Results 71 to 80 of about 13,314,497 (296)

Estudo computacional de complexos mononucleares de cobre (II) e zinco (II) com ligantes triazólicos [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013.Neste trabalho foram estudados complexos mononucleares de cobre(II) ou zinco(II ...
Fonseca, David Edson Pedrosa
core  

1,3,4-Thiadiazole and 1,2,4-triazole-3(4 H )-thione bearing salicylate moiety: synthesis and evaluation as anti- Candida albicans

, 2017
Dramatically increased occurrence of both superficial and invasive fungal infections has been observed. Candida albicans appear to be the main etiological agent of invasive fungal infections. The anti-C.
Fares Kaed Alanazi (12847797), Awwad Abdoh Radwan (12847794), Mohammed Hamed Al-Agamy (12847800)   +2 more
core   +1 more source

Pyridine C─N Transposition via Cycloaddition–Cycloreversion

Angewandte Chemie, EarlyView.
Transposition of pyridine nitrogen from the 4‐ to the 3‐position is described using two open and shut sequences: a nucleophile addition ring‐open ring‐closure, followed by a nitrile Diels–Alder cycloaddition cycloreversion. The nitrogen swap is particularly effective for tertiary alkyl substituents, transforming easily accessible para‐alkylated ...
Aífe Conboy, Michael F. Greaney
wiley   +2 more sources

Design and Synthesis of Novel 3‑Nitro‑1H‑1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro Activity against Chagas Disease and Leishmaniasis

A series of 28 compounds, 3-nitro-1H-1,2,4-triazole, were synthesized by click-chemistry with diverse substitution patterns using medicinal chemistry approaches, such as bioisosterism, Craig-plot, and the Topliss set with excellent yields.
Carla C. P. Arruda (15367833), Gisele B. Portapilla (17895571), Cristiane Y. K. Shiguemoto (17895574), Fernanda Silva (4425223), Eliane M. Piranda (15367827), Diego B. Carvalho (15367806), Sergio de Albuquerque (14641304), M. Cristina Nonato (17895583), Kelly M. P. Oliveira (15367818), Norberto P. Lopes (420366), Jaqueline C. Z. Batista (17895568), Denise B. Silva (15367830), Bruno I. Pelizaro (17895565), Edgar J. Paredes-Gamero (491141), Lucas R. Pessatto (15367824), Amarith R. das Neves (17066794), Nadla S. Cassemiro (15367821), Iara A. Cardoso (17895577), Pedro H. Luccas (17895580), Fernanda Galvão (17895586), Adriano C. M. Baroni (2985447)   +20 more
core   +2 more sources

Synthesis, Cytostatic and Antibacterial Evaluations of N-4-benzoylcytosine–1, 2, 3-triazole and 7-deazapurine–1, 2, 3-triazole Hybrides

, 2017
Cytosine and 7-deazapurine (pyrrolo[2, 3-d]pyrimidine) derivatives have a great role in medicinal chemistry and have shown rather marked antitumor, antiviral, antibacterial and antiinflammatory activities.[1-4] 7-deazapurines are an important class of compounds, structurally and chemically related to naturally nucleosides.
Stipković Babić, Maja, Miošić, Mande, Mihovilović, Moris, Jukić, Marijana, Glavaš-Obrovac, Ljubica, Drenjančević, Domagoj, Raić-Malić, Silvana, Gazivoda Kraljević, Tatjana   +7 more
openaire   +2 more sources

Syntheses of Some 3,5-Diaryl-4H-1,2,4-triazole Derivatives and their Antifungal Activity

E-Journal of Chemistry, 2009
Syntheses of a series of 3, 5-diaryl-4H-1, 2, 4-triazole derivatives are described. In this present work, 4-amino-3-phenyl-5-p-tolyl-4H-1,2,4-triazole(1) was converted to N,N’-bis[3-phenyl-5-p-tolyl-4H-1,2,4-triazolyl]-1,4-xylenediimine(2) and 3-Phenyl-5-
Ram Janam Singh, Dharmendra Kumar Singh
doaj   +1 more source

Synthesis of novel 3-(2-bromophenyl)-4-substituted-1H-1,2,4-triazole-5(4H)-thiones derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
A wide range of biological activity of 1,2,4-triazole derivatives (anti-inflammatory, antiviral, antitumor, immunostimulating, etc.) and the availability of sources for their preparation determine the prospects of using compounds of this class to create ...
A. A. Safonov , A. V. Nevmyvaka
doaj   +1 more source

Synthesis of some New 1,2,4-Triazole derivatives [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2013
In the present work, compound 3-arylidene amino-5-methyl-1,2,4-triazole (IIIa-c), required as starting material obtained in one-pot reaction by condensing 5-methyl-3-amino-1,2,4-triazole with different aromatic aldehydes.
Ibtehal Kahtan Abdullah
doaj   +1 more source

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Nowadays an attempt to create a number of new biologically active compounds by many scientific groups is being one of the topical issues in the domestic pharmaceutical industry.
O. A. Bihdan, V. V. Parchenko
doaj   +1 more source