Results 21 to 30 of about 3,733 (181)

Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. [PDF]

Biochem Pharmacol, 2020
Hydrogen sulfide (H2S) is a physiological mediator that regulates cardiovascular homeostasis. Three major enzymes contribute to the generation of endogenously produced H2S, namely cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).
Peleli M, Bibli SI, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci M, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A.   +14 more
europepmc   +5 more sources

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. [PDF]

Br J Pharmacol, 2020
Background and PurposeDuring angiogenesis, quiescent endothelial cells (ECs) are activated by various stimuli to form new blood vessels from pre‐existing ones in physiological and pathological conditions. Many research groups have shown that hydrogen sulfide (H2S), the newest member of the gasotransmitter family, acts as a proangiogenic factor. To date,
Abdollahi Govar A, Törő G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos A, Módis K.   +11 more
europepmc   +6 more sources

Inhibition of the 3-mercaptopyruvate sulfurtransferase-hydrogen sulfide system promotes cellular lipid accumulation. [PDF]

Geroscience, 2022
Abstract H2S is generated in the adipose tissue by cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase (3-MST). H2S plays multiple roles in the regulation of various metabolic processes, including insulin resistance. H2S biosynthesis also occurs in adipocytes.
Casili G, Randi E, Panagaki T, Zuhra K, Petrosino M, Szabo C.   +5 more
europepmc   +3 more sources

Oxidative Stress and Iron Addiction: A Comparative Study of 1321N1 Astrocytoma and T98G Glioblastoma Cells with Differential Expression of L-Cysteine-Metabolizing Enzymes [PDF]

Biomolecules
Gliomas are central nervous system primary tumors that are distinguished by heterogeneity, broad-based infiltration, and metabolic reprogramming that sustains proliferation, invasion, and therapy refractoriness.
Halina Jurkowska, Ewa Jasek-Gajda, Konrad Kaleta, Leszek Rydz, Dominika Szlęzak, Maria Wróbel   +5 more
doaj   +2 more sources

The Effects of Genetic 3-Mercaptopyruvate Sulfurtransferase Deficiency in Murine Traumatic-Hemorrhagic Shock. [PDF]

Shock, 2019
ABSTRACT Introduction: Hemorrhagic shock is a major cause of death after trauma. An additional blunt chest trauma independently contributes to mortality upon the development of an acute lung injury (ALI) by aggravating pathophysiological consequences of hemorrhagic shock.
Gröger M, Wepler M, Wachter U, Merz T, McCook O, Kress S, Lukaschewski B, Hafner S, Huber-Lang M, Calzia E, Georgieff M, Nagahara N, Szabó C, Radermacher P, Hartmann C.   +14 more
europepmc   +4 more sources

Involvement of the Azotobacter vinelandii Rhodanese-Like Protein RhdA in the Glutathione Regeneration Pathway [PDF]

, 2012
The phenotypic features of the Azotobacter vinelandii RhdA mutant MV474 (in which the rhdA gene was deleted) indicated that defects in antioxidant systems in this organism were related to the expression of the tandem-domain rhodanese RhdA.
Forlani, Fabio, Guerrieri, Nicoletta, Klodmann, Jennifer, Pagani, Silvia, Papenbrock, Jutta, Remelli, William   +5 more
core   +8 more sources

Hydrogen sulfide pathway and skeletal muscle: an introductory review. [PDF]

, 2018
The presence of the H2 S pathway in skeletal muscle (SKM) has recently been established. SKM expresses the three constitutive H2 S-generating enzymes in animals and humans, and it actively produces H2 S.
Armogida Chiara, Bucci Mariarosaria, Vellecco Valentina   +2 more
core   +4 more sources

3‐Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinoma [PDF]

Liver International, 2022
Abstract Background and Aims The prognosis of hepatocellular carcinoma (HCC) remains dismal, and its molecular pathogenesis has not been completely defined.
Meng Li, Xin Song, Qi Jin, Yishu Chen, Jie Zhang, Jianguo Gao, Li Cen, Yiming Lin, Chengfu Xu, Xinjue He, Youming Li, Chaohui Yu   +11 more
openaire   +2 more sources

Sulfurtransferases and Cystathionine Beta-Synthase Expression in Different Human Leukemia Cell Lines

Biomolecules, 2022
The studies concerned the expression of sulfurtransferases and cystathionine beta-synthase in six human leukemia cell lines: B cell acute lymphoblastic leukemia-B-ALL (REH cells), T cell acute lymphoblastic leukemia-T-ALL (DND-41 and MOLT-4 cells), acute
Halina Jurkowska, Maria Wróbel, Ewa Jasek-Gajda, Leszek Rydz   +3 more
doaj   +1 more source

Arabidopsis thaliana 3-mercaptopyruvate sulfurtransferases interact with and are protected by reducing systems [PDF]

Journal of Biological Chemistry, 2021
The formation of a persulfide group (-SSH) on cysteine residues has gained attention as a reversible posttranslational modification contributing to protein regulation or protection. The widely distributed 3-mercaptopyruvate sulfurtransferases (MSTs) are implicated in the generation of persulfidated molecules and H2S biogenesis through transfer of a ...
Anna Moseler, Tiphaine Dhalleine, Nicolas Rouhier, Jérémy Couturier   +3 more
openaire   +3 more sources