Results 231 to 240 of about 13,314,497 (296)

Mutasynthesis and Antibiotic Activity of Mupirocin Analogues

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
A mutasynthetic strategy was developed to prepare pseudomonic acid analogues, and their antimicrobial activities were evaluated against five bacterial strains. Feeding studies with mutant strains of Pseudomonas fluorescens revealed that C7‐desepoxy‐PA‐B was metabolised to C7‐PA‐C with loss of the 8‐hydroxyl group, but no fatty acid chain extension ...
Sarah M. Husain, Luoyi Wang, Li‐Chen Han, James I. Bowen, Zhongshu Song, Felix de Courcy‐Ireland, Ashley J. Winter, Thomas J. Simpson, Paul R. Race, James Spencer, Matthew P. Crump, Christine L. Willis   +11 more
wiley   +1 more source

β-Mannosyl Triazoles as Mimics of Galactosyl Galectin-3 and Galectin-9 N-Terminal Domain Inhibitors. [PDF]

Chembiochem
Sjövall F, Nilsson UJ.
europepmc   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

Synthesis, Characterization, and Anticancer Activity of Vanadium (III) Complexes With Pyridyl-Triazole Ligands. [PDF]

Bioinorg Chem Appl
Alvarez-Ricardo Y, Jaramillo DN, Orjuela AL, Jiménez-Díaz E, Alí-Torres J, Macías MA, Arenaza-Corona A, Morales-Morales D, Hurtado JJ.   +8 more
europepmc   +1 more source

Toward Sustainable Carbonylation Reactions Enabled by CO Surrogates in Green Solvents

ChemSusChem, Volume 19, Issue 13, 14 July 2026.
Carbonylation reactions offer a sustainable route to valuable carbonyl compounds. This review highlights methodologies that exploit carbonylative coupling to drastically enhance process sustainability, avoiding the direct use of CO through CO surrogates and promoting syntheses in green solvents potentially derived from renewable and sustainable sources.
Francesco Messa, Serena Perrone, Antonio Salomone   +2 more
wiley   +1 more source

Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity. [PDF]

J Med Chem
Roshdy E, Kilic A, Mustafa M, Celik I, Sarı ZB, Simsek E, Nocentini A, Giovannuzzi S, Supuran CT, Özensoy Güler Ö, Winum JY, Abe M.   +11 more
europepmc   +1 more source

1, 2, 3-triazole as the Directing Group for Metal-Catalyzed C-H Activation

, 2019
openaire   +2 more sources

Combination Antifungal Therapy and Formulary Optimization for Progressive Invasive Pulmonary Aspergillosis in a Pediatric Patient With Acute Myeloid Leukemia: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Therapeutic response in refractory invasive pulmonary aspergillosis may depend not only on antifungal class escalation, but also on formulation choice. In this complex pediatric acute myeloid leukemia (AML) case, radiologic improvement followed combination therapy and switch to brand‐name liposomal amphotericin B, underscoring the importance ...
Faryal Khamis, Amal Al Busaidi, Kawther Al Bahrani, Asia Al‐Rashdi   +3 more
wiley   +1 more source

Rescuing TP53 from nonsense: novel triazoles for translational readthrough via optimized drug design. [PDF]

Sci Rep
Ricci D, Menditto M, Culletta G, Tutone M, Rizzo C, Pace A, Lentini L, Pibiri I.   +7 more
europepmc   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source