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Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity. [PDF]

J Virol, 2022
Enteroviruses are significant human pathogens that cause viral myocarditis, pancreatitis, and meningitis. Knowing how the host controls these viruses and how the viruses may evade host restriction is important for understanding fundamental concepts in antiviral immunity and for informing potential therapeutic interventions.
Fan W, McDougal MB, Schoggins JW.
europepmc +3 more sources

Computational discovery of natural inhibitors targeting enterovirus D68 3C protease using molecular docking pharmacokinetics and dynamics simulations [PDF]

Scientific Reports
Enterovirus D68 (EV-D68) is a significant global health threat, responsible for severe respiratory and neurological complications, with no FDA-approved antiviral treatments currently available.
Mansoor Alsahag
doaj +2 more sources

Species-specific IL-1β is an inflammatory sensor of Seneca Valley Virus 3C Protease. [PDF]

PLoS Pathogens
Inflammasomes play pivotal roles in inflammation by processing and promoting the secretion of IL-1β. Caspase-1 is involved in the maturation of IL-1β and IL-18, while human caspase-4 specifically processes IL-18.
Xiangyu Huang +12 more
doaj +2 more sources

Severe acute respiratory syndrome coronavirus 3C-like protease-induced apoptosis [PDF]

FEMS Immunology & Medical Microbiology, 2006
The pathogenesis of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is an important issue for the treatment and prevention of severe acute respiratory syndrome. Recently, SARS-CoV has been demonstrated to induce cell apoptosis in Vero-E6 cells.
Cheng-Wen, Lin +4 more
openaire +3 more sources

Clonagem da Protease 3C do Deformed Wing Virus [PDF]