Results 21 to 30 of about 5,846 (172)
Journal of Lipid Research, 1966 The lipids of mammary glands and mammary carcinomas from rats in various hormonal states were studied and compared with each other, with adipose tissue, and with a new transplantable sarcoma derived from cultured mammary carcinoma cells. When large doses
E. Douglas Rees +2 more
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The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function
Current Research in Toxicology, 2022 Polycyclic aromatic compounds (PACs) are a broad class of contaminants ubiquitously present in the environment due to natural and anthropogenic activities. With increasing industrialization and reliance on petroleum worldwide, PACs are increasingly being
Genevieve A Perono +3 more
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3-Methylcholanthrene uptake and metabolism in organ culture [PDF]
British Journal of Cancer, 1975 The uptake of 3-methycholanthrene and its metabolism to water-soluble derivatives were both determined in organ cultures of mouse and rat tissues, including prostate, skin, lung and skeletal muscle. All the tissues concentrated the carcinogen from the medium and metabolized part of it to water-soluble compounds.
Lasnitzki, I, Bard, D R, Franklin, H R
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Frontiers in Pharmacology, 2022 Acquired cisplatin resistance in cervical cancer therapy is principally caused by reduction in intracellular drug accumulation, which is exerted by hyperactivation of the oncogenic PI3K/Akt signaling axis and overexpression of cisplatin-exporter MRP2 ...
Elizabeth Mahapatra +6 more
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MODIFICATION OF REPRODUCTIVE FUNCTION IN THE RAT BY 3-METHYLCHOLANTHRENE
Pharmacological Research, 1997 Repeated exposure of adult female Wistar rats to 3-methylcholanthrene (MC) (25 mg kg(-1) b.w., i.p., 2xwk, 1 mo) was associated with a significant increase in estrus cycle length. In addition, an increased frequency of females with constant diestrus and abnormal cycles was observed.
Konstandi, M. +5 more
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Isopsoralen Enhanced Osteogenesis by Targeting AhR/ERĪ±
Molecules, 2018 Isopsoralen (IPRN), one of the main effective ingredients in Psoralea corylifolia Linn, has a variety of biological effects, including antiosteoporotic effects.
Luna Ge +3 more
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Monocrotophos induces the expression and activity of xenobiotic metabolizing enzymes in pre-sensitized cultured human brain cells. [PDF]
PLoS ONE, 2014 The expression and metabolic profile of cytochrome P450s (CYPs) is largely missing in human brain due to non-availability of brain tissue. We attempted to address the issue by using human brain neuronal (SH-SY5Y) and glial (U373-MG) cells. The expression
Vinay K Tripathi +11 more
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GFP transgenic medaka (Oryzias latipes) under the inducible cyp1a promoter provide a sensitive and convenient biological indicator for the presence of TCDD and other persistent organic chemicals. [PDF]
PLoS ONE, 2013 Persistent organic pollutants (POPs) are resistant to environmental degradation and can cause multitude of health problems. Cytochrome P450 1A (Cyp1a) is often up-regulated by POPs through the activation of aryl hydrocarbon receptor (AhR) pathway and is ...
Grace Hwee Boon Ng, Zhiyuan Gong
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Lipids in Health and Disease, 2019 Background A healthy gastric mucosal epithelium exhibits tumor-suppressive properties. Gastric epithelial cell dysfunction contributes to gastric cancer development.
Wenting Hong +7 more
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Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis. [PDF]
PLoS ONE, 2009 The Forkhead Box m1 (Foxm1) protein is induced in a majority of human non-small cell lung cancers and its expression is associated with poor prognosis.
I-Ching Wang +8 more
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