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Click Reactions in Kinetic Target-Guided Synthesis: Progress in the Discovery of Inhibitors for Biological Targets. [PDF]
Methods ProtocParvatkar PT, Satam N.
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SiO2 nanoparticles as platform for delivery of 3′-triazole analogues of AZT-triphosphate into cells
Bioorganic & Medicinal Chemistry, 2015A system for delivery of analogues of AZT-triphosphates (AZT*TP) based on SiO₂ nanoparticles was proposed. For this purpose, a simple and versatile method was developed for the preparation of SiO₂∼dNTP conjugates using the 'click'-reaction between AZTTP and premodified nanoparticles containing the alkyne groups.
Svetlana V. Vasilyeva +8 more
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Synthèse d'amino‐4 aryl‐3 triazol‐1,2,4 ones‐5
Journal of Heterocyclic Chemistry, 1979AbstractLa synthèse des arnino‐4 aryl‐3 triazol‐1,2,4 ones‐5 a été réalisée par quatre méthodes: a partir du carbohydrazide par reactions avec les chlorhydrates d'aryliminoéthers, l'orthobenzoate d'éthyle ou le trichlorophénylméthane, et aussi à partir du N‐carbéthoxyhydrazone du benzoate d'éthyle et de ses dérivés par réaction avec l'hydrazine.
René Milcent, Catherine Redeuilh
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1,2,
AbstractDevelopment of the non‐halogenated flame retardants (FRs) is an emerging research area as halogenated FRs are prone to produce carcinogenic and persistent organic pollutants. In this context, 1,2,3‐triazole synergized FR polymeric materials noticeably attained great interest in the last decade.
Kesavarao Sykam +2 more
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Journal of Fluorescence
This study aims to assess the potential bioactivity of newly designed benzodiazepine-1,2,3-triazole derivatives using in-silico methodologies, with a primary focus on elucidating their inhibitory interactions with the butyrylcholinesterase (BuChE) enzyme, which is implicated in Alzheimer's disease.
Yassine, El Allouche +7 more
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This study aims to assess the potential bioactivity of newly designed benzodiazepine-1,2,3-triazole derivatives using in-silico methodologies, with a primary focus on elucidating their inhibitory interactions with the butyrylcholinesterase (BuChE) enzyme, which is implicated in Alzheimer's disease.
Yassine, El Allouche +7 more
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Synthesis, In Vitro and In Silico Biological Studies of 1, 2, 3-Triazole-Furan Chalcone Hybrids
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2023In the present investigation, we focused our interest to develop 1, 2, 3-triazolefuran chalcone hybrids along with their biological profile. The synthesis of target molecules involves sequence of reactions, namely diazotization, nucleophilic substitution, cycloaddition and finally, solvent-free Claisen–Schmidt condensation reaction.
T. M. Somanatha +6 more
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Bioorganic & Medicinal Chemistry Letters
A library of 1, 2, 3-triazole incorporated thiazolylcarboxylate derivatives (7a-q) and (8a-j) were synthesized and evaluated for their in-vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The two compounds 7h and 8h have displayed excellent antitubercular activity with MIC values of 3.12 and 1.56 µg/mL respectively (MIC values of ...
Rajubai D. Bakale +8 more
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A library of 1, 2, 3-triazole incorporated thiazolylcarboxylate derivatives (7a-q) and (8a-j) were synthesized and evaluated for their in-vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The two compounds 7h and 8h have displayed excellent antitubercular activity with MIC values of 3.12 and 1.56 µg/mL respectively (MIC values of ...
Rajubai D. Bakale +8 more
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Wide-ranging Study on Synthesis and Biological Evaluation of 1, 2, 3-triazole
Current Bioactive CompoundsAbstract: 1, 2, 3-Traizole is five-membered heterocyclic compounds having three nitrogen at 1, 2 and 3 positions. 1, 2, 3-Triazoles are important five-membered heterocyclic scaffolds due to their widespread biological activities. 1, 2, 3-Triazole derivative can be readily obtained in good to excellent yields through click chemistry, 1, 3-dipolar ...
Anshu Dudhe +5 more
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Letters in Drug Design & Discovery, 2023
Background: The high mortality rate of cancer is endangering human health, and the research and development of new anticancer drugs have the attention of scientists worldwide. Sulfonamides have become the focus of anticancer drug research. 1,2,3-triazole compounds can inhibit the formation of a variety of tumor cells.
Qiu Lie Wei, Zhang Xing, Tong Jian Bo
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Background: The high mortality rate of cancer is endangering human health, and the research and development of new anticancer drugs have the attention of scientists worldwide. Sulfonamides have become the focus of anticancer drug research. 1,2,3-triazole compounds can inhibit the formation of a variety of tumor cells.
Qiu Lie Wei, Zhang Xing, Tong Jian Bo
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