Results 61 to 70 of about 2,717 (170)

Discovery of N-arylsulfonyl-3-acylindole benzoyl hydrazone derivatives as anti-HIV-1 agents

Brazilian Journal of Pharmaceutical Sciences, 2019
The discovery and development of novel inhibitors with activity against variants of human immunodeficiency virus type 1 (HIV-1) is pivotal for overcoming treatment failure.
Zhiping Che, Yuee Tian, Shengming Liu, Mei Hu, Genqiang Chen   +4 more
doaj   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, Volume 13, Issue 29, 22 May 2026.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Regulation of Porcine Hepatic Cytochrome P450 — Implication for Boar Taint

Computational and Structural Biotechnology Journal, 2014
Cytochrome P450 (CYP450) is the major family of enzymes involved in the metabolism of several xenobiotic and endogenous compounds. Among substrates for CYP450 is the tryptophan metabolite skatole (3-methylindole), one of the major contributors to the off-
Martin Krøyer Rasmussen, Galia Zamaratskaia   +1 more
doaj   +1 more source

The Effect of Lactobacillus plantarum on the Fecal Microbiota, Short Chain Fatty Acids, Odorous Substances, and Blood Biochemical Indices of Cats

Microorganisms
Lactobacilli have played an important role in the gut health of pets. The aim of this research was to study the effects of isolated Lactobacilli (named L11) on the immune, nutrient metabolism, and gut health of cats.
Bing Han, Shukun Liang, Jintao Sun, Hui Tao, Zhenlong Wang, Baosheng Liu, Xiumin Wang, Jie Liu, Jinquan Wang   +8 more
doaj   +1 more source

GC-MS Characterization of Volatile Flavor Compounds in Stinky Tofu Brine by Optimization of Headspace Solid-Phase Microextraction Conditions

Molecules, 2018
This study optimized the headspace solid phase microextraction (HS-SPME) conditions for the analysis of the volatile flavor compounds of Chinese south stinky tofu brine by gas chromatography-mass spectrometry (GC-MS).
Hui Tang, Jin-Kui Ma, Lin Chen, Li-Wen Jiang, Jing Xie, Pao Li, Jing He   +6 more
doaj   +1 more source

A Novel Approach to 3-Methylindoles by a Heck/Cyclization/Isomerization Process

Organic Letters, 2010
A novel synthesis of 3-methylindoles from chlorotriflates through a Heck reaction, carbamate/aryl chloride coupling, and isomerization sequence is presented. The three-step sequence is highly efficient and general, enabling the regiocontrolled synthesis of substituted indoles in short order.
Baxter, C, Cleator, E, Alam, M, Davies, A, Goodyear, A, O'Hagan, M   +5 more
openaire   +3 more sources

Synthesis and Organocatalytic Activity of Imidazolidinone Organocatalysts

Molecules
A series of cis-5-arylmethyl-2-alkyl-3-methylimidazolidin-4-ones, prepared from arylmethyl-substituted α-amino acids, and a series of trans- and cis-2-(fluoromethyl)-2,3-dimethylimidazolidin-4-ones, derived from L-valine and L-leucine, were synthesized ...
Nejc Petek, Luka Ciber, Amalija Golobič, Andrej Mihevc, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj   +7 more
doaj   +1 more source

Phytochemical Profiling of Passiflora edulis Vines

Sciences of Phytochemistry
Over time Passiflora edulis f. flavicarpa (PEFF) have been utilized in traditional medicine for the treatment of different health ailments. This study aims to identify the phytochemical constituents in the vines of PEFF responsible for its traditional ...
Emmanuel Eimiomodebheki Odion, Godfavour Nzubechukwu Nwigwe, Daniel Akpe-Efiak Ambe, Monica Nnenna Nnamani, Chinyelu Clementina Osigwe, Loveth Uchechukwu Iyanyi, Eravweroso Congrat Odiete   +6 more
doaj   +1 more source

Gut microbiome-derived indoles differentially suppress type III secretion system-associated virulence in Escherichia coli and Salmonella enterica

Frontiers in Microbiology
Enteric pathogens such as enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC), and Salmonella enterica utilize a conserved type III secretion system (T3SS) to manipulate host cell processes and promote infection.
Michal Shvarthburg, David Taussig, Neta Even-Tov, Yariv Wine, Neta Sal-Man   +4 more
doaj   +1 more source

Lactiplantibacillus plantarum and quercetin synergistically ameliorate hyperuricemia through targeting multiple pathways

Food Science and Human Wellness
Hyperuricemia is a prevalent metabolic disorder resulting from dysregulation of purine metabolism, often accompanied by inflammation. It is characterized by an abnormal elevation in uric acid (UA) levels. In our investigation, the combined treatment with
Linyan Zhu, Mengyue Zhang, Juan Cheng, Yixuan Zhang   +3 more
doaj   +1 more source