Results 1 to 10 of about 5,827 (154)

AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs) [PDF]

Journal of Experimental & Clinical Cancer Research, 2019
Background The chemical carcinogen 3-methylcholanthrene (3MC) binds to the aryl hydrocarbon receptor (AHR) that regulates the expression of cytochrome P450 (CYP) enzymes as CYP1B1, which is involved in the oncogenic activation of environmental pollutants
Francesca Cirillo, Rosamaria Lappano, Leonardo Bruno, Bruno Rizzuti, Fedora Grande, Rita Guzzi, Sara Briguori, Anna Maria Miglietta, Miki Nakajima, Maria Teresa Di Martino, Marcello Maggiolini   +10 more
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Author Correction: Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation [PDF]

Scientific Reports, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Chih-Cheng Chang, Kuo-How Huang, Sung-Po Hsu, Yuan-Chii G. Lee, Yuh-Mou Sue, Shu-Hui Juan   +5 more
doaj   +2 more sources

Deciphering the molecular networks of 3-methylcholanthrene-induced clear cell renal cell carcinoma through multi-omics integration [PDF]

Scientific Reports
Exposure to 3-Methylcholanthrene (3-MC) may be associated with the development and progression of clear cell renal cell carcinoma (ccRCC); however, its underlying molecular mechanisms remain unclear.
Yuzhe Su, Peihuang Chen, Yaoan Wen, Jiangbin Yang, Yeda Chen, Shaoxing Zhu, Shuyuan Zhan, Song Zheng   +7 more
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Assessment of Homologous Recombination System Gene Expression in Chemologically Induced Carcinogenesis In Vivo Models [PDF]

Current Issues in Molecular Biology
Understanding the molecular mechanisms of carcinogenesis, including disruptions in the homologous recombination system, is fundamental to understanding malignant transformation.
Matvey M. Tsyganov, Danna Zh. Bulatova, Anastasia A. Fedorenko, Dmitry M. Loos, Pavel E. Nikiforov, Irina A. Tsydenova, Aigerim A. Bayanbayeva, Zhansaya Sharipkhanova, Sofia S. Timoshenko, Marina K. Ibragimova   +9 more
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Curability difference between autochthonous mouse tumors and their transplants in association with immune gene expression. [PDF]

PLoS ONE
Compared with transplanted tumors, autochthonous tumors are difficult to cure using experimental radiation therapy in mice. Here we analyzed differences in immune-related gene expression profiles between mouse fibrosarcomas subcutaneously induced by 3 ...
Hiroshi Tanooka, Chie Kudo-Saito, Fumiko Chiwaki, Masamichi Ishiai, Kouichi Tatsumi, Hiroki Sasaki, Takahiro Ochiya   +6 more
doaj   +2 more sources

3-Methylcholanthrene, an AhR agonist, caused cell-cycle arrest by histone deacetylation through a RhoA-dependent recruitment of HDAC1 and pRb2 to E2F1 complex. [PDF]

PLoS ONE, 2014
We previously showed that treating vascular endothelial cells with 3-methylcholanthrene (3MC) caused cell-cycle arrest in the Go/G1 phase; this resulted from the induction of p21 and p27 and a decreased level and activity of the cyclin-dependent kinase ...
Chih-Cheng Chang, Yuh-Mou Sue, Nian-Jie Yang, Yi-Hsuan Lee, Shu-Hui Juan   +4 more
doaj   +2 more sources

Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts [PDF]

Cancer Cell International, 2010
Background Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to elicit tumors in athymic mice.
Easton Marilyn J, Yoon Lawrence W, George Michael, Moore Tanya M, Crosby Lynn M, Ni Hong, Morgan Kevin T, DeAngelo Anthony B   +7 more
doaj   +2 more sources

Exploring the association between air pollutants and non-small cell lung cancer using network toxicology and machine learning [PDF]

Discover Oncology
Background Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide. The urgent need to understand its risk factors and develop effective treatment strategies drives ongoing research in this field.
Qiang Zhao, Zhiqiang Zhao, Kunpeng Du
doaj   +2 more sources

Inhibition activity of Artemisia vulgaris L. on Bhas 42 cell transformation [PDF]

Scientific Reports
Several factors can contribute to cancer development. Various methods are in use for cancer treatment, although their complications can be a cause of concern. Artemisia vulgaris L.
Paweena Pitimontol, Sumet Kongkiatpaiboon, Suwalee Worakhunpiset, Onrapak Reamtong, Nathamon Kosoltanapiwat, Kraichat Tantrakarnapa, Rachaneekorn Mingkhwan, Nuttapohn Kiangkoo, Yanin Limpanont   +8 more
doaj   +2 more sources

Multi-omics analysis and experiments validate the tumor-suppressive role of mitochondrial lipid metabolism gene ACSM5 in lung adenocarcinoma and its impact on the immune microenvironment [PDF]

Human Genomics
Background Lung adenocarcinoma (LUAD) is the most prevalent subtype of non-small cell lung cancer, characterized by high incidence and poor prognosis.
Sixuan Wu, Bowen Tang, Wujie Wei, Yuehua Li   +3 more
doaj   +2 more sources