A Quantum Chemical Deep-Dive into the π-π Interactions of 3-Methylindole and Its Halogenated Derivatives—Towards an Improved Ligand Design and Tryptophan Stacking [PDF]
Pharmaceuticals, 2022 Non-covalent π-π stacking interactions often play a key role in the stability of the secondary and tertiary structures of peptides and proteins, respectively, and can be a means of ensuring the binding of ligands within protein and enzyme binding sites ...
Ruben Van Lommel +5 more
doaj +3 more sources
Isolation and characterization of two Acinetobacter species able to degrade 3-methylindole. [PDF]
PLoS ONE, 2019 3-Methylindole (3MI) or Skatole is a volatile lipophilic organic compound produced by anoxic metabolism of L-tryptophan and associated with animal farming and industrial processing wastes.
Tujuba Ayele Tesso +3 more
doaj +3 more sources
Effect of intranasal administration of Erigeron annuus and Carthamus tinctorius extracts in a rat model of olfactory dysfunction induced by 3-methylindole. [PDF]
PLoS ONEThere are many factors that can cause olfactory dysfunction, including upper respiratory tract viral infections, non-inflammatory respiratory diseases, trauma, and current treatments such as medications and surgery can have adverse effects and may not ...
Myeongguk Jeong +6 more
doaj +3 more sources
Screening, identification, and degradation characteristics of 3-methylindole degrading bacteria
Frontiers in Environmental Science, 2022 3-Methylindole is a major component of organic pollutants in livestock compost, which can contribute to the deterioration of the environment in livestock farms and their surrounding areas.
Lingyun Xiang
exaly +3 more sources
Transition Metal-Free Heteroarene Insertion Into C─C Bonds of Benzocyclobutenones. [PDF]
Angew Chem Int Ed EnglA transition metal‐free insertion of five‐membered heteroarenes into the C─C bonds of benzocyclobutenones has been achieved under mild and operationally simple conditions. This method provides an efficient and modular approach to access fused partially saturated hetero‐polycyclic scaffolds that exist in many bioactive molecules.
Wagner CJ, Dong G.
europepmc +3 more sources
Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies. [PDF]
Clin Transl MedTryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Wang R +5 more
europepmc +2 more sources
Effects of Saccharomyces cerevisiae on the regulation of skatole, microorganisms, and tryptophan metabolites in vitro fermentation of pig [PDF]
Microbiology SpectrumSkatole (3-methylindole), one of the most malodorous compounds from swine manure, poses serious risks to animal, human, and environmental health. Therefore, it has become a serious concern in livestock farming.
Xiaoli Gao +4 more
doaj +2 more sources
Gut microbiome-derived indoles differentially suppress type III secretion system-associated virulence in Escherichia coli and Salmonella enterica [PDF]
Frontiers in MicrobiologyEnteric pathogens such as enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC), and Salmonella enterica utilize a conserved type III secretion system (T3SS) to manipulate host cell processes and promote infection.
Michal Shvarthburg +4 more
doaj +2 more sources
Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes. [PDF]
PLoS ONE, 2016 Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking.
Martin Krøyer Rasmussen +4 more
doaj +2 more sources
Smelly communication between haemaphysalis longicornis and infected hosts with indolic odorants: A case from severe fever with thrombocytopenia syndrome virus. [PDF]
PLoS Neglected Tropical DiseasesObjectsVector ticks' perception of characteristic odors emitted by infected hosts is key to understand tick's foraging behavior for infected host and design odor-based control strategies for tick-borne diseases.MethodsLaboratory mice knocked out for type
Zhitong Liu +8 more
doaj +2 more sources