Results 161 to 170 of about 47,847 (251)

Quinazolinone-triazole hybrids as multi-target-directed ligands for Alzheimer's disease: discovery of potent and selective MAO-B inhibitors with cholinesterase modulating activity. [PDF]

RSC Adv
Eldehna WM, El-Damasy AK, Lim J, Hefny SM, Al-Warhi T, Elgohary AS, El-Hamaky AA, Paik MJ, Elnagar MR, Elimam DM, Omar YM, Kim H, Tawfik HO.   +12 more
europepmc   +1 more source

Synthesis, antiproliferative and antibacterial activity of novel Phenothiazine-[1, 2, 3] triazole hybrids

Asian Journal of Pharmacy and Pharmacology, 2019
Sirassu Narsimha, Yellu Narasimha Reddy, Vasudeva Reddy Nagavelli   +2 more
openaire   +1 more source

Beyond monofunctionality: structural perspectives on phenol oxidase side activity in a catalase

Acta Crystallographica Section D, EarlyView.
Structural and biochemical characterization of the extracellular fungal catalase ClCPO uncovers an unexpected phenol oxidase promiscuity. Crystal structures, substrate docking and electron‐transfer pathway analysis identify ligand‐binding regions and support a working mechanistic model for catalase‐associated phenol oxidase activity.Catalases are ...
Christina Ferousi, Christos Kosinas, Odyssefs Ioannis Pantelakis, Efstratios Nikolaivits, Evangelos Topakas, Maria Dimarogona   +5 more
wiley   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Oxadiazolone-Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II-Induced Vascular Contraction. [PDF]

ChemMedChem
Ferreira LFL, Vasconcelos DGA, Santos RCA, Ferreira JG, Araújo AV, Anjos JVD.   +5 more
europepmc   +1 more source

Bruton tyrosine kinase inhibitors and cardiovascular adverse events

British Journal of Pharmacology, EarlyView.
Abstract Bruton tyrosine kinase inhibitors (BTKi) have transformed the management of chronic lymphocytic leukaemia and other B‐cell malignancies, yet their therapeutic benefit is tempered by clinically relevant cardiovascular toxicities (predominantly atrial fibrillation, hypertension, bleeding and ventricular arrhythmias).
Massimiliano Camilli, Cristina Madaudo, Emanuela Salvatorelli, Giorgio Minotti, Pierantonio Menna   +4 more
wiley   +1 more source

A Regioselective Approach to Accessing Trisubstituted Pyrrolo[2,3-d][1,2,3]triazoles via an Orthogonal Protection Strategy. [PDF]

Molecules
Brugemann K, Garnier S, Vercouillie J, Routier S, Buron F.   +4 more
europepmc   +1 more source

Exploring the Antitubercular, Antimicrobial Potency, ADME-T Calculations and Docking Studies of 1,2,4-Triazole-Bearing Benzimidazoles. [PDF]

Chem Biodivers
Shaik KM, Pandurangan K, Bhoomandla S, Mendam K, Ullapu PR.   +4 more
europepmc   +1 more source

Evolution of Dermatophytic Fungi: Anthropogenic and Biogenic Environmental Factors

International Journal of Dermatology, EarlyView.
ABSTRACT Climate change presents new challenges to dermatologic care, ranging from anthropogenic factors, such as pollution that select for extremotolerant and potentially antifungal‐resistant fungi, to biogenic factors that can drive zoonotic outbreaks, which have received increased attention since the SARS‐CoV‐2 pandemic.
Aditya K. Gupta, Tong Wang, Richard C. Summerbell   +2 more
wiley   +1 more source

Genetic diversity and antifungal susceptibility among ecological niche populations of Aspergillus flavus in Yaoundé, Cameroon. [PDF]

PLoS One
Kuate MPN, Ramkumar K, Dalmieda J, Nadeem J, Hemmati J, Nkenfou CN, Ndip RN, Xu J.   +7 more
europepmc   +1 more source