Results 11 to 20 of about 3,733 (181)

Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke. [PDF]

PLoS ONE, 2013
3-Mercaptopyruvate sulfurtransferase (3MST) is an important enzyme for the synthesis of hydrogen sulfide (H2S) in the brain. We present here data that indicate an exclusively localization of 3MST in astrocytes. Regional distribution of 3MST activities is
Heng Zhao, Su-Jing Chan, Yee-Kong Ng, Peter T-H Wong   +3 more
doaj   +5 more sources

Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment via interacting with protein phosphatase 2A [PDF]

Acta Pharmaceutica Sinica B
The catalytic activity of 3-mercaptopyruvate (3MP) sulfurtransferase (MPST) converts 3MP to hydrogen sulfide (H2S). However, the regulatory mechanisms governing MPST and its impact on the brain remain largely unexplored.
Li Zhu, Yi Huang, Jing Jin, Rongjun Zou, Rui Zuo, Yong Luo, Ziqing Song, Linfeng Dai, Minyi Zhang, Qiuhe Chen, Yunting Wang, Wei Wang, Rongrong He, Yang Chen   +13 more
doaj   +2 more sources

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts [PDF]

Biomolecules, 2020
Down syndrome (trisomy of human chromosome 21) is a common genetic disorder. Overproduction of the gaseous mediator hydrogen sulfide (H2S) has been implicated in the pathogenesis of neurological and metabolic deficits associated with Down syndrome ...
Theodora Panagaki, Elisa B. Randi, Csaba Szabo   +2 more
doaj   +2 more sources

Hydrogen Sulfide From Cysteine Desulfurase, Not 3-Mercaptopyruvate Sulfurtransferase, Contributes to Sustaining Cell Growth and Bioenergetics in E. coli Under Anaerobic Conditions [PDF]

Frontiers in Microbiology, 2019
Endogenous hydrogen sulfide (H2S), which is primarily generated by 3-mercaptopyruvate sulfurtransferase (3-MST) in Escherichia coli (E. coli) under aerobic conditions, renders bacteria highly resistant to oxidative stress.
Jun Wang, Xin Guo, Heng Li, Haizhen Qi, Jing Qian, Shasha Yan, Junling Shi, Weining Niu   +7 more
doaj   +2 more sources

Role of the 3-mercaptopyruvate sulfurtransferase in colon/colorectal cancers

European Journal of Cell Biology
The 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase, occurring mainly in mitochondria. Although function of this protein in cancer cells has been already studied, no clear outcome can be postulated up to now.
Katarina Matyasova, Andrea Soltysova, Petr Babula, Olga Krizanova, Veronika Liskova   +4 more
doaj   +3 more sources

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells [PDF]

Biomolecules, 2020
3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant sources of biologically active sulfur species in various mammalian cells.
Fiona Augsburger, Elisa B. Randi, Mathieu Jendly, Kelly Ascencao, Nahzli Dilek, Csaba Szabo   +5 more
doaj   +2 more sources

H₂S, Polysulfides, and Enzymes: Physiological and Pathological Aspects [PDF]

Biomolecules, 2020
We have been studying the general aspects of the functions of H2S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years.
Noriyuki Nagahara, Maria Wróbel
doaj   +3 more sources

The expression of mercaptopyruvate sulfurtransferase serves as a potential biomarker for prognostic stratification and immunotherapy in certain cancers [PDF]

Frontiers in Oncology
Introduction3 - Mercaptopyruvate Sulfurtransferase (3 - MST) is an enzyme encoded by the Mercaptopyruvate Sulfurtransferase (MPST) gene. The enzyme is associated with a variety of cancers such as lung adenocarcinoma.
Boran Cui, Boran Cui, Chenchen Xia, Li Yang, Xiaoyu Xi, Xinxin Gong, Yixi Liu, Cai Tian, Xiaoli Du, Jiexian Du, Zengfang Hao   +10 more
doaj   +2 more sources

Effect of S-Allyl -L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis. [PDF]

Int J Mol Sci, 2020
The S-Allyl-L-cysteine (SAC) component of aged garlic extract (AGE) is proven to have anticancer, antihepatotoxic, neuroprotective and neurotrophic properties.
Bronowicka-Adamska P, Bentke A, Lasota M, Wróbel M.   +3 more
europepmc   +3 more sources

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells [PDF]

Frontiers in Pharmacology, 2017
Hypoxia-induced angiogenesis is a common phenomenon in many physiological and patho-physiological processes. However, the potential differential roles of three hydrogen sulfide producing systems cystathionine γ-lyase (CSE)/H2S, cystathionine β-synthase ...
Beibei Tao, Rui Wang, Chen Sun, Yichun Zhu   +3 more
doaj   +2 more sources