Results 261 to 270 of about 13,314,497 (296)

Ring‐degenerate rearrangement of 5‐amino‐4‐iminomethyl‐1, 2, 3‐triazoles

Journal of Heterocyclic Chemistry, 1989
Abstract5‐Amino‐4‐(substituted)iminomethyl‐1‐phenyl‐1, 2, 3‐triazoles 5 rearrange thermally to 4‐amidino‐substituted triazoles 6 instead of undergoing the Dimroth rearrangement to 5‐anilinotriazoles 3.
Gerrit L'Abbé, Anna Vandendriessche
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Anti-proliferative effects of novel hybrids of 1, 2, 3-triazole-pyrimidines, 1, 2, 3–triazole–benzimidazoles and 1, 2, 3-triazole-coumarins

2015
The series of novel hybrids including: 1, 2, 3-triazole-pyrimidines, 1, 2, 3-triazole-coumarins and 1, 2, 3-triazole benzimidazoles were evaluated for their anti-proliferative activity against five human cancer cell lines and normal embryo mouse fibroblasts. Among these, TG-16 (C16H12ClN5 ; IC50=4, 83µM), TG-14 (C22H15BrF2N8O2 ; IC50=4, 53µM) and TG-15
Sedić, Mirela, Kraljević Pavelić, Sandra, Raić-Malić, Silvana, Tomljenović Paravić, Andrea   +3 more
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PHARMACOPHORE-BASED HYBRIDS OF NUCLEOSIDES AND 1, 2, 3-TRIAZOLES

2015
Nucleoside analogs have acquired an important role as therapeutic agents in the field of chemotherapy on account of their extensive biological activities. Introduction of a triazole ring into nucleosides to improve their bioactivity for antitumor or antiviral applications has become wide spread in drug design practices.1, 2 The 1, 2, 3-triazole unit ...
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Synthesis, anticancer evaluation, preliminary mechanism study of novel 1, 2, 3-triazole-piperlongumine derivatives

Molecular Diversity
Piperlongumine, a natural product from traditional Chinese medicine, shows promising antitumor effects but suffers from high toxicity. In this study, X and Q series Piperlongumine derivatives containing 1, 2, 3-triazole were designed and synthesized using the principle of molecular hybridization.
Nianlin, Feng, Xuemei, Qiu, Fulian, Li, Yue, Zhou, Chengpeng, Li, Bingqian, Liu, Jiao, Meng, Song, Bai, Zhurui, Li, Danping, Chen, Zhenchao, Wang   +10 more
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Synthesis and antiproliferative activity of the novel 1, 2, 3-triazole coumarin and quinoline derivatives

2018
1, 2, 3-triazole ring has a great role as pharmacophore which is responsible for antitumor and antimicrobial activity. It is introduced in many drugs due to moderate dipole properties, rigid structure and stability in vivo. Besides, 1, 2, 3-triazoles have attracted considerable attention in recent years because of their wide range of biological ...
Gazivoda Kraljević, Tatjana, Raić-Malić, Silvana, Sokol, Ivana   +2 more
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Design and synthesis of harmine and coumarin/quinoline hybrids bridged with 1, 2, 3-triazole

2019
Malaria, one of the neglected tropical diseases, is responsible for more than 430000 deaths and 210 million new cases annually. The cause of malaria, protozoal parasite of the genus Plasmodium, is developing resistance to the known drugs, which drives the need for the discovery and development of new antimalarials.
Perković, Ivana, Raić-Malić, Silvana, Rajić, Zrinka   +2 more
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Combination of 1,2,3-triazole and 1,2,4-triazole frameworks for new high-energy and low-sensitivity compounds

Energetic Materials Frontiers, 2021
Lei Qian, Hongwei Yang
exaly  

781. The tautomerism of 5-amino-1-aryl-1 : 2 : 3-triazoles

Journal of the Chemical Society (Resumed), 1953
B. R. Brown, D. Ll. Hammick, S. G. Heritage   +2 more
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Study on 1, 2, 3-Triazole-Containing Quinolines: Promising Pharmacological Hybrid Agents

2022
Leonor Y. Vargas-Méndez, Vladimir V. Kouznetsov   +1 more
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Synthesis of biologically interesting hybrids of nitrogen heterocycles and 1, 2, 3-triazole derivatives

2015
Cilj ovog rada bila je sinteza novih biološki aktivnih hibrida benzimidazola, pirimidina, 7- deazapurina i 1, 2, 3-triazola, kao odabranih dušikovih heterocikla. Regioselektivnom 1, 3- dipolarnom cikloadicijom azida i alkina uz katalizatore Cu(0), 1M CuSO4 uspješno su sintetizirani ciljani 1, 4-disupstituirani 1, 2, 3- triazolni derivati benzimidazola (
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