Results 151 to 160 of about 5,596 (203)
Some of the next articles are maybe not open access.
3-Hydroxykynurenine as a substrate/activator for mushroom tyrosinase
Archives of Biochemistry and Biophysics, 20033-Hydroxykynurenine is a tryptophan metabolite with an o-aminophenol structure. It is both a tyrosinase activator and a substrate, reducing the lag phase, stimulating the monophenolase activity, and being oxidized to xanthommatin. In the early stage of monophenol hydroxylation, catechol accumulation takes place, whereas 3-hydroxykynurenine is ...
Enrico Sanjust +2 more
exaly +3 more sources
Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease
Neuroscience Letters, 1992Concentrations of the neurotoxic tryptophan metabolite, 3-hydroxykynurenine, were determined in brain tissue taken post-mortem from patients with Huntington's disease and Alzheimer's disease. 3-Hydroxykynurenine was substantially and significantly increased in all three brain areas studied in Huntington's disease, but not significantly increased in the
S J Pearson, Gavin P Reynolds
exaly +3 more sources
3‐Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum
European Journal of Neuroscience, 1999Abstractl‐3‐Hydroxykynurenine (L‐3‐HK) and quinolinate (QUIN) are two metabolites of the kynurenine pathway, the major route of tryptophan degradation in mammals. L‐3‐HK is a known generator of highly reactive free radicals, whereas QUIN is an endogenous excitotoxin acting specifically at N‐methyl‐d‐aspartate (NMDA) receptors.
Paolo Guidetti, Robert Schwarcz
exaly +3 more sources
Oxidation of 3‐hydroxykynurenine. A reexamination
Journal of Heterocyclic Chemistry, 1988AbstractThe oxidation mixture of 3‐hydroxykynurenine (1), treated with aqueous acetic anhydride and, subsequently, with acidic methanol, yields the 1‐hydroxy‐3‐carbomethoxy‐5‐methoxy‐11‐(β‐aspartoyl‐N‐acetyl‐methyl ester)pyrido[3,2‐a]phenoxazine (5), the 1‐hydroxy‐11‐(β‐aspartoyl‐N‐acetyl‐methyl ester)‐5.H‐pyrido[3,2‐a]‐phenoxazin‐5‐one (6), the 1 ...
A. Bolognese +3 more
openaire +2 more sources
The Modification of Proteins by 3-Hydroxykynurenine
Experimental Eye Research, 1993The autoxidation and reactivity towards proteins of 3-hydroxykynurenine, a tryptophan metabolite found in the human lens, has been studied. At neutral pH, 3-hydroxykynurenine was readily oxidized using molecular oxygen with the formation of several coloured products.
G M, Stutchbury, R J, Truscott
openaire +2 more sources