Structure-based virtual screening and molecular dynamics studies to explore potential natural inhibitors against 3C protease of foot-and-mouth disease virus [PDF]
Frontiers in Veterinary Science, 2023 Foot-and-mouth disease (FMD) is a highly infectious animal disease caused by foot-and-mouth disease virus (FMDV) and primarily infects cloven-hoofed animals such as cattle, sheep, goats, and pigs.
Sthitaprajna Sahoo +3 more
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Natural products repurposing of the H5N1-based lead compounds for the most fit inhibitors against 3C-like protease of SARS-CoV-2 [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2021 Context: COVID-19 pandemic has caused more than 2.7 million mortality worldwide. Although the COVID-19 vaccine has been developed, the amount is still limited, and very few countries have reached ‘herd immunity’ level.
Arli Aditya Parikesit, Rizky Nurdiansyah
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Human rhinovirus 3C protease: a cysteine protease showing the trypsin(ogen)‐like fold [PDF]
Biochemistry and Molecular Biology Education, 2001 AbstractViral‐encoded proteases cleave precursor polyprotein(s) leading to maturation of infectious virions. Strikingly, human rhinovirus 3C protease shows the trypsin(ogen)‐like serine protease fold based on two topologically equivalent six‐stranded β‐barrels, but displays residue Cys147 as the active site nucleophile.
BOLOGNESI M +2 more
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EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation.
PLoS ONE, 2019 Enterovirus 71 (EV71) induces apoptosis to promote viral particle release. Earlier work showed that EV71 utilizes its 3C protease to induce apoptosis in a caspase-3-dependent pathway, though the mechanism is unknown. However, work from Vagner, Holcik and
Mei-Ling Li +7 more
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Small Molecules Targeting 3C Protease Inhibit FMDV Replication and Exhibit Virucidal Effect in Cell-Based Assays [PDF]
Viruses, 2023 Foot-and-mouth disease (FMD) is a highly contagious disease in cloven-hoofed animals, caused by the foot-and-mouth disease virus (FMDV). It is endemic in Asia and Africa but spreads sporadically throughout the world, resulting in significant losses in ...
Sirin Theerawatanasirikul +5 more
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Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease [PDF]
FEBS Letters, 2015 Coxsackievirus B3 is the main cause of human viral myocarditis and cardiomyopathy. Virally encoded Coxsackievirus 3C protease (3Cpro) plays an essential role in viral proliferation. Here, benserazide was discovered as a novel inhibitor from a drug library screen targeting Coxsackievirus 3Cpro using a FRET‐based enzyme assay. Benserazide, whose chemical
Kim, Bo-Kyoung +7 more
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Degradation of Host Proteins and Apoptosis Induced by Foot-and-Mouth Disease Virus 3C Protease [PDF]
Pathogens, 2021 Foot-and-mouth disease (FMD), induced by the foot-and-mouth disease virus (FMDV), is a highly contagious disease of cloven-hoofed animals. Previous studies have reported that FMDV 3C protease could degrade multiple host proteins; however, the degradation
Jiamin Yi +7 more
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3C protease–independent production of foot-and-mouth disease virus-like particles in Pichia pastoris [PDF]
Applied Microbiology and BiotechnologyThe inactivated vaccines have played a pivotal role in the control and eradication of foot-and-mouth disease (FMD). However, certain safety concerns remain. Recently, virus-like particles (VLPs) have gradually become a research hotspot. As the eukaryotic
Zhiyao Li +7 more
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Limited impact of hepatitis A virus 3C protease-mediated cleavage on the functions of NEMO in human hepatocytes [PDF]
Journal of VirologyNF-κB essential modulator (NEMO) is critically involved in the induction of interferons (IFNs) and pro-inflammatory cytokines. Hepatitis A virus (HAV) 3C protease was recently identified to cleave NEMO in non-hepatic cells.
Hao-En Huang +3 more
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Synthesis and Initial Evaluation of a Novel Fluorophore for Selective FMDV 3C Protease Detection [PDF]
Molecules, 2020 The development and evaluation of a Boc-AL(Boc)Q(Trt)-AMC fluorophore to detect 3C Protease, produced by Foot and Mouth Disease Virus (FMDV) is reported, with a view to a potential use as a rapid screen for FMDV infected livestock The peptide-linked ...
Samerah Malik +3 more
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