A Quantum Chemical Deep-Dive into the π-π Interactions of 3-Methylindole and Its Halogenated Derivatives—Towards an Improved Ligand Design and Tryptophan Stacking [PDF]
Pharmaceuticals, 2022 Non-covalent π-π stacking interactions often play a key role in the stability of the secondary and tertiary structures of peptides and proteins, respectively, and can be a means of ensuring the binding of ligands within protein and enzyme binding sites ...
Ruben Van Lommel +5 more
doaj +2 more sources
Effect of intranasal administration of Erigeron annuus and Carthamus tinctorius extracts in a rat model of olfactory dysfunction induced by 3-methylindole. [PDF]
PLoS ONEThere are many factors that can cause olfactory dysfunction, including upper respiratory tract viral infections, non-inflammatory respiratory diseases, trauma, and current treatments such as medications and surgery can have adverse effects and may not ...
Myeongguk Jeong +6 more
doaj +3 more sources
Screening, identification, and degradation characteristics of 3-methylindole degrading bacteria
Frontiers in Environmental Science, 2022 3-Methylindole is a major component of organic pollutants in livestock compost, which can contribute to the deterioration of the environment in livestock farms and their surrounding areas.
Feng Fei, Ma Huan
exaly +3 more sources
Isolation and characterization of two Acinetobacter species able to degrade 3-methylindole. [PDF]
PLoS ONE, 2019 3-Methylindole (3MI) or Skatole is a volatile lipophilic organic compound produced by anoxic metabolism of L-tryptophan and associated with animal farming and industrial processing wastes.
Tujuba Ayele Tesso +3 more
doaj +2 more sources
3-Methylindole is mutagenic and a possible pulmonary carcinogen. [PDF]
Toxicol Sci, 2009 Previous work has shown that bioactivation of the cigarette smoke pneumotoxicant 3-methylindole (3MI) by pulmonary cytochrome P450 enzymes is directly associated with formation of DNA adducts. Here, we present evidence that normal human lung epithelial cells, exposed to low micromolar concentrations of 3MI, showed extensive DNA damage, as measured by ...
Weems JM +7 more
europepmc +4 more sources
Removal of 3-methylindole by lactic acid bacteria in vitro. [PDF]
Exp Ther Med, 2013 3-Methylindole (3MI) is a substance with an unpleasant odor that is found in intact male pigs and is known to negatively affect consumers of pork. The growth of four strains of lactic acid bacteria [Lactobacillus brevis 1.12 (L. brevis 1.12), L. plantarum 102, L. casei 6103 and L. plantarum ATCC8014] in incubation medium with 3MI was studied.
Meng X, He ZF, Li HJ, Zhao X.
europepmc +4 more sources
Effects of Saccharomyces cerevisiae on the regulation of skatole, microorganisms, and tryptophan metabolites in vitro fermentation of pig [PDF]
Microbiology SpectrumSkatole (3-methylindole), one of the most malodorous compounds from swine manure, poses serious risks to animal, human, and environmental health. Therefore, it has become a serious concern in livestock farming.
Xiaoli Gao +4 more
doaj +2 more sources
Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes. [PDF]
PLoS ONE, 2016 Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking.
Martin Krøyer Rasmussen +4 more
doaj +2 more sources
Effects of Dietary Supplementation with Yeast Hydrolysate on Immune Function, Fecal Short Chain Fatty Acids, and Intestinal Health in Cats [PDF]
Veterinary SciencesYeast hydrolysate (YH) is rich in amino acids and other nutrients, and as a nutritional supplement it has been widely used in daily nutritional supplements for livestock.
Jintao Sun +8 more
doaj +2 more sources
Smelly communication between haemaphysalis longicornis and infected hosts with indolic odorants: A case from severe fever with thrombocytopenia syndrome virus. [PDF]
PLoS Neglected Tropical DiseasesObjectsVector ticks' perception of characteristic odors emitted by infected hosts is key to understand tick's foraging behavior for infected host and design odor-based control strategies for tick-borne diseases.MethodsLaboratory mice knocked out for type
Zhitong Liu +8 more
doaj +2 more sources