Results 141 to 150 of about 13,314,497 (296)
, 2018 Macrocyclic inhibitors of rhodesain (RD), a parasitic cysteine protease and drug target for the treatment of human African trypanosomiasis, have shown low metabolic stability at the macrocyclic ether bridge.
Saint-Auret, Sarah +32 more
core +1 more source
The Stabilization of High‐Nitrogen Systems: 10 Catenated Nitrogen Chain
Chemistry – A European Journal, EarlyView.Improving the understanding of high‐nitrogen materials. ABSTRACT High‐nitrogen materials have attracted intense interest in recent decades due to their unique chemical, physical, and biological properties. Stabilizing high‐nitrogen materials is often challenging as they become more unstable with increasing nitrogen catenation and nitrogen mass ...
Nicholas F. Scherschel +3 more
wiley +1 more source
Studies on 1, 2, 3-Triazole Derivatives. (2)
YAKUGAKU ZASSHI, 1957 Shun'ichi Yamada +2 more
openaire +2 more sources
3-Amino-1,2,4-triazole inhibits macrophage no synthase
, 1992 Murine macrophages activated by interferon-gamma and lipopolysaccharide become leishmanicidal through a process involving L-arginine-derived nitrogen oxidation products.
Pascal Schneider +9 more
core +1 more source
A Mononuclear Scenario for the Copper‐Catalyzed Monooxygenation of Phenolic Substrates
Chemistry – A European Journal, EarlyView.ABSTRACT Whereas a dinuclear pathway applies to the monooxygenation of phenols by the type 3 copper enzyme tyrosinase, a mononuclear pathway has been identified for the same reaction in corresponding small‐molecule systems. DFT calculations of five copper model complexes reveal that the latter mechanism is energetically feasible, identifying all ...
Alexander Koch +3 more
wiley +1 more source
Theoretical calculations of molecular descriptors for anticancer activities of 1, 2, 3-triazole-pyrimidine derivatives against gastric cancer cell line (MGC-803): DFT, QSAR and docking approaches. [PDF]
Heliyon, 2020 Oyewole RO, Oyebamiji AK, Semire B.
europepmc +1 more source
Synthetic CommunicationsA new series of 1,2,3-triazole skeleton incorporated pyrrole derivatives (11a–j) were developed and their chemical structures were confirmed by analytical data. Further, the anticancer profile of these newly derived compounds 11a–j was assessed against four types of human cancer cell lines such as human breast cancer (MCF-7), lung cancer (A549), colon ...
Nalla, Somaiah +5 more
openaire +1 more source
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Light‐Induced Anion Translocation to Control Helical Folding in an Artificial Communication System
Chemistry – A European Journal, EarlyView.Anion‐induced helical folding of an oligomer is controlled indirectly and reversibly by light through anion uptake/release by a photoresponsive receptor. Thus, a light signal is processed into a chemical signal in a communication‐type three‐component supramolecular system.
Indigo M. Bekaert +5 more
wiley +1 more source
A Low‐Symmetry FeII Tetrahedron From a Flexible Tritopic Ligand
Chemistry – A European Journal, EarlyView.A highly symmetric and flexible tris‐bidentate tritopic ligand forms an S4 meso homoleptic face‐capped FeII tetrahedron near‐quantitatively in acetonitrile. The addition of nitromethane solvent causes partial isomerization of this meso cage to the racemic homochiral tetrahedron, with the complexity of the system being moderated through solvophobic ...
Rosemary J. Goodwin +5 more
wiley +1 more source