Results 11 to 20 of about 5,846 (172)

Characterization of a novel cell line established from mice gastrointestinal stromal model by chemical induction [PDF]

Translational Oncology
Background: Gastrointestinal stromal tumors (GISTs) are a type of tumor that originates from gastrointestinal mesenchymal tissue. Although several somatic or germline mutation GIST mice were established, however, there is still a lack of an authentic ...
Zhan Zhao, Shenghui Qiu, Xiangwei Zhang, Shijin Liu, Lu Wang, Hanyang Guan, Jiashuai He, Yangzhi Hu, Xiaobo Li, Simin Luo, Zuyang Chen, Tianmu Mo, Yiran Zhang, Xiaoxu Zhao, Yunlong Pan, Hui Ding, Jie Cao, Jinghua Pan   +17 more
doaj   +2 more sources

Correction: Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts [PDF]

Cancer Cell International, 2010
Ni Hong, Easton Marilyn J, Yoon Lawrence W, Crosby Lynn M, Morgan Kevin T   +4 more
doaj   +2 more sources

Effects of cysteamine on 3-methylcholanthrene - induced fibrosarcoma in mice [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2013
Understanding the biology, developing methods for prevention and treatment of tumors is of great importance. The present study was investigated protective effects of the cysteamine on 3-methylcholantrene-induced fibrosarcoma in mice.
DOGAN A, AKSU P, ERDAG D, BAYEZIT M, DOGAN E, OZCAN K   +5 more
doaj   +1 more source

In Vitro Effects of Cabazitaxel and Menadione on Cell Growth, Metabolism, and Transcriptomic Profile of Human Prostate Cancer Cell Lines. [PDF]

Prostate Cancer
Cabazitaxel is a second‐generation semisynthetic taxane approved for the treatment of prostate cancer. Vitamin K, an essential nutrient involved in blood coagulation and bone metabolism, has also been shown to have antineoplastic effects. However, no information is currently available regarding the combinatorial effects of cabazitaxel and menadione ...
Gómez-Rosas AL, Chirinos M, Noyola-Martínez N, Segovia-Mendoza M, Torres-Ramírez N, Romero-Córdoba S, Noriega LG, García-Olivares M, Larrea F, Barrera D.   +9 more
europepmc   +2 more sources

Osteotoxicity of 3-methylcholanthrene in fish [PDF]

Ecotoxicology and Environmental Safety, 2018
Many chemicals produced by human activities end up in the aquatic ecosystem causing adverse developmental and reproductive effects in aquatic organisms. There is evidence that some anthropogenic chemicals disturb bone formation and skeletal development but the lack of suitable in vitro and in vivo systems for testing has hindered the identification of ...
Laizé Vincent, Gavaia Paulo, Tarasco Marco, Viegas Michael, Caria Joana, Luis Nuno, Cancela M. Leonor   +6 more
openaire   +2 more sources

Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms

Genes and Environment, 2023
Understanding of metabolic processes is a key factor to evaluate biological effects of carcinogen and mutagens. Applicability of fused-grid Template* systems of CYP enzymes (Drug Metab Pharmacokinet 2019, 2020, 2021, and 2022) was tested for three ...
Yasushi Yamazoe, Norie Murayama, Tomoko Kawamura, Takashi Yamada   +3 more
doaj   +1 more source

The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase. [PDF]

PLoS ONE, 2011
Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration of sarcoma cells on laminin-111.
Fabiana H M Melo, Diego Butera, Mara de Souza Junqueira, Daniel K Hsu, Ana Maria Moura da Silva, Fu-Tong Liu, Marinilice F Santos, Roger Chammas   +7 more
doaj   +1 more source

A method for measurement of nanogram quantities of 3-methylcholanthrene in stool samples.

Journal of Lipid Research, 1984
The carcinogen 3-methylcholanthrene can be produced from deoxycholic acid and is postulated by some investigators to play a role in the pathogenesis of colon carcinoma. The small quantities of this compound which could be carcinogenic have been difficult
W C Duane, J C Behrens, S G Kelly, A S Levine   +3 more
doaj   +1 more source

Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin

Toxicology Reports, 2023
Diazinon (DZN) is an insecticide extensively used to control pests in crops and animals. However, its indicriminated use may lead to liver damage in animals and humans. This study aimed to evaluate the toxicity of DZN (25–150 µM) on human hepatoblastoma (
Camila Araújo Miranda, Eduardo Morais Beretta, Layra Araújo Ferreira, Emmily Sousa da Silva, Beatriz Zimermano Coimbra, Priscila Tartari Pereira, Raul Ghiraldelli Miranda, Daniel Junqueira Dorta, Flávia Thomaz Verechia Rodrigues, Fábio Erminio Mingatto   +9 more
doaj   +1 more source

Expression of CYP2A3 mRNA and its regulation by 3-methylcholanthrene, pyrazole, and ß-ionone in rat tissues

Brazilian Journal of Medical and Biological Research, 2003
Cytochrome P450 (CYP) 2A enzymes are involved in the metabolism of numerous drugs and hormones and activate different carcinogens. Human CYP2A6, mouse CYP2A5 and rat CYP2A3 are orthologous enzymes that present high similarity in their amino acid sequence
A.B. Robottom-Ferreira, S.R. Aquino, R. Queiroga, R.M. Albano, L.F. Ribeiro Pinto   +4 more
doaj   +1 more source