Results 151 to 160 of about 13,314,497 (296)

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

1, 2, 3 - Triazoles as key frameworks in drug discovery & metal catalysis

, 2017
La tesis se enmarca dentro de la química de los 1H-1,2,3-triazoles y sus sales de N-alquil-triazolio. El trabajo realizado contempla los siguientes objetivos:1.- Sintetizar y estudiar los 1H-1,2,3-triazoles como plantillas moleculares de fármacos reguladores de [Ca2+] intraplasmático en músculo esquelético2.- Transformar triazoles 1,4-disustituidos en ...
openaire   +1 more source

Synthesis and Reactivity of 3‐Aminosydnones in Cycloaddition Reactions With Alkynes

Chemistry – A European Journal, EarlyView.
The synthesis, functionalization, and reactivity as dipoles of 3‐aminosydnones have been investigated. These neglected compounds undergo smooth cycloaddition reactions with strained alkynes, leading to 1‐aminopyrazoles. ABSTRACT We present in this article the synthesis, functionalization, and properties of 3‐aminosydnones, a forgotten class of ...
Apolline Dominic, Timothée D'anfray, Guillaume Force, David‐Alexandre Buisson, Maxime Tricoire, Alexis Leblais, Davide Audisio, Frédéric Taran   +7 more
wiley   +1 more source

H₃TPAN-Triazole-Bn-NH₂: Tripicolinate Clicked-Bifunctional Chelate for [²²⁵Ac]/[¹¹¹In] Theranostics

A new, high-denticity, bifunctional ligandH3TPAN-triazole-Bn-NH2has been synthesized and studied in complexation with [225Ac]­Ac3+ and [111In]­In3+ for radiopharmaceutical applications.
Valery Radchenko (754633), Hua Yang (120668), Luke Wharton (10203021), Maryam Osooly (12192140), François Bénard (1558723), Chengcheng Zhang (725743), Chris Orvig (1337916), Jutta Zeisler (2867582), Kuo-Shyan Lin (1558732), Cristina Rodríguez-Rodríguez (1951978), Paul Schaffer (2419417)   +10 more
core   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Synthesis and structure of novel 1,2,4-triazole derivatives containing the 2,4-dinitrophenylthio group

, 2009
Some novel 1,2,4-triazole derivatives containing the 2,4-dinitrophenylthio group have been synthesised in high yields by means of the reactions of 3-substituted-4-amino -1H-1,2,4-triazole-5(4H)-thiones or (E)-3-aryl-4-(benzylideneamino)-1H-1,2,4-triazole-
Du, HA, Ding, JY, Zhang, LX, Ding, QC, Zhang, LX, Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China., Lei, XX, Zhang, HL   +6 more
core  

Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker

Chemistry – A European Journal, EarlyView.
ABSTRACT In this study, we report the synthesis of an alkylene linker containing a terminal 2‐cyanoethyl protected selenium functionality for coupling at the 5'‐end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates.
Shivam Tikoo, Anne M. Noronha, Christopher J. Wilds   +2 more
wiley   +1 more source

Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle

Chemistry – A European Journal, EarlyView.
Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou, Jinbiao Jiao, Mathieu Lordez, Jean‐Yves Salpin, Juan Xie   +4 more
wiley   +1 more source

Boosting Zinc‐Ion Hybrid Capacitors with Mesoporous Carbon Derived from Highly Graphitized Carbon Quantum Dots

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The work presents an innovative method for the preparation of mesoporous carbon materials (MCs) from highly graphitized carbon quantum dots. The zinc‐ion hybrid capacitors assembled with MCs deliver high rate performance and stability, providing promising advancements for future energy storage solutions.
Guoli Zhang, Huihui Li, Kaiyue Wang, Gang Li, Kaixi Li, Taotao Guan, Kaiying Wang   +6 more
wiley   +1 more source

Toward Safer and Sustainable Lithium Metal Batteries: Fluorine‐Free Solid Polymer Electrolytes

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
An analysis to assess the impact of fluorine in polymer electrolyte‐based lithium metal batteries has been conducted. It has been demonstrated that fluorine‐free LiTIM salt delivers a electrochemical performance similar to that of its fluorinated analogue salts, given the complete lithium dissociation in coordination with PEO and the restricted anion ...
David Fraile‐Insagurbe, Leire Meabe, Brigette Althea Fortuin, Itsaso Segura‐Laparra, Elene Sasieta‐Barrutia, Rosalía Cid, Javier Carrasco, Władysław Wieczorek, Maria Forsyth, Michel Armand, María Martínez‐Ibañez   +10 more
wiley   +1 more source