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Specific anion effect on properties of HRV 3C protease
Biophysical Chemistry, 2022Specific salts effect is intensively studied from the prospective of modification of different physico-chemical properties of biomacromolecules. Limited knowledge of the specific salts effect on enzymes led us to address the influence of five sodium anions: sulfate, phosphate, chloride, bromide, and perchlorate, on catalytic and conformational ...
Dušeková, Eva +9 more
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The Unusual Catalytic Triad of Poliovirus Protease 3C
Biochemistry, 2002Picornaviruses are small pathogen RNA viruses, like poliovirus, hepatitis A virus, rhinovirus, and others. They produce a large polyprotein, which is cleaved by virally encoded cysteine peptidases, picornains 2A and 3C. Picornain 3C represents an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain.
Zsuzsa, Sárkány, László, Polgár
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Purification, properties, and mutagenesis of poliovirus 3C protease
Virology, 1991Poliovirus protease 3C, type 1 Mahoney strain, was expressed in Escherichia coli under phage T7 promoter control and purified to homogeneity from resolubilized inclusion bodies. The renatured protein was as enzymatically active as the protease found in the soluble portion of the bacterial lysate.
E Z, Baum +4 more
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Development of anti-coxsackievirus agents targeting 3C protease
Bioorganic & Medicinal Chemistry Letters, 2012Peptidomimetic anti-viral agents against Coxsackievirus B3 (CVB3) were developed using a strategy involving the inhibition of 3C protease (CVB3 3C(pro)), a target for CVB3-mediated myocarditis or pericarditis. In an attempt to improve the inhibitory activity against CVB3, a variety of hetero-aromatic groups were incorporated into the α,β-unsaturated ...
Bo-Kyoung, Kim +7 more
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Development of potent inhibitors of the coxsackievirus 3C protease
Biochemical and Biophysical Research Communications, 2007Coxsackievirus B3 (CVB3) 3C protease (3CP) plays essential roles in the viral replication cycle, and therefore, provides an attractive therapeutic target for treatment of human diseases caused by CVB3 infection. CVB3 3CP and human rhinovirus (HRV) 3CP have a high degree of amino acid sequence similarity.
Eui Seung, Lee +12 more
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Enzymatic cleavage of fusion proteins using immobilised protease 3C
Protein Expression and Purification, 2006A strategy for efficient cleavage of fusion proteins using an immobilised protease has been developed. Protease 3C from coxsackie virus was recombinantly produced in Escherichia coli and covalently immobilised onto a solid support. Thereafter, Z(basic) tagged fusion proteins, with a specific cleavage sequence between the domains, were flown through the
Hedhammar, My +2 more
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Human rhinovirus 3C protease inhibitors: recent developments
Expert Opinion on Therapeutic Patents, 1998As members of the picornavirus family, human rhinoviruses (HRVs) are the major cause of the common cold in humans. In recent years, considerable efforts have been made in the development of anti-HRV compounds targeting rhinovirus enzymes including the viral proteases essential for viral replication. This article summarises the most recent approaches in
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The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease
Current Microbiology, 2020Enterovirus 71 (EV71) is the main pathogen of the hand, foot, and mouth disease. It was firstly isolated from sputum specimens of infants with central nervous system diseases in California in 1969, and has been repeatedly reported in various parts of the world, especially in the Asia-Pacific region. EV71 3C protein is a 183 amino acid cysteine protease
Weihui Wen, Zixuan Qi, Jing Wang
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Inhibition of human rhinovirus 3C protease by homophthalimides
Bioorganic & Medicinal Chemistry Letters, 1997Abstract Homophthalimides 2a and 3a were found to be inhibitors of Rhinovirus 3C protease through a blind screening effort. SAR studies resulted in compound 3g, which exhibited improved enzyme inhibition, in addition to whole cell antiviral activity.
Louis N. Jungheim +6 more
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[Current research on picornavirus 3C protease].
Bing du xue bao = Chinese journal of virology, 2015The picornavirus family comprises many small viruses, several of which are important pathogens of humans and livestock. The 3C protease (3Cpro) of different species and genera of picornavirus contains the classic G-X-C-G motif and Cys-His-Asp/Glu catalytic triad.
Hong, Wang +2 more
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