performed multi‐omics sequencing on peripheral blood samples from 69 individuals aged 23–75 years and identified multi‐layered molecular interaction networks underlying the process of immune senescence, which provides a comprehensive multi‐omics framework for understanding immune aging and identifying potential strategies to delay immunosenescence ...
Quanyou Wu +9 more
wiley +1 more source
Impaired pre-mRNA processing and altered architecture of 3' untranslated regions contribute to the development of human disorders. [PDF]
Michalova E, Vojtesek B, Hrstka R.
europepmc +1 more source
Abstract Mitochondria import the majority of their proteins from the cytosol, creating a fundamental challenge: precursor proteins must be synthesized, maintained in an import‐competent state, and delivered to mitochondrial translocases without premature folding or aggregation. While mitochondrial protein import has been considered a post‐translational
Nikita A. Kvasov, Yury S. Bykov
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Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus +5 more
wiley +1 more source

