Cleavage of Stau2 by 3C protease promotes EV-A71 replication [PDF]
Virology JournalBackground Enterovirus A71 (EV-A71), as a neurotropic virus, mainly affects infants and young children under the age of 5. EV-A71 infection causes hand-foot-mouth disease and herpetic angina, and even life-threatening neurological complications. However,
Hui Li +5 more
doaj +4 more sources
Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in Picornaviruses. [PDF]
J Virol, 2022 Picornaviridae is a group of RNA viruses that harm both humans and livestock. 3C pro is an essential enzyme for picornavirus maturation, which makes it a promising target for antiviral drug development and a critical component for virus-like particle (VLP) production.
Meng K +5 more
europepmc +3 more sources
RIPK1 Is Cleaved by 3C Protease of Rhinovirus A and B Strains and Minor and Major Groups [PDF]
Viruses, 2021 Rhinoviruses (RV), like many other viruses, modulate programmed cell death to their own advantage. The viral protease, 3C has an integral role in the modulation, and we have shown that RVA-16 3C protease cleaves Receptor-interacting protein kinase-1 ...
Sarah N. Croft +2 more
doaj +2 more sources
Innate immune evasion mediated by picornaviral 3C protease: Possible lessons for coronaviral 3C-like protease? [PDF]
Rev Med Virol, 2021 SummarySevere acute respiratory syndrome coronavirus‐2 is the etiological agent of the ongoing pandemic of coronavirus disease‐2019, a multi‐organ disease that has triggered an unprecedented global health and economic crisis. The virally encoded 3C‐like protease (3CLpro), which is named after picornaviral 3C protease (3Cpro) due to their similarities ...
Ng CS, Stobart CC, Luo H.
europepmc +4 more sources
Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance [PDF]
VirusesEnterovirus-D68 (EV68) has emerged as a global health concern over the last decade with severe symptomatic infections resulting in long-lasting neurological deficits and death.
Vincent N. Azzolino +4 more
doaj +2 more sources
Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease [PDF]
VirusesEnterovirus-D68 (EV68) continues to present as a global health issue causing respiratory illness and outbreaks associated with long-lasting neurological disease, with no antivirals or specific treatment options. The development of antiviral therapeutics,
Vincent N. Azzolino +4 more
doaj +2 more sources
Natural Phytochemicals, Luteolin and Isoginkgetin, Inhibit 3C Protease and Infection of FMDV, In Silico and In Vitro [PDF]
Viruses, 2021 Foot-and-mouth-disease virus (FMDV) is a picornavirus that causes a highly contagious disease of cloven-hoofed animals resulting in economic losses worldwide. The 3C protease (3Cpro) is the main protease essential in the picornavirus life cycle, which is
Sirin Theerawatanasirikul +6 more
doaj +2 more sources
Development of FRET and Stress Granule Dual-Based System to Screen for Viral 3C Protease Inhibitors [PDF]
Molecules, 2023 3C proteases (3Cpros) of picornaviruses and 3C-like proteases (3CLpros) of coronaviruses and caliciviruses represent a group of structurally and functionally related viral proteases that play pleiotropic roles in supporting the viral life cycle and ...
Jingjing Zhang +6 more
doaj +2 more sources
3C protease of enterovirus 71 cleaves promyelocytic leukemia protein and impairs PML-NBs production [PDF]
Virology Journal, 2021 Background Enterovirus 71 (EV71) usually infects infants causing hand-foot-mouth disease (HFMD), even fatal neurological disease like aseptic meningitis. Effective drug for preventing and treating EV71 infection is unavailable currently. EV71 3C mediated
Zhuoran Li +5 more
doaj +2 more sources
Biochemical characterization of recombinant Avihepatovirus 3C protease and its localization [PDF]
Virology Journal, 2019 Background The picornaviral 3C protease mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription.
Di Sun +16 more
doaj +3 more sources