Results 151 to 160 of about 5,521 (201)
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INCREASED BRAIN 3-HYDROXYKYNURENINE IN HUNTINGTON'S DISEASE
Lancet, The, 1989Gavin P Reynolds
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3-Hydroxykynurenine Toxicity on the Rat Striatum In Vivo
The Japanese Journal of Pharmacology, 1996 3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is elevated under several pathological states including Huntington's disease. In the present study, we examined the possible toxicity of 3-HK by injection of this substance into rat brain.
Hiroshi Katsuki, Yasuhiro Nakagami
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3-Hydroxykynurenine as a substrate/activator for mushroom tyrosinase
Archives of Biochemistry and Biophysics, 20033-Hydroxykynurenine is a tryptophan metabolite with an o-aminophenol structure. It is both a tyrosinase activator and a substrate, reducing the lag phase, stimulating the monophenolase activity, and being oxidized to xanthommatin. In the early stage of monophenol hydroxylation, catechol accumulation takes place, whereas 3-hydroxykynurenine is ...
Enrico Sanjust, Antonio Rescigno
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Oxidation of 3‐hydroxykynurenine. A reexamination
Journal of Heterocyclic Chemistry, 1988AbstractThe oxidation mixture of 3‐hydroxykynurenine (1), treated with aqueous acetic anhydride and, subsequently, with acidic methanol, yields the 1‐hydroxy‐3‐carbomethoxy‐5‐methoxy‐11‐(β‐aspartoyl‐N‐acetyl‐methyl ester)pyrido[3,2‐a]phenoxazine (5), the 1‐hydroxy‐11‐(β‐aspartoyl‐N‐acetyl‐methyl ester)‐5.H‐pyrido[3,2‐a]‐phenoxazin‐5‐one (6), the 1 ...
A. Bolognese +3 more
openaire +2 more sources
Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line
Brain Research, 1989 The toxicity of 3-hydroxykynurenine (3HK), an endogenous tryptophan metabolite which is markedly elevated in rat CNS tissue as a result of neonatal vitamin B-6 deficiency, was investigated in a neuronally derived hybrid cell line (N18-RE-105). At concentrations in excess of 100 microM, 3HK was toxic to greater than 85% of cultured cells over the course
Tomas R Guilarte
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